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Published in: International Ophthalmology 4/2020

01-04-2020 | Night-Blindness | Review

Ocular manifestations in celiac disease: an overview

Authors: Fotios S. Fousekis, Andreas Katsanos, Konstantinos H. Katsanos, Dimitrios K. Christodoulou

Published in: International Ophthalmology | Issue 4/2020

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Abstract

Purpose

To review and highlight the ocular manifestations associated with celiac disease (CD) and presentation of their pathogenetic mechanisms.

Methods

A thorough review of the literature was performed using PubMed to identify articles about serrated polyposis syndrome. The search was performed using the search string: (“celiac disease” OR “coeliac disease”) AND (“ocular manifestations” OR “eye” OR “orbitopathy” OR “uveitis” OR “neuro-ophthalmic manifestations”). Only articles in English were reviewed.

Results

Several ocular symptoms and disorders have been associated with CD and are a result of defective intestinal absorption and immunological mechanisms. These include nyctalopia, dry eye, cataract, thyroid-associated orbitopathy, uveitis, central retinal vein occlusion and neuro-ophthalmic manifestations. In addition, CD-related ocular disease may represent the first manifestation of CD.

Conclusion

CD may hold accountable for the development of ocular diseases of obscure etiology.
Literature
1.
go back to reference Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE (2012) The prevalence of celiac disease in the United States. Am J Gastroenterol 107(10):1538–1544 (quiz 7, 45) PubMed Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE (2012) The prevalence of celiac disease in the United States. Am J Gastroenterol 107(10):1538–1544 (quiz 7, 45) PubMed
2.
go back to reference Singh P, Arora S, Singh A, Strand TA, Makharia GK (2016) Prevalence of celiac disease in Asia: a systematic review and meta-analysis. J Gastroenterol Hepatol 31(6):1095–1101PubMed Singh P, Arora S, Singh A, Strand TA, Makharia GK (2016) Prevalence of celiac disease in Asia: a systematic review and meta-analysis. J Gastroenterol Hepatol 31(6):1095–1101PubMed
3.
go back to reference Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA, American College of G (2013) ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 108(5):656–676 (quiz 77) PubMedPubMedCentral Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA, American College of G (2013) ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 108(5):656–676 (quiz 77) PubMedPubMedCentral
4.
go back to reference Laurikka P, Nurminen S, Kivela L, Kurppa K (2018) Extraintestinal manifestations of celiac disease: early detection for better long-term outcomes. Nutrients 10(8):1015PubMedCentral Laurikka P, Nurminen S, Kivela L, Kurppa K (2018) Extraintestinal manifestations of celiac disease: early detection for better long-term outcomes. Nutrients 10(8):1015PubMedCentral
5.
go back to reference Martins TG, Costa AL, Oyamada MK, Schor P, Sipahi AM (2016) Ophthalmologic manifestations of celiac disease. Int J Ophthalmol 9(1):159–162PubMedPubMedCentral Martins TG, Costa AL, Oyamada MK, Schor P, Sipahi AM (2016) Ophthalmologic manifestations of celiac disease. Int J Ophthalmol 9(1):159–162PubMedPubMedCentral
6.
go back to reference Karatepe Hashas AS, Altunel O, Sevinc E, Duru N, Alabay B, Torun YA (2017) The eyes of children with celiac disease. J AAPOS 21(1):48–51PubMed Karatepe Hashas AS, Altunel O, Sevinc E, Duru N, Alabay B, Torun YA (2017) The eyes of children with celiac disease. J AAPOS 21(1):48–51PubMed
7.
