Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 5/2018

01-10-2018 | Original Paper

Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract

Authors: Kemal Tekin, Yasemin Ozdamar Erol, Merve Inanc, Mustafa Fevzi Sargon, Cigdem Ulku Can, Sibel Polat, Pelin Yilmazbas

Published in: International Ophthalmology | Issue 5/2018

Login to get access

Abstract

Purpose

To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.

Methods

This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).

Results

Some significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.

Conclusions

We identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts.
Literature
1.
Chan WH, Biswas S, Ashworth JL, Lyold IC (2012) Congenital and infantile cataract: aetiology and management. Eur J Pediatr 171:625–630CrossRefPubMed
2.
Prado RB, Silva VF, Schellini SA, Rodrigues AC (2016) Congenital and development cataract: axial length and keratometry study in Brazilian children. Arq Bras Ophthalmol 79:19–23
3.
Zetterström C, Lundvall A, Kugelberg M (2005) Cataracts in children. J Cataract Refract Surg 31:824–840CrossRefPubMed
4.
Vasavada AR, Nihalani BR (2006) Pediatric cataract surgery. Curr Opin Ophthalmol 17:54–61PubMed
5.
6.
7.
8.
Straatsma BR, Lightfoot DO, Barke RM, Horwitz J (1991) Lens capsule and epithelium in age-related cataract. Am J Ophthalmol 112:283–296CrossRefPubMed
9.
Joo CK, Lee EH, Kim JC, Kim YH, Lee JH, Kim JT, Chung KH, Kim J (1999) Degeneration and trans differentiation of human lens epithelial cells in nuclear and anterior polar cataracts. J Cataract Refract Surg 25:652–658CrossRefPubMed
10.
Charakidas A, Kalogeraki A, Tsilimbaris M, Koukoulomatis P, Brouzas D, Delides G (2005) Lens epithelial apoptosis and cell proliferation in human age-related cortical cataract. Eur J Ophthalmol 15:213–220CrossRefPubMed
11.
12.
Krag S, Andreassen TT (2003) Mechanical properties of the human lens capsule. Prog Retin Eye Res 22:749–767CrossRefPubMed
13.
Parmigiani CM, McAvoy JW (1991) The roles of laminin and fibronectin in the development of the lens capsule. Curr Eye Res 10:501–511CrossRefPubMed
14.
15.
Andjelic S, Drašlar K, Hvala A, Lopic N, Strancar J, Hawlina M (2016) Anterior lens epithelial cells attachment to the basal lamina. Acta Ophthalmol 94:183–188CrossRef
16.
Meyer LM, Wegener AR, Holz FG, Kronschläger M, Bergmanson JP, Soderberg PG (2014) Ultrastructure of UVR-B-induced cataract and repair visualized with electron microscopy. Acta Ophthalmol 92:635–643CrossRefPubMed
17.
Synder A, Omulecka A, Ratynska M, Omulecki W (2002) A study of human lens epithelial cells by light and electron microscopy and by immunohistochemistry in different types of cataracts. Klin Oczna 104:369–373PubMed
18.
Bleckmann H, Khodadadyan C, Schnoy N (1989) Light and electron microscopy of the human, anterior cataract capsule. Fortschr Ophthalmol 86:556–560PubMed
19.
Sargon MF, Celik HH, Orhan M (1997) Electron microscopy of the senile changes in lens epithelium. Okajimas Folia Anat Jpn 74:75–79CrossRefPubMed
20.
Vasavada AR, Cherian M, Yadav S, Rawal UM (1991) Lens epithelial cell density and histomorphological study in cataractous lenses. J Cataract Refract Surg 17:798–804CrossRefPubMed
21.
Andjelic S, Drašlar K, Hvala A, Hawlina M (2016) Anterior lens epithelium in intumescent white cataracts- scanning and transmission electron microscopy study. Graefes Arch Clin Exp Ophthalmol 254:269–276CrossRefPubMed
22.
Andjelic S, Draslar K, Hvala A, Hawlina M (2017) Anterior lens epithelium in cataract patients with retinitis pigmentosa—scanning and transmission electron microscopy study. Acta Ophthalmol 95:212–220CrossRef
23.
24.
Hammond BR, Johnson BA, George ER (2014) Oxidative photodegradation of ocular tissues: beneficial effects of filtering and exogenous antioxidants. Exp Eye Res 129:135–150CrossRefPubMed
25.
Cheng HM, Fagerholm P, Chylack LT Jr. (1983) Response of the lens to oxidative-osmotic stress. Exp Eye Res 37:11–21CrossRefPubMed
26.
Nita M, Grzybowski A (2016) The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev 2016:3164734CrossRefPubMedCentralPubMed
27.
28.
Khurana AK (2007) Diseases of the lens, comprehensive ophthalmology, 4th edn. New Age International (P) Ltd, New Delhi, pp 167–204
29.
Haargard B, Wohlfahrt J, Fledelius HC, Rosenberg T, Melbye M (2004) A nationwide Danish study of 1027 cases of congenital/infantile cataracts: etiological and clinical classifications. Ophthalmology 111:2292–2298CrossRef
30.
31.
Prakalapakom SG, Rasmussen SA, Lambert SR, Honein MA, National Birth Defects Prevention Study (2010) Assessment of risk factors for infantile cataracts using a case-control study: National Birth Defects Prevention Study, 2000–2004. Ophthalmology 117:1500–1505CrossRef
32.
Lloyd IC, Goss-Sampson M, Jeffrey BG, Kriss A, Russell-Eggitt I, Taylor D (1992) Neonatal cataract: aetiology, pathogenesis and management. Eye (Lond) 6:184–196CrossRef
33.
Stunf S, Hvala A, Vidovič Valentinčič N, Kraut A, Hawlina M (2012) Ultrastructure of the anterior lens capsule and epithelium in cataracts associated with uveitis. Ophthalmic Res 48:12–21CrossRefPubMed
Metadata
Title
Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract
Authors
Kemal Tekin
Yasemin Ozdamar Erol
Merve Inanc
Mustafa Fevzi Sargon
Cigdem Ulku Can
Sibel Polat
Pelin Yilmazbas
Publication date
01-10-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0713-1

Other articles of this Issue 5/2018

International Ophthalmology 5/2018 Go to the issue

Original Paper

Effect of iris registration on outcomes of FEMTOLASIK for myopia and myopic astigmatism

Original Paper

Upregulated IRAK1 and IRAK4 promoting the production of IFN-γ and IL-17 in Behcet’s disease

Case Report

Turning a blind eye: HTLV-1-associated uveitis in Indigenous adults from Central Australia

Original Paper

A novel and cheap method to correlate subjective and objective visual acuity by using the optokinetic response

Case Report

Reversal of retinal pigment epithelial detachment after cessation of topical travoprost therapy

Review

Pediatric keratoconus: a review of the literature