Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 5/2018

01-10-2018 | Case Report

Bilateral macular infarction after gemcitabine and carboplatin chemotherapy

Authors: Umesh Chandra Behera, Rohit R. Modi, Jenil Sheth, Arshi Singh

Published in: International Ophthalmology | Issue 5/2018

Login to get access

Abstract

Purpose

To report a case of macular infarction after doublet chemotherapy with gemcitabine and carboplatin.

Methods

A middle-aged lady presenting with bilateral macular infarction post-chemotherapy for metastatic cervical malignancy was investigated for thromboembolic risks and treated.

Results

The macular perfusion and edema improved with control of hypertension and treatment with pentoxifylline. Visual improvement was satisfactory, and the possible associated risk such as hypertension was noted.

Conclusion

This case underscores the need for active screening of patients on chemotherapy with gemcitabine and carboplatin for retinal vascular occlusive changes when hypertension is associated.
Appendix
Available only for authorised users
Literature
1.
Cavdar C, Toprak O, Oztop I, Secil M, Cokmert S, Camsari T (2007) Bilateral renal infarction in a patient with lung carcinoma treated with cisplatin and gemcitabine. Ren Fail 29:923–925CrossRefPubMed
2.
Banach MJ, Williams GA (2000) Purtscher retinopathy and necrotizing vasculitis with gemcitabine therapy. Arch Ophthalmol 118(5):726–727CrossRefPubMed
3.
Sheyman AT, Wald KJ, Pahk PJ, Freund KB (2014) Gemcitabine associated retinopathy and nephropathy. Retin Cases Brief Rep 8(2):107–109CrossRefPubMed
4.
5.
Shahab N, Haider S, Doll DC (2006) Vascular toxicity of antineoplastic agents. Semin Oncol 33:121–138CrossRefPubMed
6.
O’Brien ME, Tonge K, Blake P, Moskovic E, Wiltshaw E (1992) Blindness associated with high-dose carboplatin. Lancet 339(8792):558CrossRefPubMed
7.
Tran TH, Desauw C, Rose C (2009) Gemcitabine-induced retinopathy in a diabetic patient. Acta Ophthalmol 87(1):114–115CrossRefPubMed
8.
Agustoni F, Platania M, Vitali M et al (2014) Emerging toxicities in the treatment of non-small cell lung cancer: ocular disorders. Cancer Treat Rev 40(1):197–203CrossRefPubMed
Metadata
Title
Bilateral macular infarction after gemcitabine and carboplatin chemotherapy
Authors
Umesh Chandra Behera
Rohit R. Modi
Jenil Sheth
Arshi Singh
Publication date
01-10-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0698-9

Other articles of this Issue 5/2018

International Ophthalmology 5/2018 Go to the issue

Original Paper

Diabetes and pachymetry changes in pregnancy

Case Report

Interface Scopulariopsis gracilis fungal keratitis following Descemet’s stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft

Original Paper

Upregulated IRAK1 and IRAK4 promoting the production of IFN-γ and IL-17 in Behcet’s disease

Original Paper

A novel and cheap method to correlate subjective and objective visual acuity by using the optokinetic response

Original Paper

Comparison of cumulative dissipated energy delivered by active-fluidic pressure control phacoemulsification system versus gravity-fluidics

Original Paper

“What should I inject next?” Challenging treatment decisions in the multiple anti-VEGF: a review of publications exploring anti-VEGF switching for nAMD