Top

Published in:

01-02-2017 | Original Paper

Occurrence of intraocular air bubbles during intravitreal injections for retinopathy of prematurity

Authors: Emine Alyamac Sukgen, Murat Gunay, Yusuf Kocluk

Published in: International Ophthalmology | Issue 1/2017

Abstract

This study aims to present five cases with retinopathy of prematurity (ROP) who were found to have intraocular air bubbles after intravitreal injection (IVI) treatment. The medical records of 148 infants who underwent IVI for ROP were retrospectively reviewed and the ones who demonstrated post-injection intraocular air bubble formation were recruited. Of the 148 patients (31 babies received ranibizumab, 20 babies received aflibercept, 97 babies received bevacizumab), five were found to have intraocular air bubbles right after the IVI. Two infants received intravitreal ranibizumab and three received intravitreal bevacizumab injections. Although intraocular pressure increased temporarily, no intraocular sterile or infective reactions were observed in the postoperative period. The air bubble was found to resorb spontaneously within 72 h. The occurrence rate of the intravitreal air bubbles in our series was 3.37 % despite previously not been reported in the literature. Due to the intravitreal air injection risk, it is important to be more careful while preparing the intravitreal medication before treatment in premature babies.

Lad EM, Hernandez-Boussard T, Morton JM, Moshfeghi DM (2009) Incidence of retinopathy of prematurity in the United States: 1997 through 2005. Am J Ophthalmol 148(3):451–458CrossRefPubMed

Cryotherapy for Retinopathy of Prematurity Cooperative Group (1990) Multicenter trial of cryotherapy for retinopathy of prematurity. One-year outcome—structure and function. Arch Ophthalmol 108(10):1408–1416CrossRef

Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121(12):1684–1694CrossRef

Mintz-Hittner HA, Kennedy KA, Chuang AZ, Beat-rop Cooperative Group (2011) Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 364(7):603–615CrossRefPubMedPubMedCentral

Lai TY, Liu S, Das S, Lam DS (2015) Intravitreal injection-technique and safety. Asia Pac J Ophthalmol (Phila) 4:321–328CrossRef

Kuniyoshi K, Sugioka K, Sakuramoto H, Kusaka S, Wada N, Shimomura Y (2014) Intravitreal injection of bevacizumab for retinopathy of prematurity. Jpn J Ophthalmol 58(3):237–243CrossRefPubMed

Wu WC, Kuo HK, Yeh PT, Yang CM, Lai CC, Chen SN (2013) An updated study of the use of bevacizumab in the treatment of patients with prethreshold retinopathy of prematurity in taiwan. Am J Ophthalmol 155(1):150–158CrossRefPubMed

Somner JE, Mansfield D (2009) In advertent injection of intravitreal air during intravitreal Lucentis injection for wet age-related macular degeneration: an un described complication. Eye 23(8):1744CrossRefPubMed

Castellanos MA, Schwartz S, García-Aguirre G, Quiroz-Mercado H (2013) Short-term out come after intravitreal ranibizumab injections for the treatment of retinopathy of prematurity. Br J Ophthalmol 97(7):816–819CrossRefPubMed

10.

Hwang CK, Hubbard GB, Hutchinson AK, Lambert SR (2015) Outcomes after intravitreal bevacizumab versus laser photocoagulation for retinopathy of prematurity: a 5-year retrospective analysis. Ophthalmology 122(5):1008–1015CrossRefPubMedPubMedCentral

11.

Yetik H, Gunay M, Sirop S, Salihoglu Z (2015) Intravitreal bevacizumab monotherapy for type-1 prethreshold, threshold, and aggressive posterior retinopathy of prematurity—27 month follow-up results from Turkey. Graefes Arch Clin Exp Ophthalmol 253(10):1677–1683CrossRefPubMed

12.

Shima C, Sakaguchi H, Gomi F, Kamei M, Ikuno Y, Oshima Y, Sawa M, Tsujikawa M, Kusaka S, Tano Y (2008) Complications in patients after intravitreal injection of bevacizumab. Acta Ophthalmol 86(4):372–376CrossRefPubMed

13.

Yun C, Oh J, Hwang SY, Kim SW, Huh K (2015) Subconjunctival hemorrhage after intravitreal injection of anti-vascular endothelial growth factor. Graefes Arch Clin Exp Ophthalmol 253(9):1465–1470CrossRefPubMed

14.

Erdogan G, Gunay BO, Unlu C, Gunay M, Ergin A (2015) Management of iatrogenic crystalline lens injury occurred during intravitreal injection. Int Ophthalmol: 1–4 [Epub ahead of print]

15.

Weismann LE, Stoll BJ, Kueser TJ, Rubio TT, Frank CG, Heiman HS et al (1994) Intravenous immune globulin prophylaxis of late-onset sepsis in premature neonates. J Pediatr 125:922–930CrossRef

Title: Occurrence of intraocular air bubbles during intravitreal injections for retinopathy of prematurity
Authors: Emine Alyamac Sukgen
Murat Gunay
Yusuf Kocluk
Publication date: 01-02-2017
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2017
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-016-0257-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Occurrence of intraocular air bubbles during intravitreal injections for retinopathy of prematurity

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2017

Influence of surface light scattering in hydrophobic acrylic intraocular lenses on laser beam transmittance

Comparison of early dexamethasone retreatment versus standard dexamethasone regimen combined with PRN ranibizumab in diabetic macular edema

Comparison of intraocular pressure variability in glaucoma measured by multiple clinicians with those by one clinician

Corneal graft dellen in a patient implanted with a Boston keratoprosthesis type 1

Subfoveal choroidal thickness changes after intravitreal bevacizumab injection for neovascular age-related macular degeneration and diabetic macular edema

Long-term outcome of amniotic membrane transplantation combined with mitomycin C for conjunctival reconstruction after ocular surface squamous neoplasia excision