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International Ophthalmology

Published in:

01-01-2019 | Original Paper

Circumpapillary microperimetry to detect glaucoma: a pilot study for sector-based comparison to circumpapillary retinal nerve fiber layer measurement

Authors: Yoshiyuki Kita, Gábor Hollό, Tsunehiro Saito, Akiko Murai, Ritsuko Kita, Akito Hirakata

Published in: International Ophthalmology | Issue 1/2019

Abstract

Purpose

To evaluate and compare the diagnostic performance of circumpapillary microperimetry (MP) sensitivity and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measured with optical coherence tomography (OCT) for detection of early to moderate open-angle glaucoma.

Methods

Eleven eyes (11 patients) with early or moderate open-angle glaucoma and seven normal eyes (7 subjects) underwent MP (MP-3 microperimeter, NIDEK, Japan) and cpRNFLT measurement (RS-3000 Advance OCT, NIDEK, Japan) using an identical circumpapillary circle and similar measurement sectors. The structure–function relationship and the area under the receiver-operating characteristics curve (AUROC) were investigated for each sector, respectively.

Results

Significant differences (P < 0.05) between glaucoma and normal eyes were found for five of the 12 OCT sectors and seven of the 24 MP sectors. High correlation between cpRNFLT and MP sensitivity was found in the inferotemporal area (OCT sector 5) and superotemporal area (OCT sector 1) (r = 0.818, P < 0.001, and r = 0.796, P < 0.001, respectively). The AUROC values in these sectors ranged 0.890–1.000 for cpRNFLT and 0.825–0.981 for MP sensitivity. Overall, the AUROC ranged 0.506–1.000 for sector cpRNFLT and 0.591–0.981 for sector MP sensitivity.

Conclusions

In this pilot study, circumpapillary MP sensitivity and cpRNFLT showed similar diagnostic power. The structure–function relationship was strong for the superotemporal and inferotemporal circumpapillary areas. Our results suggest that circumpapillary MP represents a new aspect of microperimetry in glaucoma. Further studies on larger populations are necessary to clarify whether the current results are confirmed in clinical practice.

Ooto S, Suzuki M, Vongkulsiri S, Sato T, Spaide RF (2015) Multimodal visual function testing in eyes with nonexudative age-related macular degeneration. Retina 35:1726–1734CrossRefPubMed

Dal Vecchio M, Lavia C, Nassisi M, Grignolo FM, Fea AM (2016) Microperimetric assessment after epiretinal membrane surgery: 4-year follow-up. J Ophthalmol. https://doi.org/10.1155/2016/7030791 CrossRef

Cennamo G, Vecchio EC, Finelli M, Velotti N, de Crecchio G (2015) Evaluation of ischemic diabetic maculopathy with fourier-domain optical coherence tomography and microperimetry. Can J Ophthalmol 50:44–48CrossRefPubMed

Kim YH, Yun C, Kim JT, Kim SW, Oh J, Huh K (2014) The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema. Br J Ophthalmol 98:1618–1628CrossRefPubMed

Battu R, Khanna A, Hegde B, Berendschot TT, Grover S, Schouten JS (2015) Correlation of structure and function of the macula inpatients with retinitis pigmentosa. Eye 29:699–702CrossRef

Igarashi N, Matsuura M, Hashimoto Y, Hirasawa K, Murata H, Inoue T, Obata R, Aihara M, Asaoka R (2016) Assessing visual fields in patients with retinitis pigmentosa using a novel microperimeter with eye tracking: the MP-3. PLoS ONE. https://doi.org/10.1371/journal.pone.0166666 CrossRefPubMedPubMedCentral

Wu Z, Ayton LN, Luu CD, Guymer RH (2014) Relationship between retinal microstructures on optical coherence tomography and microperimetry in age-related macular degeneration. Ophthalmology 121:1445–1452CrossRefPubMed

Hirooka K, Misaki K, Nitta E, Ukegawa K, Sato S, Tsujikawa A (2016) Comparison of macular integrity assessment (MAIA™), MP-3, and Humphrey field analyzer in the evaluation of the relationship between the structure and function of the macula. PLoS ONE. https://doi.org/10.1371/journal.pone.0151000 CrossRefPubMedPubMedCentral

Sato S, Hirooka K, Baba T, Tenkumo K, Nitta E, Shiraga F (2013) Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry. Investig Ophthalmol Vis Sci 54:3046–3051CrossRef

10.

Rao HL, Januwada M, Hussain RS, Pillutla LN, Begum VU, Chaitanya A, Senthil S, Garudadri CS (2015) Comparing the structure–function relationship at the macula with standard automated perimetry and microperimetry. Investig Ophthalmol Vis Sci 56:8063–8068CrossRef

11.

Rao HL, Hussain RS, Januwada M, Pillutla LN, Begum VU, Chaitanya A, Senthil S, Garudadri CS (2016) Structural and functional assessment of macula to diagnose glaucoma. Eye 31:593–600CrossRefPubMedPubMedCentral

12.

Kita Y, Holló G, Kita R, Horie D, Inoue M, Hirakata A (2015) Differences of intrasession reproducibility of circumpapillary total retinal thickness and circumpapillary retinal nerve fiber layer thickness measurements made with the RS-3000 optical coherence tomograph. PLoS ONE 10(12):e0144721. https://doi.org/10.1371/journal.pone.0144721 CrossRefPubMedPubMedCentral

13.

Kita Y, Soutome N, Horie D, Kita R, Holló G (2017) Circumpapillary ganglion cell complex thickness to diagnose glaucoma: a pilot study. Indian J Ophthalmol 65:41–47CrossRefPubMedPubMedCentral

14.

Lee WJ, Na KI, Kim YK, Jeoung JW, Park KH (2017) Diagnostic ability of wide-field retinal nerve fiber layer maps using swept-source optical coherence tomography for detection of preperimetric and early perimetric glaucoma. J Glaucoma 26:577–585CrossRefPubMed

15.

Chen HY, Wang TH, Lee YM, Hung TJ (2005) Retinal nerve fiber layer thickness measured by optical coherence tomography and its correlation with visual field defects in early glaucoma. J Formos Med Assoc 104:927–934PubMed

Title: Circumpapillary microperimetry to detect glaucoma: a pilot study for sector-based comparison to circumpapillary retinal nerve fiber layer measurement
Authors: Yoshiyuki Kita
Gábor Hollό
Tsunehiro Saito
Akiko Murai
Ritsuko Kita
Akito Hirakata
Publication date: 01-01-2019
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0796-8

At a glance: The STEP trials

Springer Medicine

Circumpapillary microperimetry to detect glaucoma: a pilot study for sector-based comparison to circumpapillary retinal nerve fiber layer measurement

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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