go back to reference Uzel MM, Citirik M, Kekilli M, Cicek P (2017) Local ocular surface parameters in patients with systemic celiac disease. Eye 31(7):1093–1098PubMedPubMedCentral Uzel MM, Citirik M, Kekilli M, Cicek P (2017) Local ocular surface parameters in patients with systemic celiac disease. Eye 31(7):1093–1098PubMedPubMedCentral
8.
go back to reference Tokgoz Y, Terlemez S, Karul A (2018) Fat soluble vitamin levels in children with newly diagnosed celiac disease, a case control study. BMC Pediatr 18(1):130PubMedPubMedCentral Tokgoz Y, Terlemez S, Karul A (2018) Fat soluble vitamin levels in children with newly diagnosed celiac disease, a case control study. BMC Pediatr 18(1):130PubMedPubMedCentral
9.
go back to reference Erdem T, Ferat C, Nurdan YA, Halime E, Muhammed Selcuk S, Hamza K et al (2015) Vitamin and mineral deficiency in children newly diagnosed with celiac disease. Turk J Med Sci 45(4):833–836PubMed Erdem T, Ferat C, Nurdan YA, Halime E, Muhammed Selcuk S, Hamza K et al (2015) Vitamin and mineral deficiency in children newly diagnosed with celiac disease. Turk J Med Sci 45(4):833–836PubMed
10.
go back to reference Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA (2013) Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 5(10):3975–3992PubMedPubMedCentral Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA (2013) Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 5(10):3975–3992PubMedPubMedCentral
12.
go back to reference Alwitry A (2000) Vitamin A deficiency in coeliac disease. Br J Ophthalmol 84(9):1079–1080PubMed Alwitry A (2000) Vitamin A deficiency in coeliac disease. Br J Ophthalmol 84(9):1079–1080PubMed
13.
go back to reference Witherspoon SR, Callanan D (2008) Celiac disease presenting as a xerophthalmic fundus. Retina 28(3):525–526PubMed Witherspoon SR, Callanan D (2008) Celiac disease presenting as a xerophthalmic fundus. Retina 28(3):525–526PubMed
14.
go back to reference Chiu M, Dillon A, Watson S (2016) Vitamin A deficiency and xerophthalmia in children of a developed country. J Paediatr Child Health 52(7):699–703PubMed Chiu M, Dillon A, Watson S (2016) Vitamin A deficiency and xerophthalmia in children of a developed country. J Paediatr Child Health 52(7):699–703PubMed
15.
go back to reference Apushkin MA, Fishman GA (2005) Improvement in visual function and fundus findings for a patient with vitamin A-deficient retinopathy. Retina 25(5):650–652PubMed Apushkin MA, Fishman GA (2005) Improvement in visual function and fundus findings for a patient with vitamin A-deficient retinopathy. Retina 25(5):650–652PubMed
16.
go back to reference McGeeney BE, Friedman DI (2014) Pseudotumor cerebri pathophysiology. Headache 54(3):445–458PubMed McGeeney BE, Friedman DI (2014) Pseudotumor cerebri pathophysiology. Headache 54(3):445–458PubMed
17.
go back to reference Hayes KC, McCombs HL, Faherty TP (1971) The fine structure of vitamin A deficiency. II. Arachnoid granulations and CSF pressure. Brain J Neurol 94(2):213–224 Hayes KC, McCombs HL, Faherty TP (1971) The fine structure of vitamin A deficiency. II. Arachnoid granulations and CSF pressure. Brain J Neurol 94(2):213–224
18.
go back to reference Calhoun MC, Hurt HD, Eaton HD, Rousseau JE Jr, Hall RC Jr (1967) Rates of formation and absorption of cerebrospinal fluid in bovine hypovitaminosis A. J Dairy Sci 50(9):1489–1494PubMed Calhoun MC, Hurt HD, Eaton HD, Rousseau JE Jr, Hall RC Jr (1967) Rates of formation and absorption of cerebrospinal fluid in bovine hypovitaminosis A. J Dairy Sci 50(9):1489–1494PubMed
19.
go back to reference Libien J, Kupersmith MJ, Blaner W, McDermott MP, Gao S, Liu Y et al (2017) Role of vitamin A metabolism in IIH: results from the idiopathic intracranial hypertension treatment trial. J Neurol Sci 372:78–84PubMed Libien J, Kupersmith MJ, Blaner W, McDermott MP, Gao S, Liu Y et al (2017) Role of vitamin A metabolism in IIH: results from the idiopathic intracranial hypertension treatment trial. J Neurol Sci 372:78–84PubMed
