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01-02-2017 | Original Paper

Relationship between mean platelet volume and central serous chorioretinopathy

Authors: Ayhan Dursun, Mustafa Ilker Toker, Ayşe Vural Ozec, Erman Bozali, Kadir Kirboga, Feyza Gulac Dursun, Haydar Erdogan, Aysen Topalkara, Mustafa Kemal Arici

Published in: International Ophthalmology | Issue 1/2017

Abstract

The aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 ± 1.36 fL) compared with the control subjects (8.37 ± 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 ± 53.75 and 243 ± 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was >9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.

Nicholson B, Noble J, Forooghian F, Meyerle C (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58:103–126CrossRefPubMedPubMedCentral

Caccavale A, Romanazzi F, Imparato M, Negri A, Morano A, Ferentini F (2010) Low-dose aspirin as treatment for central serous chorioretinopathy. Clin Ophthalmol 4:899–903CrossRefPubMedPubMedCentral

Wang M, Munch IC, Hasler PW, Pürünte C, Larsen M (2008) Central serous chorioretinopathy. Acta Ophthalmol 86:126–145CrossRefPubMed

Miki A, Kondo N, Yanagisawa S, Bessho H, Honda S, Negi A (2014) Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy. Ophthalmology 121:1067–1072CrossRefPubMed

Tittl MK, Spaide RF, Wong D et al (1999) Systemic findings associated with central serous chorioretinopathy. Am J Ophthalmol 128:63–68CrossRefPubMed

Tewari HK, Gadia R, Kumar D, Venkatesh P, Garg SP (2006) Sympathetic parasympathetic activity and reactivity in central serous chorioretinopathy: a case–control study. Invest Ophthalmol Vis Sci 47:3474–3478CrossRefPubMed

Haimovici R, Koh S, Gagnon DR, Lehrfeld T, Wellik S (2004) Central serous chorioretinopathy case–control study group. Risk factors for central serous chorioretinopathy: a case–control study. Ophthalmology 111:244–249CrossRefPubMed

Zakir SM, Shukla M, Simi ZU, Ahmad J, Sajid M (2009) Serum cortisol and testosterone levels in idiopathic central serous chorioretinopathy. Indian J Ophthalmol 57:419–422CrossRefPubMedPubMedCentral

Yannuzzi LA (1986) Type A behavior and central serous chorioretinopathy. Trans Am Ophthalmol Soc 84:799–845PubMedPubMedCentral

10.

Mansuetta CC, Mason JO 3rd, Swanner J et al (2004) An association between central serous chorioretinopathy and gastroesophageal reflux disease. Am J Ophthalmol 137:1096–1100CrossRefPubMed

11.

Kloos P, Laube I, Thoelen A (2008) Obstructive sleep apnea in patients with central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 246:1225–1228CrossRefPubMed

12.

Chu SG, Becker RC, Berger PB et al (2010) Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 8:148–156CrossRefPubMed

13.

Sahin A, Sahin M, Yüksel H et al (2013) The mean platelet volume in patients with retinal vein occlusion. J Ophthalmol 2013:236371PubMedPubMedCentral

14.

Yazgan S, Celik U, Kaldrm H, Ayar O, Akdemir MO (2015) Plateletcrit in ocular pseudoexfoliation syndrome. Eye Contact Lens. doi:10.1097/ICL.0000000000000197 PubMed

15.

Tao Y, Dong Y, Lu CW, Yang W, Li Q (2015) Relationship between mean platelet volume and retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 253:1791–1794CrossRefPubMed

16.

Ates O, Kiki I, Bilen H et al (2009) Association of mean platelet volume with the degree of retinopathy in patients with diabetes mellitus. Eur J Gen Med 6:99–102

17.

Yannuzzi LA (2010) Central serous chorioretinopathy: a personal perspective. Am J Ophthalmol 149:361–363CrossRefPubMed

18.

Piccolino FC, Borgia L (1994) Central serous chorioretinopathy and indocyanine green angiography. Retina 14:231–242CrossRefPubMed

19.

Prünte C, Flammer J (1996) Choroidal capillary and venous congestion in central serous retinopathy. Am J Ophthalmol 121:26–34CrossRefPubMed

20.

