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01-02-2017 | Original Paper

N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model

Authors: Yasemin Isik Balci, Semra Acer, Ramazan Yagci, Vural Kucukatay, Hakan Sarbay, Kerem Bozkurt, Aziz Polat

Published in: International Ophthalmology | Issue 1/2017

Abstract

Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids are one of the prophylactic treatments for keratoconjunctivitis induced by ARA-C. Forty Wistar-type albino rats were included in this study the rats were divided into four groups. The first group (Group 1) received only ARA-C, the second group (Group 2) received ARA-C and N-acetylcysteine (NAC), the third group (Group 3) received only NAC and the fourth group (Group 4) was the control group. The total oxidant status (TOS), the total antioxidant capacity and the oxidative stress index (OSI) measurements of the cornea and the conjunctiva were evaluated in these four groups. The mean TOS and OSI value was the highest in Group 1 and the lowest in Group 3. The differences in TOS and OSI values were statistically significant between Group 1 and Group 2. There are decreases in TOS and OSI values in rats which received ARA-C with NAC administration. NAC may have a protective effect on ARA-C-induced keratoconjunctivitis.

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Title: N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model
Authors: Yasemin Isik Balci
Semra Acer
Ramazan Yagci
Vural Kucukatay
Hakan Sarbay
Kerem Bozkurt
Aziz Polat
Publication date: 01-02-2017
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2017
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-016-0259-7

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N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model

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