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International Ophthalmology
Published in: International Ophthalmology 3/2018

01-06-2018 | Original Paper

Sensitivity and specificity of optical coherence tomography angiography (OCT-A) for detection of choroidal neovascularization in real-life practice and varying retinal expertise level

Authors: Vaël Souedan, Eric H. Souied, Violaine Caillaux, Alexandra Miere, Ala El Ameen, Rocio Blanco-Garavito

Published in: International Ophthalmology | Issue 3/2018

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Abstract

Purpose

To evaluate the diagnostic accuracy of OCT angiography (OCT-A) detecting or predicting choroidal neovascularization (CNV), by ophthalmologists of disparate degrees of skills in retinal diseases, using spectral domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) as a standard reference.

Methods

Retrospective observational case series. Patient presenting maculopathy and complete imaging were included. FA, SD-OCT, OCT-A and FA coupled to SD-OCT images were graded independently for presence or absence of CNV by ophthalmologists with varying expertise levels.

Results

Overall sensitivity of OCT-A was 85.62% (95% CI 79.04–90.76%) and specificity was 81.51% (95% CI 73.36–88.03). Sensitivity of FA was 74.51% (95% CI 66.84–81.20), and specificity was 82.35% (95% CI 74.30–88.73). Sensitivity of FA + SD-OCT was 92.72% (95% CI 87.34–96.30), and specificity was 90.91% (95% CI 84.31–95.37).

Conclusion

OCT-A has good sensitivity and specificity for the detection of CNV in all expertise level groups. OCT-A may soon become a routine tool for CNV diagnosis and follow-up.
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Metadata
Title
Sensitivity and specificity of optical coherence tomography angiography (OCT-A) for detection of choroidal neovascularization in real-life practice and varying retinal expertise level
Authors
Vaël Souedan
Eric H. Souied
Violaine Caillaux
Alexandra Miere
Ala El Ameen
Rocio Blanco-Garavito
Publication date
01-06-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 3/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0559-6

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