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Journal of Assisted Reproduction and Genetics

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01-09-2007 | Immunology Updates

What is the role of regulatory T cells in the success of implantation and early pregnancy?

Authors: Shigeru Saito, Tomoko Shima, Akitoshi Nakashima, Arihiro Shiozaki, Mika Ito, Yasushi Sasaki

Published in: Journal of Assisted Reproduction and Genetics | Issue 9/2007

Abstract

Problem

The immune system is well controlled by the balance between immunostimulation and immunoregulation. CD4⁺CD25⁺ regulatory T (Treg) cells and an enzyme called indoleamine-2, 3-dioxygenase (IDO) mediate maternal tolerance of the allogeneic fetus. Treg cells, therefore, may prevent early pregnancy loss due to maternal ‘rejection.’

Methods

The latest understanding of tolerance during pregnancy is reviewed.

Results and conclusions

Recent data show that CD4⁺CD25⁺ Treg cells play essential roles in the induction and maintenance of tolerance, and that they augment the IDO activity in dendritic cells and macrophages. Therefore, CD4⁺CD25⁺ Treg cells and IDO enzyme may cooperate in the induction of tolerance during pregnancy. Treg deficiency is associated with very early post-implantation loss and spontaneous abortion in animal models, and low Treg levels are associated with recurrent miscarriages in humans.

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Title: What is the role of regulatory T cells in the success of implantation and early pregnancy?
Authors: Shigeru Saito
Tomoko Shima
Akitoshi Nakashima
Arihiro Shiozaki
Mika Ito
Yasushi Sasaki
Publication date: 01-09-2007
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 9/2007
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-007-9140-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

What is the role of regulatory T cells in the success of implantation and early pregnancy?

Abstract

Problem

Methods

Results and conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Problem

Methods

Results and conclusions

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