20.
go back to reference Dotan G, Goldstein M, Stolovitch C, Kesler A (2013) Pediatric pseudotumor cerebri associated with low serum levels of vitamin A. J Child Neurol 28(11):1370–1377PubMed Dotan G, Goldstein M, Stolovitch C, Kesler A (2013) Pediatric pseudotumor cerebri associated with low serum levels of vitamin A. J Child Neurol 28(11):1370–1377PubMed
21.
22.
go back to reference Raina UK, Goel N, Sud R, Thakar M, Ghosh B (2011) Bilateral total cataract as the presenting feature of celiac disease. Int Ophthalmol 31(1):47–50PubMed Raina UK, Goel N, Sud R, Thakar M, Ghosh B (2011) Bilateral total cataract as the presenting feature of celiac disease. Int Ophthalmol 31(1):47–50PubMed
23.
go back to reference Sari R, Yildirim B, Sevinc A, Buyukberber S (2000) Idiopathic hypoparathyroidism and celiac disease in two patients with previous history of cataract. Indian J Gastroenterol 19(1):31–32PubMed Sari R, Yildirim B, Sevinc A, Buyukberber S (2000) Idiopathic hypoparathyroidism and celiac disease in two patients with previous history of cataract. Indian J Gastroenterol 19(1):31–32PubMed
24.
go back to reference Rickels MR, Mandel SJ (2004) Celiac disease manifesting as isolated hypocalcemia. Endocr Pract 10(3):203–207PubMed Rickels MR, Mandel SJ (2004) Celiac disease manifesting as isolated hypocalcemia. Endocr Pract 10(3):203–207PubMed
25.
26.
go back to reference Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2015) The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res 30(9):1738–1744PubMed Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2015) The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res 30(9):1738–1744PubMed
27.
go back to reference Alzaben AS, Turner J, Shirton L, Samuel TM, Persad R, Mager D (2015) Assessing nutritional quality and adherence to the gluten-free diet in children and adolescents with celiac disease. Can J Diet Pract Res 76(2):56–63PubMed Alzaben AS, Turner J, Shirton L, Samuel TM, Persad R, Mager D (2015) Assessing nutritional quality and adherence to the gluten-free diet in children and adolescents with celiac disease. Can J Diet Pract Res 76(2):56–63PubMed
28.
go back to reference Reinken L, Zieglauer H (1978) Vitamin B-6 absorption in children with acute celiac disease and in control subjects. J Nutr 108(10):1562–1565PubMed Reinken L, Zieglauer H (1978) Vitamin B-6 absorption in children with acute celiac disease and in control subjects. J Nutr 108(10):1562–1565PubMed
29.
go back to reference Mooney PD, Kurien M, Evans KE, Rosario E, Cross SS, Vergani P et al (2016) Clinical and immunologic features of ultra-short celiac disease. Gastroenterology 150(5):1125–1134PubMed Mooney PD, Kurien M, Evans KE, Rosario E, Cross SS, Vergani P et al (2016) Clinical and immunologic features of ultra-short celiac disease. Gastroenterology 150(5):1125–1134PubMed
30.
go back to reference Post M, Lubinski W, Lubinski J, Krzystolik K, Baszuk P, Muszynska M et al (2018) Serum selenium levels are associated with age-related cataract. Ann Agric Environ Med 25(3):443–448PubMed Post M, Lubinski W, Lubinski J, Krzystolik K, Baszuk P, Muszynska M et al (2018) Serum selenium levels are associated with age-related cataract. Ann Agric Environ Med 25(3):443–448PubMed
31.
go back to reference Ajith TA (2015) Ranimenon. Homocysteine in ocular diseases. Clin Chim Acta 450:316–321PubMed Ajith TA (2015) Ranimenon. Homocysteine in ocular diseases. Clin Chim Acta 450:316–321PubMed
32.
