Top

Journal of Assisted Reproduction and Genetics

Published in:

01-09-2011 | ASSISTED REPRODUCTION TECHNOLOGIES

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Authors: Wei Wang, Xue-Hong Zhang, Wei-Hua Wang, Ya-Li Liu, Li-Hui Zhao, Shi-Long Xue, Ke-Hu Yang

Published in: Journal of Assisted Reproduction and Genetics | Issue 10/2011

Abstract

Objective

To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome.

Methods

We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration’s Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated.

Results

5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62–0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94–1.04), implantation rate (RR, 0.91; 95% CI, 0.40–2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58–1.08).

Conclusion

The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.

Griesinger G, Kolibianakis EM, Papanikolaou EG, Diedrich K, Van Steirteghem A, Devroey P, et al. Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. Fertil Steril. 2007;88:616–21.PubMedCrossRef

Gudmundsson J, Fleming R, Jamieson ME, McQueen D, Coutts JRT. Luteinization to oocyte retrieval delay in women in whom multiple follicular growth was induced as part of an in vitro fertilization/gamete intrafallopian transfer program. Fertil Steril. 1990;53:735–7.PubMed

Kuo TC, Endo K, Dharmarajan AM, Miyazaki T, Atlas SJ, Wallach EE. Direct effect of angiotensin II on in-vitro perfused rabbit ovary. J Reprod Fertil. 1991;92:469–74.PubMedCrossRef

Artini PG, Fasciani A, Monti M, Luisi S, D’Ambrogio G, Genazzani AR. Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization program. Fertil Steril. 1998;70:560–4.PubMedCrossRef

Bokal EV, Vrtovec HM, Virant Klun I, Verdenik I. Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome. Hum Reprod. 2005;20:1562–8.PubMedCrossRef

Artini PG, Monti M, Fasciani A, Battaglia C, D’Ambrogio G, Genazzani AR. Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol. 2002;101:169–74.PubMedCrossRef

World Health Organization. Temporal relationships between ovulation and defined changes in the concentration of plasma oE2–17β, luteinizing hormone, follicle stimulating hormone and progesterone. Am J Obstet Gynecol. 1980;138:383–90.

Nader S, Berkowitz AS. Study of the pharmacokinetics of human chorionic gonadotropin and its relation to ovulation. In Vitro Fert Embryo Transfer. 1990;7:114–8.CrossRef

Edwards RG, Steptoe PC. Induction of follicular growth, ovulation and luteinization in the human ovary. J Reprod Fertil. 1975;22(Suppl):121–63.

10.

Testart J, Frydman R. Minimum time lapse between luteinizing hormone surge or human chorionic gonadotropin administration and follicular rupture. Fertil Steril. 1982;37:50–3.PubMed

11.

Trounson AO, Leeton JF, Wood C. In vitro fertilization and embryo transfer in the human. In: Rolland R, van Hall EV, Hillier SG, Mcnatty KP, Schoemaker J, editors. Follicular maturation and ovulation. Amsterdam, Exerpta Medica 1982:313

12.

De Vits A, Gerris J, Joostens M, Aytos A. Comparison between two hCG-to-oocyte aspiration intervals (36 versus 38) on the outcome of in-vitro fertilization. Hum Reprod. 1994;9(Suppl):12–5.

13.

Mansour RT, Aboulghar MA, Serour GI. Study of the optimum time for human chorionic gonadotropin-ovum pickup interval in in vitro fertilization. J Assist Reprod Genet. 1994;11:478–81.PubMedCrossRef

14.

Fleming R, Coutts JRT. Induction of multiple follicular development for IVF. Brit Med Bull. 1990;46:596–615.PubMed

15.

Al-Mizyen ES, Balet R, Lower AM, Wilson C, McClure AF, Al Shawaf T, et al. Unexpected successful fertilization in vitro of oocytes retrieved 60 hours after human chorionic gonadotrophin injection. Hum Reprod. 1998;13:1020–1.PubMedCrossRef

16.

