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International Ophthalmology
Published in: International Ophthalmology 4/2018

01-08-2018 | Original Paper

Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery

Authors: Selahattin Balsak, Ayhan Kaydu, Seyfettin Erdem, M. Fuat Alakus, Zeynep Gursel Ozkurt

Published in: International Ophthalmology | Issue 4/2018

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Abstract

Purpose

To compare the efficacy of the fixed combination of brimonidine–timolol (FCBT) and the fixed combination of brinzolamide–timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery.

Methods

A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5.

Results

No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05).

Conclusions

We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.
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Metadata
Title
Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery
Authors
Selahattin Balsak
Ayhan Kaydu
Seyfettin Erdem
M. Fuat Alakus
Zeynep Gursel Ozkurt
Publication date
01-08-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 4/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0626-z

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