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Published in: International Ophthalmology 6/2018

01-12-2018 | Case Report

Bilateral acute angle closure glaucoma and myopic shift by topiramate-induced ciliochoroidal effusion: case report and literature review

Authors: Yu-Wen Lan, Jui-Wen Hsieh

Published in: International Ophthalmology | Issue 6/2018

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Abstract

Purpose

To report two cases of ciliochoroidal effusion after the usage of topiramate.

Cases

Two middle-aged women experienced sudden onset of acute glaucoma and acquired myopia after taking topiramate. Ultrasound biomicroscopy demonstrated bilateral ciliochoroidal effusion and angle closure. The A-scan ultrasonography revealed shallow anterior chamber and thick lens. After the treatment and drug withdrawal, intraocular pressure, refractive status and angle anatomy returned to normal and there was resolution of ciliochoroidal effusion. During the clinical course, the anterior chamber depth (ACD) increased from 2.02 to 3.30 mm (1.28 mm of changes) OD and from 1.94 to 3.36 mm (1.42 mm of changes) OS. The lens thickness (LT) became thinner from 4.53 to 4.31 mm (0.22 mm of changes) OD and from 4.59 to 4.30 mm (0.29 mm of changes) OS in the first case. In the second case, the ACD increased from 2.33 to 3.07 mm (0.74 mm of changes) OD and from 2.30 to 3.05 mm (0.75 mm of changes) OS. The LT became thinner from 4.42 to 4.27 mm (0.15 mm of changes) OD and from 4.38 to 4.26 mm (0.12 mm of changes) OS. The forward displacement of the lens–iris diaphragm contributed more to the shallowness of the anterior chamber than the thickening of the lens itself (only accounting for 20%).