go back to reference Minassian DC, Mehra V, Jones BR (1984) Dehydrational crises from severe diarrhoea or heatstroke and risk of cataract. Lancet 1(8380):751–753PubMed Minassian DC, Mehra V, Jones BR (1984) Dehydrational crises from severe diarrhoea or heatstroke and risk of cataract. Lancet 1(8380):751–753PubMed
33.
go back to reference Balasubramanian D, Bansal AK, Basti S, Bhatt KS, Murthy JS, Rao CM (1993) The biology of cataract. The Hyderabad cataract research group. Indian J Ophthalmol 41(4):153–171PubMed Balasubramanian D, Bansal AK, Basti S, Bhatt KS, Murthy JS, Rao CM (1993) The biology of cataract. The Hyderabad cataract research group. Indian J Ophthalmol 41(4):153–171PubMed
34.
go back to reference Mollazadegan K, Kugelberg M, Lindblad BE, Ludvigsson JF (2011) Increased risk of cataract among 28,000 patients with celiac disease. Am J Epidemiol 174(2):195–202PubMed Mollazadegan K, Kugelberg M, Lindblad BE, Ludvigsson JF (2011) Increased risk of cataract among 28,000 patients with celiac disease. Am J Epidemiol 174(2):195–202PubMed
36.
go back to reference Roy A, Laszkowska M, Sundstrom J, Lebwohl B, Green PH, Kampe O et al (2016) Prevalence of celiac disease in patients with autoimmune thyroid disease: a meta-analysis. Thyroid 26(7):880–890PubMed Roy A, Laszkowska M, Sundstrom J, Lebwohl B, Green PH, Kampe O et al (2016) Prevalence of celiac disease in patients with autoimmune thyroid disease: a meta-analysis. Thyroid 26(7):880–890PubMed
37.
go back to reference Mormile R (2016) Celiac disease and Hashimoto’s thyroiditis: a shared plot? Int J Colorectal Dis 31(4):947PubMed Mormile R (2016) Celiac disease and Hashimoto’s thyroiditis: a shared plot? Int J Colorectal Dis 31(4):947PubMed
39.
go back to reference Ponto KA, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T et al (2014) Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol 178(1):57–64PubMedPubMedCentral Ponto KA, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T et al (2014) Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol 178(1):57–64PubMedPubMedCentral
40.
go back to reference Ferrari SM, Fallahi P, Ruffilli I, Elia G, Ragusa F, Benvenga S et al (2019) The association of other autoimmune diseases in patients with Graves’ disease (with or without ophthalmopathy): review of the literature and report of a large series. Autoimmun Rev 18(3):287–292PubMed Ferrari SM, Fallahi P, Ruffilli I, Elia G, Ragusa F, Benvenga S et al (2019) The association of other autoimmune diseases in patients with Graves’ disease (with or without ophthalmopathy): review of the literature and report of a large series. Autoimmun Rev 18(3):287–292PubMed
41.
go back to reference Kapoor A, Patwari AK, Kumar P, Jain A, Narayan S (2013) Serum soluble interleukin-2 receptor, interleukin-6 and tumor necrosis factor alpha as markers of celiac disease activity. Indian J Pediatr 80(2):108–113PubMed Kapoor A, Patwari AK, Kumar P, Jain A, Narayan S (2013) Serum soluble interleukin-2 receptor, interleukin-6 and tumor necrosis factor alpha as markers of celiac disease activity. Indian J Pediatr 80(2):108–113PubMed
42.
go back to reference Mikos H, Mikos M, Obara-Moszynska M, Niedziela M (2014) The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease (AITD). Endokrynol Polska 65(2):150–155 Mikos H, Mikos M, Obara-Moszynska M, Niedziela M (2014) The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease (AITD). Endokrynol Polska 65(2):150–155
43.
go back to reference Pras E, Neumann R, Zandman-Goddard G, Levy Y, Assia EI, Shoenfeld Y et al (2004) Intraocular inflammation in autoimmune diseases. Semin Arthritis Rheum 34(3):602–609PubMed Pras E, Neumann R, Zandman-Goddard G, Levy Y, Assia EI, Shoenfeld Y et al (2004) Intraocular inflammation in autoimmune diseases. Semin Arthritis Rheum 34(3):602–609PubMed
