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International Ophthalmology

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01-04-2019 | Original Paper

Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid

Authors: Fatih Yenihayat, Berna Özkan, Murat Kasap, V. Levent Karabaş, Nil Güzel, Gürler Akpınar, Dilara Pirhan

Published in: International Ophthalmology | Issue 4/2019

Abstract

Purpose

To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples.

Methods

In this prospective case–control study, 11 eyes of 11 patients with DME and subretinal fluid, 11 eyes of 11 patients with DME without subretinal fluid, and 14 eyes of 14 patients who had undergone vitreoretinal surgery for the epiretinal membrane or a macular hole (control group) were evaluated. The blood glycated hemoglobin (HbA1c) level, vitreous vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) levels were determined.

Results

The vitreous VEGF level of patients in DME groups was significantly higher than the control group (p < 0.001) without significant difference between DME patients with and without subretinal fluid (p = 0.796). The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019). The blood HbA1c level was significantly higher in DME group with subretinal fluid than those without subretinal fluid (8.7 ± 1.32 and 7.1 ± 1.13%, respectively, p = 0.010). The only significant correlation was between vitreous VEGF level and blood HbA1c level in DME patients without subretinal fluid (r = 0.813, p = 0.002).

Conclusions

IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.

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Title: Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid
Authors: Fatih Yenihayat
Berna Özkan
Murat Kasap
V. Levent Karabaş
Nil Güzel
Gürler Akpınar
Dilara Pirhan
Publication date: 01-04-2019
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 4/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0874-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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