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International Ophthalmology

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01-06-2018 | Case Report

Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy

Authors: Laura R. Steeples, Paul Spry, Richard W. J. Lee, Ester Carreño

Published in: International Ophthalmology | Issue 3/2018

Abstract

Purpose

To report the clinical outcomes of adalimumab therapy in cases of birdshot chorioretinitis (BCR) with cystoid macular edema (CME) refractory to conventional immunotherapy.

Methods

This is a retrospective case series of three BCR patients treated with adalimumab for refractory CME. The main outcome measure was central subfield thickness (CST) on optical coherence tomography. Any patients treated with local steroids and/or receiving systemic steroids higher than 40 mg prednisolone daily during adalimumab therapy were excluded.

Results

At baseline, all patients were receiving systemic corticosteroids and two second-line immunosuppressive agents. The mean duration of treatment with adalimumab was 31.2 months (range 17.2–52). The mean CST was 327 ± 112.7 μm (mean ± SD) at baseline and 256.2 ± 39.7 μm at 6 months and 235.5 ± 32.5 μm at 12 months. Adalimumab permitted cessation or reduction in the daily dose of oral prednisolone plus withdrawal of a second-line agent in all patients.

Conclusions

In these patients, adalimumab was effective in the treatment of refractory CME.

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Title: Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy
Authors: Laura R. Steeples
Paul Spry
Richard W. J. Lee
Ester Carreño
Publication date: 01-06-2018
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 3/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0592-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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