Nargund G, Reid F, Parsons J. Human chorionic gonadotropin-to-oocyte collection interval in a superovulation IVF program. A prospective study. J Assist Reprod Genet. 2001;18:87–90.PubMedCrossRef

17.

Bjercke S, Tanbo T, Dale PO, Abyholm T. Comparison between two hCG-to-oocyte aspiration intervals on the outcome of in vitro fertilization. J Assist Reprod Genet. 2000;17:319–22.PubMedCrossRef

18.

Higgins J, Green S, editors. Cochrane handbook for systematic reviews of interventions 5.0.0 [updated February 2008]. In: The Cochrane collaboration. Wiley 2008.

19.

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.PubMedCrossRef

20.

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.PubMedCrossRef

21.

Claman P, Wilkie V, Collins D. A short (335 h) compared with a long (395 h) interval between HCG injection and intrauterine insemination after superovulation therapy. Hum Reprod. 2000;15:6–7.

22.

Claman P, Wilkie V, Collins D. Timing intrauterine insemination either 33 or 39 hours after administration of human chorionic gonadotropin yields the same pregnancy rates as after superovulation therapy. Fertil Steril. 2004;82:13–6.PubMedCrossRef

23.

Fischer RA, Nakajima ST, Gibson M, Brumsted JR. Ovulation after intravenous and intramuscular human chorionic gonadotropin. Fertil Steril. 1993;60:418–22.PubMed

24.

Howles CM, Macnamee MC, Edwards RG. Progesterone supplementation in the late follicular phase of an in-vitro fertilization cycle: a ‘natural’ way to time oocyte recovery? Hum Reprod. 1988;3:409–12.PubMed

25.

Laufer N, DeCherney AH, Tarlatzis BC, Zuckerman AL, Polan ML, Dlugi AM, et al. Delaying human chorionic gonadotropin administration in human menopausal gonadotropin-induced cycles decreases successful in vitro fertilization of human oocytes. Fertil Steril. 1984;42:198–203.PubMed

26.

Templeton AA, Van Look P, Angell RE, et al. Oocyte recovery and fertilization rates in women at various times after the administration of hCG. J Reprod Fertil. 1986;76:771–8.PubMedCrossRef

27.

Schachter M, Friedler S, Ron-El R, Zimmerman AL, Strassburger D, Bern O, et al. Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study. Fertil Steril. 2008;90:1087–93.PubMedCrossRef

28.

Raziel A, Schachter M, Strassburger D, Kasterstein E, Ron-El R, Friedler S. In vivo maturation of oocytes by extending the interval between human chorionic gonadotropin administration and oocyte retrieval. Fertil Steril. 2006;86:583–7.PubMedCrossRef

29.

Jamieson ME, Fleming R, Kader S, Ross KS, Yates RW, Coutts JR. In vivo and in vitro maturation of human oocytes: effects on embryo development and polyspermic fertilization. Fertil Steril. 1991;56:93–7.PubMed

30.

Schmidt DW, Maier DB, Nulsen JC, Benadiva CA. Reducing the dose of human chorionic gonadotropin in high responders does not affect the outcomes of in vitro fertilization. Fertil Steril. 2004;82:841–6.PubMedCrossRef

31.

Isik AZ, Vicdan K. Combined approach as an effective method in the prevention of severe ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol. 2001;97:208–12.PubMedCrossRef

32.

Jagiello G, Karniki J, Ryan R. Superovulaton with pituitary gonadotropin methods for obtaining meiotic metaphase figures in human ova. Lancet. 1968;1:178–80.CrossRef

33.

Van Steirteghem AC, Liu J, Joris H, Nagy Z, Janssenswillen C, Tournaye H, et al. Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum Reprod. 1993;8:1055–60.PubMed

34.

Steptoe PC, Edwards RG. Laparoscopic recovery of preovulatory human oocytes after priming of ovaries with gonadotrophins. Lancet. 1970;1:683–9.PubMedCrossRef

35.