44.
go back to reference Klack K, Pereira RM, de Carvalho JF (2011) Uveitis in celiac disease with an excellent response to gluten-free diet: third case described. Rheumatol Int 31(3):399–402PubMed Klack K, Pereira RM, de Carvalho JF (2011) Uveitis in celiac disease with an excellent response to gluten-free diet: third case described. Rheumatol Int 31(3):399–402PubMed
45.
go back to reference Krifa F, Knani L, Sakly W, Ghedira I, Essoussi AS, Boukadida J et al (2010) Uveitis responding on gluten free diet in a girl with celiac disease and diabetes mellitus type 1. Gastroenterol Clin Biol 34(4–5):319–320PubMed Krifa F, Knani L, Sakly W, Ghedira I, Essoussi AS, Boukadida J et al (2010) Uveitis responding on gluten free diet in a girl with celiac disease and diabetes mellitus type 1. Gastroenterol Clin Biol 34(4–5):319–320PubMed
46.
go back to reference Hyrailles V, Desprez D, Beauerere L, de Ferrier F, Larrey D, Ramos J et al (1995) Uveitis complicating celiac disease and cured by gluten-free diet. Gastroenterol Clin Biol 19(5):543–544PubMed Hyrailles V, Desprez D, Beauerere L, de Ferrier F, Larrey D, Ramos J et al (1995) Uveitis complicating celiac disease and cured by gluten-free diet. Gastroenterol Clin Biol 19(5):543–544PubMed
47.
go back to reference Mollazadegan K, Kugelberg M, Tallstedt L, Ludvigsson JF (2012) Increased risk of uveitis in coeliac disease: a nationwide cohort study. Br J Ophthalmol 96(6):857–861PubMed Mollazadegan K, Kugelberg M, Tallstedt L, Ludvigsson JF (2012) Increased risk of uveitis in coeliac disease: a nationwide cohort study. Br J Ophthalmol 96(6):857–861PubMed
48.
go back to reference Rosenbaum JT, Lin P, Asquith M (2016) The microbiome, HLA, and the pathogenesis of uveitis. Jpn J Ophthalmol 60(1):1–6PubMed Rosenbaum JT, Lin P, Asquith M (2016) The microbiome, HLA, and the pathogenesis of uveitis. Jpn J Ophthalmol 60(1):1–6PubMed
49.
go back to reference Weinstein JE, Pepple KL (2018) Cytokines in uveitis. Curr Opin Ophthalmol 29(3):267–274PubMed Weinstein JE, Pepple KL (2018) Cytokines in uveitis. Curr Opin Ophthalmol 29(3):267–274PubMed
50.
go back to reference Casella G, Bordo BM, Schalling R, Villanacci V, Salemme M, Di Bella C et al (2016) Neurological disorders and celiac disease. Minerva Gastroenterol Dietol 62(2):197–206PubMed Casella G, Bordo BM, Schalling R, Villanacci V, Salemme M, Di Bella C et al (2016) Neurological disorders and celiac disease. Minerva Gastroenterol Dietol 62(2):197–206PubMed
51.
go back to reference Arroyo HA, De Rosa S, Ruggieri V, de Davila MT, Fejerman N, Argentinean E et al (2002) Epilepsy, occipital calcifications, and oligosymptomatic celiac disease in childhood. J Child Neurol 17(11):800–806PubMed Arroyo HA, De Rosa S, Ruggieri V, de Davila MT, Fejerman N, Argentinean E et al (2002) Epilepsy, occipital calcifications, and oligosymptomatic celiac disease in childhood. J Child Neurol 17(11):800–806PubMed
52.
go back to reference Millington RS, James-Galton M, Barbur JL, Plant GT, Bridge H (2015) Severe, persistent visual impairment associated with occipital calcification and coeliac disease. J Neurol 262(9):2056–2063PubMed Millington RS, James-Galton M, Barbur JL, Plant GT, Bridge H (2015) Severe, persistent visual impairment associated with occipital calcification and coeliac disease. J Neurol 262(9):2056–2063PubMed
53.
go back to reference Wu D, Pardridge WM (1999) Blood-brain barrier transport of reduced folic acid. Pharm Res 16(3):415–419PubMed Wu D, Pardridge WM (1999) Blood-brain barrier transport of reduced folic acid. Pharm Res 16(3):415–419PubMed
54.
