Top

International Ophthalmology

Published in:

01-08-2018 | Original Paper

The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP

Authors: Suzan Guven Yilmaz, Cumali Degirmenci, Yunus Emre Karakoyun, Emil Yusifov, Halil Ates

Published in: International Ophthalmology | Issue 4/2018

Abstract

Purpose

To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma.

Methods

This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg. Group 1 (n = 18) received BTFC, group 2 (n = 14) received LTFC, and group 3 (n = 18) received TTFC. All patients were hospitalized, and IOP was monitored for 24-h (10:00, 14:00, 18:00, 22:00, 02:00, and 06:00). Mean diurnal IOP variation measurements were taken between 06:00 and 18:00, and mean nocturnal IOP variation measurements were taken between 22:00 and 02:00. Mean IOP and IOP variation in the three groups were compared.

Results

Mean 24-h IOP did not differ significantly between the three groups (group 1: 14.6 ± 2.9 mmHg; group 2: 14.1 ± 3.7 mmHg and group 3: 15.8 ± 2.0 mmHg; P > 0.05). Mean diurnal IOP variation was 4.6 ± 2.3 mmHg in group 1, 5.8 ± 2.4 mmHg in group 2, and 4.3 ± 1.7 mmHg in group 3, and mean nocturnal IOP variation was 3.2 ± 2.8 mmHg in group 1, 2.9 ± 1.9 mmHg in group 2, and 3.0 ± 1.6 mmHg group 3. There were not any significant differences in diurnal or nocturnal IOP variation between the three groups (P < 0.05).

Conclusion

All three fixed combinations effectively controlled IOP for 24-h and had a similar effect on diurnal and nocturnal IOP variations.

Rosenberg LF, Krupin T (1999) Primary open angle glaucoma. In: Yanoff M, Duker SJ (eds) Ophthalmology, 1st edn. Mosby, St. Louis, pp 130–157

The Advanced Glaucoma Intervention Study (AGIS): 7 (2000) The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol 130:429–440CrossRef

Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M; Early Manifest Glaucoma Trial Group (2002) Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch Ophthalmol 120:1268–1279CrossRef

Leskea MC, Heijl A, Hyman L, Bengtsson B, Komaroff E (2004) Factors for progression and glaucoma treatment: the early manifest glaucoma trial. Curr Opin Ophthalmol 15:102–106CrossRef

Nouri-Mahdavi K, Hoffman D, Coleman AL et al (2004) Predictive factors for glaucomatous visual field progression in the advanced glaucoma intervention study. Ophthalmology 111:1627–1635CrossRefPubMed

Kim SH, Lee EJ, Han JC, Sohn SW, Rhee T, Kee C (2016) The effect of diurnal fluctuation in intraocular pressure on the evaluation of risk factors of progression in normal tension glaucoma. PLoS ONE 11:e0164876CrossRefPubMedPubMedCentral

Caprioli J, Coleman AL (2008) Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study. Ophthalmology 115:1123–1129CrossRefPubMed

Vorwerk C, Thelen U, Buchholz P, Kimmich F (2008) Treatment of glaucoma patients with insufficient intraocular pressure control: a survey of German ophthalmologists in private practice. Curr Med Res Opin 24:1295–1301CrossRefPubMed

Maruyama Y, Ikeda Y, Mori K, Ueno M, Yoshikawa H, Kinoshita S (2015) Comparison between bimatoprost and latanoprost-timolol fixed combination for efficacy and safety after switching patients from latanoprost. Clin Ophthalmol 9:1429–1436CrossRefPubMedPubMedCentral

10.

Konstas AG, Bányai L, Blask KD et al (2004) Intraocular pressure and safety in glaucoma patients switching to latanoprost/timolol maleate fixed combination from mono- and adjunctive therapies. J Ocul Pharmacol Ther 20:375–382CrossRefPubMed

11.

Cheng JW, Cheng SW, Gao LD, Lu GC, Wei RL (2012) Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis. PLoS ONE. doi:10.1371/journal.pone.004507 CrossRefPubMedPubMedCentral

12.

Kass MA, Heuer DK, Higginbotham EJ et al (2002) The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 120:701–713CrossRefPubMed

13.

Tsai JC (2009) A comprehensive perspective on patient adherence to topical glaucoma therapy. Ophthalmology 116:30–36CrossRef

14.

Gray TA, Orton LC, Henson D, Harper R, Waterman H (2009) Interventions for improving adherence to ocular hypotensive therapy. Cochrane Database Syst Rev 15:CD006132

15.

Robin AL, Covert D (2005) Does adjunctive glaucoma therapy affect adherence to the initial primary therapy? Ophthalmology 112:863–868CrossRefPubMed

16.

Dunker S, Schmucker A, Maier H; Latanoprost/Timolol Fixed Combination Study Group (2007) Tolerability, quality of life, and persistency of use in patients with glaucoma who are switched to the fixed combination of latanoprost and timolol. Adv Ther 24:376–386CrossRef

17.

Skorkovská K (2008) Comparison of intraocular pressure lowering efficacy of bimatoprost/timolol fixed combination and other glaucoma medications in the treatment of glaucoma. Cesk Slov Oftalmol 64:144–148PubMed

18.

Kammer JA, Katzman B, Ackerman SL, Hollander DA (2010) Efficacy and tolerability of bimatoprost versus travoprost in patients previously on latanoprost: a 3-month, randomised, masked-evaluator, multicentre study. Br J Ophthalmol 94:74–79CrossRefPubMed

19.

Centofanti M, Oddone F, Gandolfi S, Hommer A et al (2010) Comparison of travoprost and bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination. Am J Ophthalmol 150:575–580CrossRefPubMed

20.

Konstas AG, Mantziris DA, Stewart WC (1997) Diurnal intraocular pressure in untreated exfoliation and primary open-angle glaucoma. Arch Ophthalmol 115:182–185CrossRefPubMed

21.

Konstas AG, Papapanos P, Tersis I, Houliara D, Stewart WC (2003) Twenty-four hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination. Ophthalmology 110:1357–1360CrossRefPubMed

22.

Gautam N, Kaur S, Kaushik S, Raj S, Pandav SS (2015) Postural and diurnalfluctuations in intraocular pressure across the spectrum of glaucoma. Br J Ophthalmol 12.pii: bjophthalmol-2015-306861. doi:10.1136/bjophthalmol-2015-306861

23.

Tsukahara S, Sasaki T (1984) Postural change of IOP in normal persons and in patients with primary wide open-angle glaucoma and low-tension glaucoma. Br J Ophthalmol 68:389–392CrossRefPubMedPubMedCentral

24.

Fogagnolo P, Rossetti L, Mazzolani F et al (2006) Circadian variations in central corneal thickness and intraocular pressure in patients with glaucoma. Br J Ophthalmol 90:24–28CrossRefPubMedPubMedCentral

Title: The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP
Authors: Suzan Guven Yilmaz
Cumali Degirmenci
Yunus Emre Karakoyun
Emil Yusifov
Halil Ates
Publication date: 01-08-2018
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 4/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0601-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 4/2018

In vivo and ex vivo evaluation of cell–cell interactions, adhesion and migration in ocular surface of patients undergone excimer laser refractive surgery after topical therapy with different lubricant eyedrops

Choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines: common mistake in reproducibility analysis

Are we overlooking masked bilateral congenital superior oblique palsy in children: is it possible to diagnose before surgery?

Comparison of formulas and methods for high myopia patients requiring intraocular lens powers less than six diopters

Topical bevacizumab treatment in aniridia

Dysfunctional lens syndrome