Edwards RG, Steptoe PC. Control of human ovulation, fertilization and implantation. Proc R Soc Med. 1974;67:932–6.PubMed

36.

Andersen AG, Als-Nielsen B, Hornnes PJ, Franch Andersen L. Time interval from human chorionic gonadotrophin (HCG) injection to follicular rupture. Hum Reprod. 1995;10:3202–5.PubMed

37.

Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril. 1994;62:353–62.PubMed

38.

Son WY, Chung JT, Chian RC, Herrero B, Demirtas E, Elizur S, et al. A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles. Hum Reprod. 2008;23:2010–6.PubMedCrossRef

39.

Hull MG, Fleming CF, Hughes AO, McDermott A. The age-related decline in female fecundity: a quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization. Fertil Steril. 1996;65:783–90.PubMed

40.

Schnorr JA, Doviak MJ, Muasher SJ, Jones Jr HW. Impact of a cryopreservation program on the multiple pregnancy rate associated with assisted reproductive technologies. Fertil Steril. 2001;75:147–51.PubMedCrossRef

41.

Thurin A, Hausken J, Hillensjo T, Jablonowska B, Pinborg A, Strandell A, et al. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med. 2004;351:2392–402.PubMedCrossRef

42.

Lukassen HGM, Braat DD, Wetzels AMM, Zielhuis GA, Adang EMM, Scheenjes E, et al. Two cycles with single embryo transfer versus one cycle with double embryo transfer: a randomized controlled trial. Hum Reprod. 2005;20:702–8.PubMedCrossRef

43.

Veleva Z, Vilska S, Hyden-Granskog C, Tiitinen A, Tapanainen JS, Martikainen H. Elective single embryo transfer in women aged 36–39 years. Hum Reprod. 2006;21:2098–102.PubMedCrossRef

44.

Van Royen E, Mangelschots K, De Neubourg D, Valkenburg M, Van de Meerssche M, Ryckaert G, et al. Characterization of a top quality embryo, a step towards single-embryo transfer. Hum Reprod. 1999;14:2345–9.PubMedCrossRef

45.

Roux C, Joanne C, Agnani G, Fromm M, Clavequin MC, Bresson JL. Morphometric parameters of living human in-vitro fertilization embryos; importance of the asynchronous division process. Hum Reprod. 1995;10:1201–7.PubMed

46.

Hiiragi T, Solter D. Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0? Cell Cycle. 2005;4:661–4.PubMedCrossRef

47.

Gardner RL, Davies TJ. An investigation of the origin and significance of bilateral symmetry of the pronuclear zygote in the mouse. Hum Reprod. 2006;21:492–502.PubMedCrossRef

48.

Racowsky C, Jackson KV, Cekleniak NA, Fox JH, Hornstein MD, Ginsburg ES. The number of eight-cell embryos is a key determinant for selecting day 3 or day 5 transfer. Fertil Steril. 2000;73:558–64.PubMedCrossRef

49.

Scott L, Finn A, O’Leary T, McLellan S, Hill J. Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates. Hum Reprod. 2007;22:230–40.PubMedCrossRef

Title: The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis
Authors: Wei Wang
Xue-Hong Zhang
Wei-Hua Wang
Ya-Li Liu
Li-Hui Zhao
Shi-Long Xue
Ke-Hu Yang
Publication date: 01-09-2011
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 10/2011
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9613-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 10/2011

Identification of common mechanisms between endometriosis and ovarian cancer

Prognostic value of triploid zygotes on intracytoplasmic sperm injection outcomes

Proliferative potential and phenotypic analysis of long-term cultivated human granulosa cells initiated by addition of follicular fluid

Altitude can alter the mtDNA copy number and nDNA integrity in sperm

Detection of aneuploidy rate for chromosomes X, Y and 8 by fluorescence in-situ hybridization in spermatozoa from patients with severe non-obstructive oligozoospermia

Association study of HLA-B alleles with idiopathic male infertility in Han population of China