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International Ophthalmology

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01-07-2019 | Case Report

The tarsal plate manifestation of IgG4-related disease

Authors: J. S. N. Verhoekx, A. F. Karim, J. A. M. van Laar, R. M. Verdijk, D. Paridaens

Published in: International Ophthalmology | Issue 7/2019

Abstract

Purpose

To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.

Method

Interventional case report.

Results

A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.

Conclusions

Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

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Title: The tarsal plate manifestation of IgG4-related disease
Authors: J. S. N. Verhoekx
A. F. Karim
J. A. M. van Laar
R. M. Verdijk
D. Paridaens
Publication date: 01-07-2019
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 7/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0974-3

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Springer Medicine

The tarsal plate manifestation of IgG4-related disease

Abstract

Purpose

Method

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusions

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