Skip to main content
Top
Published in: International Ophthalmology 5/2018

01-10-2018 | Case Report

Turning a blind eye: HTLV-1-associated uveitis in Indigenous adults from Central Australia

Authors: Rusheng Chew, Timothy Henderson, Jaskirat Aujla, Eline Whist, Lloyd Einsiedel

Published in: International Ophthalmology | Issue 5/2018

Login to get access

Abstract

Purpose

We describe the first two cases of HTLV-1 associated uveitis to be associated with HTLV-1c subtype infection.

Methods

Case report.

Results

Uveitis was demonstrated in two Indigenous Australian men, both of whom had high HTLV-1c proviral loads in peripheral blood. Visual outcomes were poor in each case.

Conclusion

Clinicians should be aware of HTLV-1c infection as a cause of uveitis in Australia, and HTLV-1 serology should be included in the basic uveitis work-up in HTLV-1-endemic areas.
Literature
1.
go back to reference Northern Territory Department of Health and Families (2010) Central Australia regional plan 2010–2012. Northern Territory Government, Darwin Northern Territory Department of Health and Families (2010) Central Australia regional plan 2010–2012. Northern Territory Government, Darwin
2.
go back to reference Einsiedel L, Fernandes L, Joseph S (2013) Non-communicable diseases, infection and survival in a retrospective cohort of Indigenous and non-indigenous adults in Central Australia. BMJ Open 3:e003070CrossRefPubMedCentralPubMed Einsiedel L, Fernandes L, Joseph S (2013) Non-communicable diseases, infection and survival in a retrospective cohort of Indigenous and non-indigenous adults in Central Australia. BMJ Open 3:e003070CrossRefPubMedCentralPubMed
3.
go back to reference Australian Institute of Health and Welfare/Australian Bureau of Statistics. The health and welfare of Australia’s Aboriginal and Torres Strait Islander peoples. 2008 Commonwealth of Australia, Australian Bureau of Statistics catalogue number 4704.0, Canberra Australian Institute of Health and Welfare/Australian Bureau of Statistics. The health and welfare of Australia’s Aboriginal and Torres Strait Islander peoples. 2008 Commonwealth of Australia, Australian Bureau of Statistics catalogue number 4704.0, Canberra
4.
go back to reference Einsiedel L, Spelman T, Goeman E et al (2014) Clinical associations of Human T-lymphotropic virus type 1 in an Indigenous Australian population. PLOS Negl Trop Dis 8:e2643CrossRefPubMedCentralPubMed Einsiedel L, Spelman T, Goeman E et al (2014) Clinical associations of Human T-lymphotropic virus type 1 in an Indigenous Australian population. PLOS Negl Trop Dis 8:e2643CrossRefPubMedCentralPubMed
5.
go back to reference Martin F, Taylor GT, Jacobson S (2014) Inflammatory manifestations of HTLV-1 and their therapeutic options. Expert Rev Clin Immunol 10:1531–1546CrossRefPubMed Martin F, Taylor GT, Jacobson S (2014) Inflammatory manifestations of HTLV-1 and their therapeutic options. Expert Rev Clin Immunol 10:1531–1546CrossRefPubMed
6.
go back to reference Merle H, Smadja D, Le Hoang P et al (1996) Ocular manifestations in patients with HTLV-1 associated infection—a clinical study of 93 cases. Jpn J Ophthalmol 40:260–270PubMed Merle H, Smadja D, Le Hoang P et al (1996) Ocular manifestations in patients with HTLV-1 associated infection—a clinical study of 93 cases. Jpn J Ophthalmol 40:260–270PubMed
8.
go back to reference Murphy EL, Figueroa JP, Gibbs WN et al (1991) Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica: I demographic determinants. Am J Epidemiol 133:1114–1124CrossRefPubMed Murphy EL, Figueroa JP, Gibbs WN et al (1991) Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica: I demographic determinants. Am J Epidemiol 133:1114–1124CrossRefPubMed
10.
