Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 4/2018

01-08-2018 | Original Paper

Association between the 8-oxoguanine DNA glycosylase gene Ser326Cys polymorphism and age-related cataract: a systematic review and meta-analysis

Authors: Xiao-Cui Liu, Xiao-Hui Guo, Bing Chen, Zhao-Hui Li, Xiao-Fei Liu

Published in: International Ophthalmology | Issue 4/2018

Login to get access

Abstract

Purpose

To investigate the association between the 8-oxoguanine DNA glycosylase (OGG1) gene Ser326Cys (rs1052133) polymorphism and age-related cataract (ARC).

Methods

MEDLINE and EMBASE were searched to identify potential studies published before May 19, 2017, investigating the association between the OGG1 gene Ser326Cys polymorphism and ARC risk. The quality of eligible studies was assessed using the Newcastle–Ottawa Scale tool. The association between the OGG1 gene Ser326Cys polymorphism and ARC was analyzed using meta-analysis. Publication bias and sensitivity analyses were also performed.

Results

Six studies were included in this systematic review, and five of these studies with Hardy–Weinberg equilibrium were included in a meta-analysis. The sample size of the meta-analysis was 3716, including 1831 patients with cataract and 1885 controls. Odds ratios (ORs) were 0.67 (95% confidence interval (CI) 0.52–0.85), 0.90 (95% CI 0.54–1.51), 0.52 (95% CI 0.32–0.85) and 0.72 (95% CI 0.56–0.92) for recessive, dominant, additive and allele contrast models, respectively. Sensitivity analysis indicated that the results of the meta-analysis were robust. No publication bias was observed.

