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Published in: International Ophthalmology 10/2020

01-10-2020 | Edema | Original Paper

Association between the patterns of diabetic macular edema and photoreceptors’ response after intravitreal ranibizumab treatment: a spectral-domain optical coherence tomography study

Authors: Irini Chatziralli, George Theodossiadis, Eleni Dimitriou, Dimitrios Kazantzis, Panagiotis Theodossiadis

Published in: International Ophthalmology | Issue 10/2020

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Abstract

Purpose

To analyze photoreceptors’ condition after intravitreal ranibizumab treatment according to the pattern of diabetic macular edema (DME) on spectral-domain optical coherence tomography (SD-OCT).

Methods

Retrospective study includes 58 treatment naïve patients with DME, treated with intravitreal ranibizumab injections and followed up for at least 12 months. Patients were classified based on DME morphology on SD-OCT into: diffuse macular edema, cystoid macular edema (CME) and serous retinal detachment with CME (SRD/CME). The DME morphology was analyzed, while quantitative measurement of ellipsoid zone (EZ) defect, as well as qualitative assessment of the condition of external limiting membrane (ELM) and interdigitation zone (IZ) at foveal area, was taken before and after treatment.

Results

Before treatment, patients with CME presented worse ELM and IZ condition and greater EZ defect than patients with diffuse macular edema or SRD/CME. After treatment, the restoration of EZ defect and IZ was more evident in patients with CME than in diffuse macular edema or SRD/CME.

Conclusion

Patients with DME presented significant photoreceptors’ restoration after intravitreal ranibizumab injections at the 12-month follow-up. The improvement in EZ defect size and IZ was dependent on the pattern of DME on SD-OCT.
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Metadata
Title
Association between the patterns of diabetic macular edema and photoreceptors’ response after intravitreal ranibizumab treatment: a spectral-domain optical coherence tomography study
Authors
Irini Chatziralli
George Theodossiadis
Eleni Dimitriou
Dimitrios Kazantzis
Panagiotis Theodossiadis
Publication date
01-10-2020
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 10/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01423-3

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