go back to reference Einsiedel L, Woodman RJ, Flynn M et al (2016) Human T-lymphotropic virus type 1 infection in an Indigenous Australian population: epidemiological insights from a hospital-based cohort study. BMC Public Health 16:787CrossRefPubMedCentralPubMed Einsiedel L, Woodman RJ, Flynn M et al (2016) Human T-lymphotropic virus type 1 infection in an Indigenous Australian population: epidemiological insights from a hospital-based cohort study. BMC Public Health 16:787CrossRefPubMedCentralPubMed
11.
go back to reference Einsiedel LJ, Pham H, Woodman RJ et al (2016) The prevalence and clinical associations of HTLV-1 infection in a remote Indigenous community. Med J Aust 205:305–309CrossRefPubMed Einsiedel LJ, Pham H, Woodman RJ et al (2016) The prevalence and clinical associations of HTLV-1 infection in a remote Indigenous community. Med J Aust 205:305–309CrossRefPubMed
12.
go back to reference Nagai M, Usuku K, Matsumoto W et al (1998) Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol 4:586–593CrossRefPubMed Nagai M, Usuku K, Matsumoto W et al (1998) Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol 4:586–593CrossRefPubMed
13.
go back to reference Einsiedel L, Fernandes L, Spelman T et al (2012) Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population. Clin Infect Dis 54:43–50CrossRefPubMed Einsiedel L, Fernandes L, Spelman T et al (2012) Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population. Clin Infect Dis 54:43–50CrossRefPubMed
14.
go back to reference Einsiedel L, Cassar O, Goeman E et al (2014) Higher human T-lymphotropic virus type 1 subtype C proviral loads are associated with bronchiectasis in Indigenous Australians: results of a case-control study. Open Forum Infect Dis 1:ofu023CrossRefPubMedCentralPubMed Einsiedel L, Cassar O, Goeman E et al (2014) Higher human T-lymphotropic virus type 1 subtype C proviral loads are associated with bronchiectasis in Indigenous Australians: results of a case-control study. Open Forum Infect Dis 1:ofu023CrossRefPubMedCentralPubMed
15.
16.
go back to reference Miyanaga M, Shimizu K, Kawaguchi T et al (2009) A clinical survey of uveitis in HTLV-I endemic region. OculImmunolInflamm 17:335 Miyanaga M, Shimizu K, Kawaguchi T et al (2009) A clinical survey of uveitis in HTLV-I endemic region. OculImmunolInflamm 17:335
17.
go back to reference Merle H, Cabre P, Olindo S et al (2002) Ocular lesions in 200 patients infected by the human T-cell lymphotropic virus type 1 in Martinique (French West Indies). Am J Ophthalmol 134:190–195CrossRefPubMed Merle H, Cabre P, Olindo S et al (2002) Ocular lesions in 200 patients infected by the human T-cell lymphotropic virus type 1 in Martinique (French West Indies). Am J Ophthalmol 134:190–195CrossRefPubMed
18.
go back to reference Pinheiro SR, Carneiro-Proietri AB, Lima-Martins MV et al (1996) HTLV-I/II seroprevalence in 55 Brazilian patients with idiopathic uveitis. Rev Soc Bras Med Trop 29:383–384CrossRefPubMed Pinheiro SR, Carneiro-Proietri AB, Lima-Martins MV et al (1996) HTLV-I/II seroprevalence in 55 Brazilian patients with idiopathic uveitis. Rev Soc Bras Med Trop 29:383–384CrossRefPubMed
20.
go back to reference Yoshimura K, Mochizuki M, Araki S et al (1993) Clinical and immunologic features of human T-cell lymphotropic virus type I uveitis. Am J Ophthalmol 116:156–163CrossRefPubMed Yoshimura K, Mochizuki M, Araki S et al (1993) Clinical and immunologic features of human T-cell lymphotropic virus type I uveitis. Am J Ophthalmol 116:156–163CrossRefPubMed
Metadata
Title
Turning a blind eye: HTLV-1-associated uveitis in Indigenous adults from Central Australia
Authors
Rusheng Chew
Timothy Henderson
Jaskirat Aujla
Eline Whist
Lloyd Einsiedel
Publication date
01-10-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0659-3

Other articles of this Issue 5/2018

International Ophthalmology 5/2018 Go to the issue