Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 1/2018

01-02-2018 | Original Paper

The assessment of macular electrophysiology and macular morphology in patients with vitiligo

Authors: Rukiye Aydin, Mustafa Ozsutcu, Sevil Karaman Erdur, Funda Dikkaya, Ali Balevi, Merve Ozbek, Fevzi Senturk

Published in: International Ophthalmology | Issue 1/2018

Login to get access

Abstract

Purpose

We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients.

Methods

Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups.

Results

The mean P1 response amplitudes were significantly decreased in central and peripheral rings of the fovea in patients with vitiligo compared with controls (p = 0.002 and p = 0.006, respectively). There was a tendency toward a prolonged mean implicit time for both central and peripheral in patients with vitiligo compared to controls, however, with no statistical significance (p = 0.453 and p = 0.05, respectively). There was no statistically significant difference in all retinal layers thickness between two groups.

Conclusion

In patients with vitiligo, while photoreceptor segment preserved in SD-OCT, mfERG reduced showing potential decline in central retinal function. This study showed a potential decline in central retinal function in patients with vitiligo even if they have normal fundus appearance and SD-OCT findings.
Literature
1.
Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CCE et al (2012) Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res 25:E1–E13CrossRefPubMedCentralPubMed
2.
Karadag R, Esmer O, Karadag AS, Bilgili SG, Cakici O, Demircan YT et al (2016) Evaluation of ocular findings in patients with vitiligo. Int J Dermatol 55:351–355CrossRefPubMed
3.
Biswas G, Barbhuiya JN, Biswas MC, Islam MN, Dutta S (2003) Clinical pattern of ocular manifestations in vitiligo. J Indian Med Assoc 101:478–480PubMed
4.
Bulbul Baskan E, Baykara M, Ercan I, Tunali S, Yucel A (2006) Vitiligo and ocular findings: a study on possibleassociations. J Eur Acad Dermatol Venereol 20:829–833PubMed
5.
Shoeibi N, Taheri AR, Nikandish M, Omidtabrizi A, Khosravi N (2014) Electrophysiologic evaluation of retinal function in patients with psoriasis and vitiligo. Doc Ophthalmol 128:131–136CrossRefPubMed
6.
Tang M, Pawlyk BS, Kosaras B, Berson EL, Sidman RL (1997) ERG abnormalities in relation to histopathologic findings in vitiligo mutant mice. Exp Eye Res 65:215–222CrossRefPubMed
7.
Perossini M, Turio E, Perossini T, Cei G, Barachini P (2010) Vitiligo: ocular and electrophysiological findings. G Ital Dermatol Venereol 145:141–149PubMed
8.
9.
Sutter EE, Tran D (1992) The field topography of ERG components in man—I. The photopic luminance response. Vis Res 32:433–446CrossRefPubMed
10.
Bearse MA, Sutter EE (1996) Imaging localized retinal dysfunction with the multifocal electroretinogram. J Opt Soc Am A 13:634–640CrossRef
11.
Horio N, Kachi S, Hori K, Okamoto Y, Yamamoto E, Terasaki H et al (2001) Progressive change of optical coherence tomography scans in retinal degeneration slow mice. Arch Ophthalmol 119:1329–1332CrossRefPubMed
12.
Bora N, Defoe D, Smith SB (1999) Evidence of decreased adhesion between the neural retina and retinal pigmented epithelium of the Mitfvit (vitiligo) mutant mouse. Cell Tissue Res 295:65–75CrossRefPubMed
13.
Hood DC, Lin CE, Lazow MA, Locke KG, Zhang X, Birch DG (2009) Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography. Invest Ophthalmol Vis Sci 50:2328–2336CrossRefPubMed
14.
Witkin AJ, Ko TH, Fujimoto JG, Chan A, Drexler W, Schuman JS et al (2006) Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases. Am J Ophthalmol 142:945–952CrossRefPubMedCentralPubMed
15.
Menghini M, Lujan BJ, Zayit-Soudry S, Reema Syed R, Porco TC, Bayabo K et al (2015) Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Invest Ophthalmol Vis Sci 56:372–381CrossRefPubMedCentral
16.
Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, International Society For Clinical Electrophysiology of Vision et al (2012) ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 124:1–13CrossRefPubMed
17.
Smith SB, Bora N, McCool D, Kutty G, Wong P, Kutty RK et al (1995) Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/cluster in expression is increased in the neural retina and in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 36:2193–2201PubMed
18.
Milam AH, Li ZY, Fariss RN (1998) Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res 17:175–205CrossRefPubMed
19.
Sugita T, Kondo M, Piao CH, Ito Y, Terasaki H (2008) Correlation between macular volume and focal macular electroretinogram in patients with retinitis pigmentosa. Invest Ophthalmol Vis Sci 49:3551–3558CrossRefPubMed
20.
Wolsley CJ, Silvestri G, O’Neill J, Saunders KJ, Anderson RS (2009) The association between multifocal electroretinograms and OCT retinal thickness in retinitis pigmentosa patients with good visual acuity. Eye 23:1524–1531CrossRefPubMed
Metadata
Title
The assessment of macular electrophysiology and macular morphology in patients with vitiligo
Authors
Rukiye Aydin
Mustafa Ozsutcu
Sevil Karaman Erdur
Funda Dikkaya
Ali Balevi
Merve Ozbek
Fevzi Senturk
Publication date
01-02-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0452-3

Other articles of this Issue 1/2018

International Ophthalmology 1/2018 Go to the issue

Case Report

A case of mistaken identity: the role of lacrimal gland pleomorphic adenoma tissue diagnosis

Original Paper

Factors associated with corneal epithelial defects after pars plana vitrectomy

Case Report

Total resection combined with osteotomy is more effective for orbital solitary fibrous tumor excision: a report of three cases

Original Paper

Comparative study of 25- versus 20-gauge pars plana capsulotomy and vitrectomy in pediatric cataract surgery

Original Paper

Intravitreal anti-VEGF treatment for subretinal neovascularisation secondary to type 2 idiopathic juxtafoveolar telangiectasia

Case Report

Multimodal imaging in a case of bilateral outer retinitis associated with mumps infection