go back to reference Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C et al (2019) Cerebral folate deficiency in adults: a heterogeneous potentially treatable condition. J Neurol Sci 396:112–118PubMed Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C et al (2019) Cerebral folate deficiency in adults: a heterogeneous potentially treatable condition. J Neurol Sci 396:112–118PubMed
55.
go back to reference Bernasconi A, Bernasconi N, Andermann F, Dubeau F, Guberman A, Gobbi G et al (1998) Celiac disease, bilateral occipital calcifications and intractable epilepsy: mechanisms of seizure origin. Epilepsia 39(3):300–306PubMed Bernasconi A, Bernasconi N, Andermann F, Dubeau F, Guberman A, Gobbi G et al (1998) Celiac disease, bilateral occipital calcifications and intractable epilepsy: mechanisms of seizure origin. Epilepsia 39(3):300–306PubMed
56.
go back to reference Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders DS, Woodroofe N, Aeschlimann D (2008) Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Ann Neurol 64(3):332–343PubMed Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders DS, Woodroofe N, Aeschlimann D (2008) Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Ann Neurol 64(3):332–343PubMed
57.
go back to reference Johnson AM, Dale RC, Wienholt L, Hadjivassiliou M, Aeschlimann D, Lawson JA (2013) Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies. Dev Med Child Neurol 55(1):90–93PubMed Johnson AM, Dale RC, Wienholt L, Hadjivassiliou M, Aeschlimann D, Lawson JA (2013) Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies. Dev Med Child Neurol 55(1):90–93PubMed
58.
go back to reference Patterson SL, Goglin SE (2017) Neuromyelitis optica. Rheum Dis Clin N Am 43(4):579–591 Patterson SL, Goglin SE (2017) Neuromyelitis optica. Rheum Dis Clin N Am 43(4):579–591
59.
go back to reference Jarius S, Wildemann B (2010) AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 6(7):383–392PubMed Jarius S, Wildemann B (2010) AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 6(7):383–392PubMed
60.
go back to reference Sellner J, Boggild M, Clanet M, Hintzen RQ, Illes Z, Montalban X et al (2010) EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol 17(8):1019–1032PubMed Sellner J, Boggild M, Clanet M, Hintzen RQ, Illes Z, Montalban X et al (2010) EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol 17(8):1019–1032PubMed
61.
go back to reference Jacob S, Zarei M, Kenton A, Allroggen H (2005) Gluten sensitivity and neuromyelitis optica: two case reports. J Neurol Neurosurg Psychiatry 76(7):1028–1030PubMedPubMedCentral Jacob S, Zarei M, Kenton A, Allroggen H (2005) Gluten sensitivity and neuromyelitis optica: two case reports. J Neurol Neurosurg Psychiatry 76(7):1028–1030PubMedPubMedCentral
62.
go back to reference Bergamaschi R, Jarius S, Robotti M, Pichiecchio A, Wildemann B, Meola G (2009) Two cases of benign neuromyelitis optica in patients with celiac disease. J Neurol 256(12):2097–2099PubMed Bergamaschi R, Jarius S, Robotti M, Pichiecchio A, Wildemann B, Meola G (2009) Two cases of benign neuromyelitis optica in patients with celiac disease. J Neurol 256(12):2097–2099PubMed
63.
go back to reference Jarius S, Jacob S, Waters P, Jacob A, Littleton E, Vincent A (2008) Neuromyelitis optica in patients with gluten sensitivity associated with antibodies to aquaporin-4. J Neurol Neurosurg Psychiatry 79(9):1084PubMed Jarius S, Jacob S, Waters P, Jacob A, Littleton E, Vincent A (2008) Neuromyelitis optica in patients with gluten sensitivity associated with antibodies to aquaporin-4. J Neurol Neurosurg Psychiatry 79(9):1084PubMed
64.
