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01-09-2020 | Original Paper

Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy

Authors: Giamberto Casini, Michele Marinò, Marisa Rubino, Serena Licari, Giuseppe Covello, Barbara Mazzi, Ilaria Ionni, Roberto Rocchi, Angela Tindara Sframeli, Michele Figus, Pasquale Loiudice

Published in: International Ophthalmology | Issue 9/2020

Abstract

Purpose

To compare optic disc, retinal and choroidal measurements in patients with Graves’ disease with or without orbitopathy, and healthy controls.

Methods

Optical coherence tomography and Heidelberg retinal tomography were performed in 40 patients with Graves’ orbitopathy (GO), 40 subjects with Graves’s disease (GD) with no sign of orbitopathy and 40 healthy controls. Degree of exophthalmos, ocular alignment, clinical activity score (CAS), choroidal thickness, retinal thickness, ganglion cell layer (GCL) thickness, disc area, cup area, rim area, cup/disc area ratio, linear cup/disc ratio and mean peripapillary retinal nerve fibre layer thickness were analysed.

Results

GO patients and healthy controls significantly differ regarding mean central retinal thickness (275 ± 19 µm and 285 ± 20 µm, P = 0.017); mean central GCL thickness (14.87 ± 3.0 µm and 17.92 ± 5.02 µm, P = 0.001); mean disc area (2.00 ± 0.44 mm² and 1.72 ± 0.37 mm², P = 0.003); mean cup area (0.53 ± 0.52 mm² and 0.31 ± 0.20 mm², P = 0.003); cup/disc area ratio (0.22 ± 0.10 and 0.17 ± 0.08, P = 0.010); and linear cup/disc ratio (0.47 ± 0.15 and 0.40 ± 0.13, respectively, P = 0.011). No difference was found between patients without orbitopathy and healthy controls. No significant difference was found regarding the choroidal thickness between the three groups. There was no statistically significant relationship between retinal thickness, ganglion cell layer thickness, mean disc area, mean cup area, cup/disc area ratio, linear cup/disc ratio, CAS, exophthalmometric value and ocular alignment.

Conclusion

GO patients showed significant changes in foveal and GCL thickness, and optic nerve head morphology suggesting a possible influence of the orbital inflammatory process.

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Title: Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy
Authors: Giamberto Casini
Michele Marinò
Marisa Rubino
Serena Licari
Giuseppe Covello
Barbara Mazzi
Ilaria Ionni
Roberto Rocchi
Angela Tindara Sframeli
Michele Figus
Pasquale Loiudice
Publication date: 01-09-2020
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 9/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01392-7

ACC 2024 Congress

Springer Medicine

Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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