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Published in: International Ophthalmology 6/2019

01-06-2019 | Case Report

Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever

Authors: Assaf Hilely, Guy Kleinmann

Published in: International Ophthalmology | Issue 6/2019

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Abstract

Purpose

To report a rare case of spontaneous corneal perforation after hydrops in keratoconus patients who suffer from familial Mediterranean fever and was treated systemically with Colchicine.

Methods

Case report.

Results

We report a case of a 30-year-old male with keratoconus and familial Mediterranean fever treated with colchicine, presented with acute hydrops in his left eye, which progressed to a spontaneous corneal perforation. Attempts to treat the perforation with cyanoacrylate glue failed, and he underwent penetrating keratoplasty with an excellent visual outcome.

Conclusion

Colchicine treatment may have had a role in the pathogenesis of this rare case.
Literature
2.
go back to reference Tuft SJ, Coster DJ, Buckley RJ (1994) Acute corneal hydrops in keratoconus. Ophthalmology 101:1738–1744CrossRefPubMed Tuft SJ, Coster DJ, Buckley RJ (1994) Acute corneal hydrops in keratoconus. Ophthalmology 101:1738–1744CrossRefPubMed
3.
go back to reference Sharma N, Maharana PK, Jhanji V, Vishal J (2012) Management of acute corneal hydrops in ectatic corneal disorders. Curr Opin Ophthalmol 23:317–323CrossRefPubMed Sharma N, Maharana PK, Jhanji V, Vishal J (2012) Management of acute corneal hydrops in ectatic corneal disorders. Curr Opin Ophthalmol 23:317–323CrossRefPubMed
4.
go back to reference Tuft SJ, Zabel SJ, Gregory WM (1994) Prognostic factors for the progression of keratoconus. Ophthalmology 101:439–447CrossRefPubMed Tuft SJ, Zabel SJ, Gregory WM (1994) Prognostic factors for the progression of keratoconus. Ophthalmology 101:439–447CrossRefPubMed
5.
go back to reference Gül A (2014) Treatment of familial mediterranean fever: colchicine and beyond. IMAJ 16:281–284PubMed Gül A (2014) Treatment of familial mediterranean fever: colchicine and beyond. IMAJ 16:281–284PubMed
6.
go back to reference Buschke W, Friedenwald JS, Fleischmann W (1943) Studies on the mitotic activity of the corneal epithelium. Methods. The effects of colchicine, ether cocaine and ephedrine. Bull Johns Hopkins Hosp 73:143–167 Buschke W, Friedenwald JS, Fleischmann W (1943) Studies on the mitotic activity of the corneal epithelium. Methods. The effects of colchicine, ether cocaine and ephedrine. Bull Johns Hopkins Hosp 73:143–167
7.
go back to reference Wilson SE, Mohan RR, Mohan RR (2001) The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 20(5):625–637CrossRefPubMed Wilson SE, Mohan RR, Mohan RR (2001) The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 20(5):625–637CrossRefPubMed
8.
go back to reference Sukeishi A, Isami K, Hiyama H et al (2017) Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages. Mol Pain 13:17448069CrossRef Sukeishi A, Isami K, Hiyama H et al (2017) Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages. Mol Pain 13:17448069CrossRef
9.
go back to reference Leibovitch I, Alster Y, Scherrmann JM et al (2003) Colchicine in tear fluid of treated patients with familial mediterranean fever. Cornea 22(3):191–193CrossRefPubMed Leibovitch I, Alster Y, Scherrmann JM et al (2003) Colchicine in tear fluid of treated patients with familial mediterranean fever. Cornea 22(3):191–193CrossRefPubMed
10.
go back to reference Lahoud S, Brownstein S, Laflmme MY (1987) Keratoconus with spontaneous perforation of the cornea. Can J Ophthalmol 22:230–233PubMed Lahoud S, Brownstein S, Laflmme MY (1987) Keratoconus with spontaneous perforation of the cornea. Can J Ophthalmol 22:230–233PubMed
11.
go back to reference Ingraham HJ, Donnenfeld ED, Perry HD (1991) Keratoconus with spontaneous perforation of the Cornea. Am J Ophthalmol 109(12):1651–1652 Ingraham HJ, Donnenfeld ED, Perry HD (1991) Keratoconus with spontaneous perforation of the Cornea. Am J Ophthalmol 109(12):1651–1652
12.
go back to reference Nicoli C, Wainsztein R, Trotta LP (1999) Corneal topography of spontaneous perforation of acute hydrops in keratoconus. J Cataract Refract Surg 25(6):871–872CrossRefPubMed Nicoli C, Wainsztein R, Trotta LP (1999) Corneal topography of spontaneous perforation of acute hydrops in keratoconus. J Cataract Refract Surg 25(6):871–872CrossRefPubMed
13.
go back to reference McMonnies CW (2014) Mechanisms for acute corneal hydrops and perforation. Eye & Contact Lens: Science & Clinical Practice 40(4):257–264CrossRef McMonnies CW (2014) Mechanisms for acute corneal hydrops and perforation. Eye & Contact Lens: Science & Clinical Practice 40(4):257–264CrossRef
14.
go back to reference Gupta C, Tanaka TS, Elner VM et al (2015) Acute hydrops with corneal perforation in post-LASIK ectasia. Cornea 34(1):99–100CrossRefPubMed Gupta C, Tanaka TS, Elner VM et al (2015) Acute hydrops with corneal perforation in post-LASIK ectasia. Cornea 34(1):99–100CrossRefPubMed
15.
go back to reference Chen CL, Tai MC, Chen JT et al (2015) Acute corneal hydrops with perforation after LASIK-associated keratectasia. Clin Exp Ophthalmol 35(1):62–65CrossRef Chen CL, Tai MC, Chen JT et al (2015) Acute corneal hydrops with perforation after LASIK-associated keratectasia. Clin Exp Ophthalmol 35(1):62–65CrossRef
16.
go back to reference Toriyama K, Inoue T, Suzuki T et al (2013) Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. Cornea 32(6):839–841CrossRefPubMed Toriyama K, Inoue T, Suzuki T et al (2013) Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. Cornea 32(6):839–841CrossRefPubMed
17.
go back to reference Dantas PE, Nishiwaki-Dantas MC (2004) Spontaneous bilateral corneal perforation of acute hydrops in keratoconus. Eye Contact Lens 30(1):40–41CrossRefPubMed Dantas PE, Nishiwaki-Dantas MC (2004) Spontaneous bilateral corneal perforation of acute hydrops in keratoconus. Eye Contact Lens 30(1):40–41CrossRefPubMed
18.
go back to reference Lam FC, Bhatt PR, Ramaesh K (2011) Spontaneous perforation of the cornea in mild keratoconus. Cornea 30(1):103–104CrossRefPubMed Lam FC, Bhatt PR, Ramaesh K (2011) Spontaneous perforation of the cornea in mild keratoconus. Cornea 30(1):103–104CrossRefPubMed
19.
go back to reference Mostafavi D, Chu DS (2010) Two cases of keratoconus associated with spontaneous corneal perforation. Cornea 29(7):825–827CrossRefPubMed Mostafavi D, Chu DS (2010) Two cases of keratoconus associated with spontaneous corneal perforation. Cornea 29(7):825–827CrossRefPubMed
Metadata
Title
Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever
Authors
Assaf Hilely
Guy Kleinmann
Publication date
01-06-2019
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 6/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-018-0924-0

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