go back to reference Meyts I, Jansen K, Renard M, Bossuyt X, Roelens F, Regal L et al (2011) Neuromyelitis optica-IgG + optic neuritis associated with celiac disease and dysgammaglobulinemia: a role for tacrolimus? Eur J Paediatr Neurol 15(3):265–267PubMed Meyts I, Jansen K, Renard M, Bossuyt X, Roelens F, Regal L et al (2011) Neuromyelitis optica-IgG + optic neuritis associated with celiac disease and dysgammaglobulinemia: a role for tacrolimus? Eur J Paediatr Neurol 15(3):265–267PubMed
65.
go back to reference Danielsson O, Lindvall B, Hallert C, Vrethem M, Dahle C (2017) Increased prevalence of celiac disease in idiopathic inflammatory myopathies. Brain Behav 7(10):e00803PubMedPubMedCentral Danielsson O, Lindvall B, Hallert C, Vrethem M, Dahle C (2017) Increased prevalence of celiac disease in idiopathic inflammatory myopathies. Brain Behav 7(10):e00803PubMedPubMedCentral
66.
go back to reference Cerman E, Esen F, Eraslan M, Kazokoglu H (2014) Orbital myositis associated with celiac disease. Int Ophthalmol 34(3):635–638PubMed Cerman E, Esen F, Eraslan M, Kazokoglu H (2014) Orbital myositis associated with celiac disease. Int Ophthalmol 34(3):635–638PubMed
67.
go back to reference Katsanos A, Asproudis I, Katsanos KH, Dastiridou AI, Aspiotis M, Tsianos EV (2013) Orbital and optic nerve complications of inflammatory bowel disease. J Crohn’s Colitis 7(9):683–693 Katsanos A, Asproudis I, Katsanos KH, Dastiridou AI, Aspiotis M, Tsianos EV (2013) Orbital and optic nerve complications of inflammatory bowel disease. J Crohn’s Colitis 7(9):683–693
68.
go back to reference Felekis T, Katsanos K, Kitsanou M, Trakos N, Theopistos V, Christodoulou D et al (2009) Spectrum and frequency of ophthalmologic manifestations in patients with inflammatory bowel disease: a prospective single-center study. Inflamm Bowel Dis 15(1):29–34PubMed Felekis T, Katsanos K, Kitsanou M, Trakos N, Theopistos V, Christodoulou D et al (2009) Spectrum and frequency of ophthalmologic manifestations in patients with inflammatory bowel disease: a prospective single-center study. Inflamm Bowel Dis 15(1):29–34PubMed
69.
go back to reference Lerner A, Blank M (2014) Hypercoagulability in celiac disease–an update. Autoimmun Rev 13(11):1138–1141PubMed Lerner A, Blank M (2014) Hypercoagulability in celiac disease–an update. Autoimmun Rev 13(11):1138–1141PubMed
70.
go back to reference Malhi RK, Dhami A, Malhi NS, Soni A, Dhami GS (2018) Central retinal vein occlusion revealing celiac disease: the first report of two cases from India. Indian J Ophthalmol 66(9):1315–1317PubMedPubMedCentral Malhi RK, Dhami A, Malhi NS, Soni A, Dhami GS (2018) Central retinal vein occlusion revealing celiac disease: the first report of two cases from India. Indian J Ophthalmol 66(9):1315–1317PubMedPubMedCentral
71.
go back to reference Jomni T, Bellakhal S, Abouda M, Abdelaali I, Douggui H (2015) An atypical presentation of celiac disease: central retinal vein occlusion. Pan Afr Med J 22:300PubMedPubMedCentral Jomni T, Bellakhal S, Abouda M, Abdelaali I, Douggui H (2015) An atypical presentation of celiac disease: central retinal vein occlusion. Pan Afr Med J 22:300PubMedPubMedCentral
72.
go back to reference Lee ES, Pulido JS (2005) Nonischemic central retinal vein occlusion associated with celiac disease. Mayo Clin Proc 80(2):157PubMed Lee ES, Pulido JS (2005) Nonischemic central retinal vein occlusion associated with celiac disease. Mayo Clin Proc 80(2):157PubMed
Metadata
Title
Ocular manifestations in celiac disease: an overview
Authors
Fotios S. Fousekis
Andreas Katsanos
Konstantinos H. Katsanos
Dimitrios K. Christodoulou
Publication date
01-04-2020
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 4/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01254-x

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