Skip to main content
Top
Published in: International Ophthalmology 2/2020

01-02-2020 | Glaucoma | Original Paper

Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects

Authors: Gonzalo Carracedo-Rodríguez, Alejandro Martínez-Águila, Candela Rodriguez-Pomar, Julia Bodas-Romero, Juan Sanchez-Naves, Jesús Pintor

Published in: International Ophthalmology | Issue 2/2020

Login to get access

Abstract

Purpose

To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.

Patients and methods

A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (n = 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (n = 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.

Results

The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (p value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (p value < 0.001).

Conclusion

The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.
Literature
1.
go back to reference Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I (2012) Definition of glaucoma: clinical and experimental concepts. Clin Exp Ophthalmol 40(4):341–349CrossRef Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I (2012) Definition of glaucoma: clinical and experimental concepts. Clin Exp Ophthalmol 40(4):341–349CrossRef
2.
go back to reference Alarma-Estrany P, Pintor J (2007) Melatonin receptors in the eye: location, second messengers and role in ocular physiology. Pharmacol Ther 113(3):507–522CrossRef Alarma-Estrany P, Pintor J (2007) Melatonin receptors in the eye: location, second messengers and role in ocular physiology. Pharmacol Ther 113(3):507–522CrossRef
3.
go back to reference Osborne NN (1994) Serotonin and melatonin in the iris/ciliary processes and their involvement in intraocular pressure. Acta Neurobiol Exp (Wars) 54(Suppl):57–64 Osborne NN (1994) Serotonin and melatonin in the iris/ciliary processes and their involvement in intraocular pressure. Acta Neurobiol Exp (Wars) 54(Suppl):57–64
4.
go back to reference Martinez-Aguila A, Fonseca B, Bergua A, Pintor J (2013) Melatonin analogue agomelatine reduces rabbit’s intraocular pressure in normotensive and hypertensive conditions. Eur J Pharmacol 701(1–3):213–217CrossRef Martinez-Aguila A, Fonseca B, Bergua A, Pintor J (2013) Melatonin analogue agomelatine reduces rabbit’s intraocular pressure in normotensive and hypertensive conditions. Eur J Pharmacol 701(1–3):213–217CrossRef
5.
go back to reference Mediero A, Alarma-Estrany P, Pintor J (2009) New treatments for ocular hypertension. Auton Neurosci 147(1–2):14–19CrossRef Mediero A, Alarma-Estrany P, Pintor J (2009) New treatments for ocular hypertension. Auton Neurosci 147(1–2):14–19CrossRef
6.
go back to reference Pescosolido N, Gatto V, Stefanucci A, Rusciano D (2015) Oral treatment with the melatonin agonist agomelatine lowers the intraocular pressure of glaucoma patients. Ophthalmic Physiol Opt 35(2):201–205CrossRef Pescosolido N, Gatto V, Stefanucci A, Rusciano D (2015) Oral treatment with the melatonin agonist agomelatine lowers the intraocular pressure of glaucoma patients. Ophthalmic Physiol Opt 35(2):201–205CrossRef
7.
go back to reference Ismail SA, Mowafi HA (2009) Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth Analg 108(4):1146–1151CrossRef Ismail SA, Mowafi HA (2009) Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth Analg 108(4):1146–1151CrossRef
8.
go back to reference Samples JR, Krause G, Lewy AJ (1988) Effect of melatonin on intraocular pressure. Curr Eye Res 7(7):649–653CrossRef Samples JR, Krause G, Lewy AJ (1988) Effect of melatonin on intraocular pressure. Curr Eye Res 7(7):649–653CrossRef
9.
go back to reference Majsterek I, Malinowska K, Stanczyk M, Kowalski M, Blaszczyk J, Kurowska AK, Kaminska A, Szaflik J, Szaflik JP (2011) Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma. Exp Mol Pathol 90(2):231–237CrossRef Majsterek I, Malinowska K, Stanczyk M, Kowalski M, Blaszczyk J, Kurowska AK, Kaminska A, Szaflik J, Szaflik JP (2011) Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma. Exp Mol Pathol 90(2):231–237CrossRef
10.
go back to reference Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, Reiter RJ (2003) Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 34(1):75–78CrossRef Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, Reiter RJ (2003) Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 34(1):75–78CrossRef
11.
go back to reference World Medical Association (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191–2194CrossRef World Medical Association (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191–2194CrossRef
12.
go back to reference Hellmann H, Mooney S (2010) Vitamin B6: a molecule for human health? Molecules 15(1):442–459CrossRef Hellmann H, Mooney S (2010) Vitamin B6: a molecule for human health? Molecules 15(1):442–459CrossRef
13.
go back to reference Ohguro H, Ohguro I, Yagi S (2013) Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma. J Ocul Pharmacol Ther 29(1):61–67CrossRef Ohguro H, Ohguro I, Yagi S (2013) Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma. J Ocul Pharmacol Ther 29(1):61–67CrossRef
14.
go back to reference Sudesh S, Moseley MJ, Thompson JR (1993) Accuracy of Goldmann tonometry in clinical practice. Acta Ophthalmol 71(2):185–188CrossRef Sudesh S, Moseley MJ, Thompson JR (1993) Accuracy of Goldmann tonometry in clinical practice. Acta Ophthalmol 71(2):185–188CrossRef
15.
go back to reference Ogbuehi KC, Almubrad TM (2008) Accuracy and reliability of the Keeler Pulsair EasyEye non-contact tonometer. Optom Vis Sci 85(1):61–66CrossRef Ogbuehi KC, Almubrad TM (2008) Accuracy and reliability of the Keeler Pulsair EasyEye non-contact tonometer. Optom Vis Sci 85(1):61–66CrossRef
Metadata
Title
Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects
Authors
Gonzalo Carracedo-Rodríguez
Alejandro Martínez-Águila
Candela Rodriguez-Pomar
Julia Bodas-Romero
Juan Sanchez-Naves
Jesús Pintor
Publication date
01-02-2020
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 2/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01199-1

Other articles of this Issue 2/2020

International Ophthalmology 2/2020 Go to the issue