Conclusions

The OGG1 gene Ser326Cys polymorphism was associated with ARC risk.
Literature
1.
Khairallah M, Kahloun R, Bourne R, Limburg H, Flaxman SR, Jonas JB, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, White RA, Wong TY, ResnikoffS Taylor HR (2015) Number of people blind or visually impaired by cataract worldwide and in world regions, 1990–2010. Invest Ophthalmol Vis Sci 56:6762–6769CrossRefPubMed
2.
3.
Ottonello S, Foroni C, Carta A, Petrucco S, Maraini G (2000) Oxidative stress and age-related cataract. Ophthalmologica 214:78–85CrossRefPubMed
4.
5.
6.
Xu B, Kang L, Zhang G, Wu J, Zhu R, Yang M, Guan H (2015) The changes of 8-ohdg, hogg1, ape1 and pol beta in lenses of patients with age-related cataract. Curr Eye Res 40:378–385CrossRefPubMed
7.
Zhang Y, Zhang L, Zhang L, Bai J, Ge H, Liu P (2010) Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens. Mol Vis 16:1754–1763PubMedPubMedCentral
8.
Pendergrass W, Penn P, Possin D, Wolf N (2005) Accumulation of DNA, nuclear and mitochondrial debris, and ros at sites of age-related cortical cataract in mice. Invest Ophthalmol Vis Sci 46:4661–4670CrossRefPubMed
9.
Osnes-Ringen O, Azqueta AO, Moe MC, Zetterstrom C, Roger M, Nicolaissen B, Collins AR (2013) DNA damage in lens epithelium of cataract patients in vivo and ex vivo. Acta Ophthalmol 91:652–656CrossRefPubMed
10.
Storr SJ, Woolston CM, Martin SG (2012) Base excision repair, the redox environment and therapeutic implications. Curr Mol Pharmacol 5:88–101CrossRefPubMed
11.
12.
Wang Y, Li F, Zhang G, Kang L, Qin B, Guan H (2015) Altered DNA methylation and expression profiles of 8-oxoguanine DNA glycosylase 1 in lens tissue from age-related cataract patients. Curr Eye Res 40:815–821CrossRefPubMed
13.
Kohno T, Shinmura K, Tosaka M, Tani M, Kim SR, Sugimura H, Nohmi T, Kasai H, Yokota J (1998) Genetic polymorphisms and alternative splicing of the hogg1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 16:3219–3225CrossRefPubMed
14.
Karahalil B, Bohr VA, Wilson DM 3rd (2012) Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol 31:981–1005CrossRefPubMedPubMedCentral
15.
Zhang H, Zhong J, Bian Z, Fang X, Peng Y, Hu Y (2016) Association between polymorphisms of OGG1, EPHA2 and age-related cataract risk: a meta-analysis. BMC Ophthalmol 16:168CrossRefPubMedPubMedCentral
16.
Wu X, Lai W, Lin H, Liu Y (2017) Association of OGG1 and MTHFR polymorphisms with age-related cataract: a systematic review and meta-analysis. PLoS One 12:e0172092CrossRefPubMedPubMedCentral
17.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. Ann Intern Med 151:264–269, W64
18.
Song GG, Bae SC, Kim JH, Kim YH, Choi SJ, Ji JD, Lee YH (2013) Association between functional fc receptor-like 3 (fcrl3) -169 c/t polymorphism and susceptibility to seropositive rheumatoid arthritis in asians: a meta-analysis. Hum Immunol 74:1206–1213CrossRefPubMed
19.
Liu XC, Liu XF, Hu ZD, Li ZH (2015) Polymorphisms of DNA repair genes xpd (lys751gln) and xrcc1 (arg399gln), and the risk of age-related cataract: a meta-analysis. Curr Eye Res 40:676–682CrossRefPubMed
20.
Wells GA, Shea BJ, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2000) The Newcastle–Ottawa scale (NOS) for assessing the quality of non-randomized studies in meta-analysis
21.
22.
Zintzaras E, Ioannidis JP (2005) Hegesma: genome search meta-analysis and heterogeneity testing. Bioinformatics 21:3672–3673CrossRefPubMed
23.
Zhang Y, Zhang L, Song Z, Sun DL, Liu HR, Fu SB, Liu DR, Liu P (2012) Genetic polymorphisms in DNA repair genes ogg1, ape1, xrcc1, and xpd and the risk of age-related cataract. Ophthalmology 119:900–906CrossRefPubMed
24.
Jiang S, Hu N, Zhou J, Zhang J, Gao R, Hu J, Guan H (2013) Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. Age 35:2435–2444CrossRefPubMedPubMedCentral
25.
Gharib AF, Dabour SA, Etewa RL, Fouad RA (2014) Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians. Mol Vis 20:661–669PubMedPubMedCentral
26.
Wang C, Lai Q, Zhang S, Hu J (2015) Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. Int J Clin Exp Pathol 8:16036–16045PubMedPubMedCentral
27.
Zha X, Liang G, Zhang Y, Ma L, Zhu S, Zhao X (2016) The relationship of DNA repair gene XPD, XRCC1, OGG1, APE1, and WRN polymorphism with the risk of age-related cataract in Hani people from Mojiang region in Yunnan. Int J Clin Exp Med 9:8706–8712
28.
Wang S, Wang C, He J, Hou L (2015) Association between 8-oxoguanine DNA glycosylase-1 polymorphism and age-related cataract. Shanxi Med J 44:1639–1641
29.
Salanti G, Amountza G, Ntzani EE, Ioannidis JP (2005) Hardy–Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet 13:840–848CrossRefPubMed
30.
Peng Q, Lu Y, Lao X, Chen Z, Li R, Sui J, Qin X, Li S (2014) Association between ogg1 ser326cys and apex1 asp148glu polymorphisms and breast cancer risk: a meta-analysis. Diagn Pathol 9:108CrossRefPubMedPubMedCentral
31.
Ali K, Mahjabeen I, Sabir M, Mehmood H, Kayani MA (2015) OGG1 mutations and risk of female breast cancer: Meta-analysis and experimental data. Dis Markers 690878
32.
Zhou PT, Li B, Ji J, Wang MM, Gao CF (2015) A systematic review and meta-analysis of the association between ogg1 ser326cys polymorphism and cancers. Med Oncol 32:472PubMed
33.
Gokkusu C, Cakmakoglu B, Dasdemir S, Tulubas F, Elitok A, Tamer S, Seckin S, Umman B (2013) Association between genetic variants of DNA repair genes and coronary artery disease. Genet Test Mol Biomarkers 17:307–313CrossRefPubMed
34.
Roberts JE (2011) Ultraviolet radiation as a risk factor for cataract and macular degeneration. Eye Contact Lens 37:246–249CrossRefPubMed
35.
Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS, Abbey H, Emmett EA (1988) Effect of ultraviolet radiation on cataract formation. N Engl J Med 319:1429–1433CrossRefPubMed
36.
Chodick G, Bekiroglu N, Hauptmann M, Alexander BH, Freedman DM, Doody MM, Cheung LC, Simon SL, Weinstock RM, Bouville A, Sigurdson AJ (2008) Risk of cataract after exposure to low doses of ionizing radiation: a 20-year prospective cohort study among us radiologic technologists. Am J Epidemiol 168:620–631CrossRefPubMedPubMedCentral
37.
Jiang Q, Zhou C, Healey S, Chu W, Kouttab N, Bi Z, Wan Y (2006) UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells. Int J Mol Med 18:381–387PubMed
38.
Yao J, Liu Y, Wang X, Shen Y, Yuan S, Wan Y, Jiang Q (2009) UVB radiation induces human lens epithelial cell migration via NADPH oxidase-mediated generation of reactive oxygen species and up-regulation of matrix metalloproteinases. Int J Mol Med 24:153–159PubMed
39.
Kershaw RM, Hodges NJ (2012) Repair of oxidative DNA damage is delayed in the ser326cys polymorphic variant of the base excision repair protein ogg1. Mutagenesis 27:501–510CrossRefPubMed
Metadata
Title
Association between the 8-oxoguanine DNA glycosylase gene Ser326Cys polymorphism and age-related cataract: a systematic review and meta-analysis
Authors
Xiao-Cui Liu
Xiao-Hui Guo
Bing Chen
Zhao-Hui Li
Xiao-Fei Liu
Publication date
01-08-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 4/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0606-3

Other articles of this Issue 4/2018

International Ophthalmology 4/2018 Go to the issue

Original Paper

Intracorneal ring segment depth in keratoconus patients: a long-term follow-up study

Case Report

Crystalline retinopathy association with flupentixol intake

Original Paper

The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP

Original Paper

Comparison of visual acuity measurements via three different methods in preschool children: Lea symbols, crowded Lea symbols, Snellen E chart

Original Paper

Comparison of formulas and methods for high myopia patients requiring intraocular lens powers less than six diopters

Original Paper

Glaucoma awareness amongst glaucoma patients seeking a second opinion