Conclusion

Topiramate-induced bilateral acute angle closure glaucoma and myopic shift was due to ciliochoroidal effusion which resulted in thicker lens and shallow anterior chamber. The later was mainly due to anterior displacement of the lens–iris diaphragm.
Literature
3.
go back to reference Nongpiur ME, Ku JY, Aung T (2011) Angle closure glaucoma: a mechanistic review. Curr Opin Ophthalmol 22:96–101CrossRef Nongpiur ME, Ku JY, Aung T (2011) Angle closure glaucoma: a mechanistic review. Curr Opin Ophthalmol 22:96–101CrossRef
5.
go back to reference Van Herick W, Shaffer RN, Schwartz A (1969) Estimation of width of angle of anterior chamber. Incidence and significance of the narrow angle. Am J Ophthalmol 68:626–629CrossRef Van Herick W, Shaffer RN, Schwartz A (1969) Estimation of width of angle of anterior chamber. Incidence and significance of the narrow angle. Am J Ophthalmol 68:626–629CrossRef
6.
go back to reference Lowe RF (1961) Angle-closure glaucoma: acute and subacute attacks: clinical types. Trans Ophthalmol Soc Aust 21:65 Lowe RF (1961) Angle-closure glaucoma: acute and subacute attacks: clinical types. Trans Ophthalmol Soc Aust 21:65
7.
go back to reference Hillman JS (1979) Acute closed-angle glaucoma: an investigation into the effect of delay in treatment. Br J Ophthalmol 63:817–821CrossRef Hillman JS (1979) Acute closed-angle glaucoma: an investigation into the effect of delay in treatment. Br J Ophthalmol 63:817–821CrossRef
8.
go back to reference Wojciechowski R, Congdon N, Anninger W, Teo Broman A (2003) Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos. Ophthalmology 110:365–375CrossRef Wojciechowski R, Congdon N, Anninger W, Teo Broman A (2003) Age, gender, biometry, refractive error, and the anterior chamber angle among Alaskan Eskimos. Ophthalmology 110:365–375CrossRef
9.
go back to reference Lyseng-Williamson KA, Yang LP (2007) Topiramate: a review of its use in the treatment of epilepsy. Drugs 67:2231–2256CrossRef Lyseng-Williamson KA, Yang LP (2007) Topiramate: a review of its use in the treatment of epilepsy. Drugs 67:2231–2256CrossRef
11.
go back to reference Mula M, Cavanna AE, Monaco F (2006) Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatr Dis Treat 2:475–488CrossRef Mula M, Cavanna AE, Monaco F (2006) Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatr Dis Treat 2:475–488CrossRef
14.
go back to reference Bray GA, Hollander P, Klein S, Kushner R, Levy B, Fitchet M, Perry BH (2003) A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res 11:722–733. doi:10.1038/oby.2003.102 CrossRefPubMed Bray GA, Hollander P, Klein S, Kushner R, Levy B, Fitchet M, Perry BH (2003) A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res 11:722–733. doi:10.​1038/​oby.​2003.​102 CrossRefPubMed
15.
go back to reference Schear NJ, Rowan AJ, Wiener JA, Haug SJ, Mindel JS (1990) Drug-induced myopia: a transient side effect of topiramate. Epilepsia 31:643 Schear NJ, Rowan AJ, Wiener JA, Haug SJ, Mindel JS (1990) Drug-induced myopia: a transient side effect of topiramate. Epilepsia 31:643
16.
go back to reference Gubbay SS (1998) The occurrence of drug-induced myopia as a transient side effect of topiramate. Epilepsia 39:451CrossRef Gubbay SS (1998) The occurrence of drug-induced myopia as a transient side effect of topiramate. Epilepsia 39:451CrossRef
17.
go back to reference Banta JT, Hoffman K, Budenz DL, Ceballos E, Greenfield DS (2001) Presumed topiramate-induced bilateral acute angle-closure glaucoma. Am J Ophthalmol 132:112–114CrossRef Banta JT, Hoffman K, Budenz DL, Ceballos E, Greenfield DS (2001) Presumed topiramate-induced bilateral acute angle-closure glaucoma. Am J Ophthalmol 132:112–114CrossRef
19.
go back to reference Hilton EJ, Hosking SL, Betts T (2004) The effect of antiepileptic drugs on visual performance. Seizure 13:113–128CrossRef Hilton EJ, Hosking SL, Betts T (2004) The effect of antiepileptic drugs on visual performance. Seizure 13:113–128CrossRef
22.
go back to reference Foroozan R, Buono LM (2003) Foggy visual field defect. Surv Ophthalmol 48:447–451CrossRef Foroozan R, Buono LM (2003) Foggy visual field defect. Surv Ophthalmol 48:447–451CrossRef
23.
go back to reference Czyz CN, Clark CM, Justice JD, Pokabla MJ, Weber PA (2014) Delayed topiramate-induced bilateral angle-closure glaucoma. J Glaucoma 23:577–578CrossRef Czyz CN, Clark CM, Justice JD, Pokabla MJ, Weber PA (2014) Delayed topiramate-induced bilateral angle-closure glaucoma. J Glaucoma 23:577–578CrossRef
24.
go back to reference Hook SR, Holladay JT, Prager TC, Goosey JD (1986) Transient myopia induced by sulfonamides. Am J Ophthalmol 101:495–496CrossRef Hook SR, Holladay JT, Prager TC, Goosey JD (1986) Transient myopia induced by sulfonamides. Am J Ophthalmol 101:495–496CrossRef
25.
go back to reference Panday VA, Rhee DJ (2007) Review of sulfonamide-induced acute myopia and acute bilateral angle-closure glaucoma. Compr Ophthalmol Update 8:271–276PubMed Panday VA, Rhee DJ (2007) Review of sulfonamide-induced acute myopia and acute bilateral angle-closure glaucoma. Compr Ophthalmol Update 8:271–276PubMed
26.
go back to reference Fraunfelder FT, Fraunfelder FW, Randall JA (2001) Drug-induced ocular side effects, 5th edn. Butterworth-Heinemann, Oxford Fraunfelder FT, Fraunfelder FW, Randall JA (2001) Drug-induced ocular side effects, 5th edn. Butterworth-Heinemann, Oxford
27.
go back to reference Ikeda N, Ikeda T, Nagata M, Mimura O (2002) Ciliochoroidal effusion syndrome induced by sulfa derivatives. Arch Ophthalmol 120:1775CrossRef Ikeda N, Ikeda T, Nagata M, Mimura O (2002) Ciliochoroidal effusion syndrome induced by sulfa derivatives. Arch Ophthalmol 120:1775CrossRef
28.
go back to reference Medeiros FA, Zhang XY, Bernd AS, Weinreb RN (2003) Angle-closure glaucoma associated with ciliary body detachment in patients using topiramate. Arch Ophthalmol 121:282–285CrossRef Medeiros FA, Zhang XY, Bernd AS, Weinreb RN (2003) Angle-closure glaucoma associated with ciliary body detachment in patients using topiramate. Arch Ophthalmol 121:282–285CrossRef
29.
go back to reference Craig JE, Ong TJ, Louis DL, Wells JM (2004) Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma. Am J Ophthalmol 137:193–195CrossRef Craig JE, Ong TJ, Louis DL, Wells JM (2004) Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma. Am J Ophthalmol 137:193–195CrossRef
31.
go back to reference Kimura R, Kasai M, Shoji K, Kanno C (1983) Swollen ciliary processes as an initial symptom in Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol 95:402–403CrossRef Kimura R, Kasai M, Shoji K, Kanno C (1983) Swollen ciliary processes as an initial symptom in Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol 95:402–403CrossRef
33.
go back to reference Tanaka S, Chuman Y, Akaike K, Doi W (2011) A case of topiramate-induced angle closure glaucoma. Nihon Shinkei Seishin Yakurigaku Zasshi 31:131–133PubMed Tanaka S, Chuman Y, Akaike K, Doi W (2011) A case of topiramate-induced angle closure glaucoma. Nihon Shinkei Seishin Yakurigaku Zasshi 31:131–133PubMed
37.
go back to reference Viet Tran H, Ravinet E, Schnyder C, Reichhart M, Guex-Crosier Y (2006) Blood-brain barrier disruption associated with topiramate-induced angle-closure glaucoma of acute onset. Klin Monbl Augenheilkd 223:425–427. doi:10.1055/s-2006-926600 CrossRefPubMed Viet Tran H, Ravinet E, Schnyder C, Reichhart M, Guex-Crosier Y (2006) Blood-brain barrier disruption associated with topiramate-induced angle-closure glaucoma of acute onset. Klin Monbl Augenheilkd 223:425–427. doi:10.​1055/​s-2006-926600 CrossRefPubMed
39.
Metadata
Title
Bilateral acute angle closure glaucoma and myopic shift by topiramate-induced ciliochoroidal effusion: case report and literature review
Authors
Yu-Wen Lan
Jui-Wen Hsieh
Publication date
01-12-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 6/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0740-y

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