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International Ophthalmology
Published in: International Ophthalmology 10/2019

01-10-2019 | Diabetic Retinopathy | Original Paper

Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Authors: Ankita, Jana Stefanickova, Sandeep Saxena, Dwividendra K. Nim, Kaleem Ahmad, Abbas A. Mahdi, Apjit Kaur, Shashi K. Bhasker, Jela Valaskova, Peter Kruzliak

Published in: International Ophthalmology | Issue 10/2019

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Abstract

Purpose

To study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR).

Methods

This is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c < 7, n = 26) and group 2 (HbA1c > 7, n = 37). Data were analyzed statistically.

Results

Mean ionic calcium levels in group 1 and group 2 were 1.131 ± 0.073 mmol/dL and 1.170 ± 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p = 0.01) in group 2 cases.

Conclusion

Increased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c > 7 in DR.
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Metadata
Title
Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
Authors
Ankita
Jana Stefanickova
Sandeep Saxena
Dwividendra K. Nim
Kaleem Ahmad
Abbas A. Mahdi
Apjit Kaur
Shashi K. Bhasker
Jela Valaskova
Peter Kruzliak
Publication date
01-10-2019
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 10/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-018-01063-8

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