Kitaya N, Nagaoka T, Hikichi T, Sugawara R, Fukui K, Ishiko S, Yoshida A (2003) Features of abnormal choroidal circulation in central serous chorioretinopathy. Br J Ophthalmol 87:709–712CrossRefPubMedPubMedCentral

21.

Hirami Y, Tsujikawa A, Sasahara M et al (2007) Alterations of retinal pigment epithelium in central serous chorioretinopathy. Clin Exp Ophthalmol 35:225–230CrossRefPubMed

22.

Liegl R, Ulbig MW (2014) Central serous chorioretinopathy. Ophthalmologica 232:65–76CrossRefPubMed

23.

Sun J, Tan J, Wang Z, Yang H, Zhu X, Li L (2003) Effect of catecholamine on central serous chorioretinopathy. J Huazhong Univ Sci Technol Med Sci 23:313–316CrossRefPubMed

24.

Thoelen AM, Bernasconi PP, Schmid C, Messmer EP (2000) Central serous chorioretinopathy associated with a carcinoma of the adrenal cortex. Retina 20:98–99CrossRefPubMed

25.

Loo JL, Lee SY, Ang CL (2006) Can long-term corticosteroids lead to blindness? A case series of central serous chorioretinopathy induced by corticosteroids. Ann Acad Med Singap 35:496–499PubMed

26.

Moon SJ, Mieler WF (2003) Retinal complication of bone marrow and solid organ transplantation. Curr Opin Ophthalmol 14:433–442CrossRefPubMed

27.

Shah VA, Randhawa S, Boldt HC, Lee AG (2006) Central serous chorioretinopathy in giant cell arteritis. Semin Ophthalmol 21:45–48CrossRefPubMed

28.

Smith NM, Pathansali R, Bath PM (1999) Platelets and stroke. Vasc Med 4:165–172CrossRefPubMed

29.

Kiliçli Çamur N, Demirtunç R, Konuralp C, Eskiser A, Başaran Y (2005) Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit 11:387–392

30.

Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W (2004) Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 35:1688–1691CrossRefPubMed

31.

Bath PM, Butterworth RJ (1996) Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7:157–161CrossRefPubMed

32.

Papanas N, Symeonidis G, Maltezos E et al (2004) Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 15:475–478CrossRefPubMed

33.

Nadar S, Blann AD, Lip GY (2004) Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. Ann Med 36:552–557CrossRefPubMed

34.

Hendra TJ, Oswald GA, Yudkin JS (1988) Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes Res Clin Pract 5:63–69CrossRefPubMed

35.

Cil H, Yavuz C, Islamoglu Y et al (2012) Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 18:650–653CrossRefPubMed

36.

Hekimsoy Z, Payzin B, Ornek T, Kandogan G (2004) Mean platelet volume in type 2 diabetic patients. J Diabetes Complicat 18:173–176CrossRefPubMed

37.

Türkcü FM, Yüksel H, Sahin A et al (2014) Mean platelet volume in pseudoexfoliation syndrome and glaucoma. Eur J Ophthalmol 24:71–75CrossRefPubMed

38.

Ayhan Tuzcu E, Arıca S, Ilhan N et al (2014) Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 252:237–240CrossRefPubMed

39.

Sahin M, Sahin A, Elbey B, Yüksel H, Türkcü FM, Cingü AK (2016) Mean platelet volume in patients with nonarteritic anterior ischemic optic neuropathy. J Ophthalmol 2016:1051572CrossRefPubMedPubMedCentral

40.

Sahin M, Sahin A, Yüksel H, Türkcü FM, Yildirim A (2016) Mean platelet volume in patients with retinal artery occlusion. Arq Bras Oftalmol 79:12–14CrossRefPubMed

41.

Okushiba U, Takeda M (1997) Study of choroidal vascular lesions in central serous chorioretinopathy using indocyanine green angiography. Nihon Ganka Gakkai Zasshi 101:74–82PubMed

42.

Chan WM, Lai TY, Lai RY, Tang EW, Liu DT, Lam DS (2008) Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy: one-year results of a prospective study. Retina 28:85–93CrossRefPubMed

43.

Chang MA, Bressler SB (2009) Photodynamic therapy for chronic pigment epithelial detachment in central serous chorioretinopathy. Can J Ophthalmol 44:221–222CrossRefPubMed

44.

Iijima H, Iida T, Murayama K, Imai M, Gohdo T (1999) Plasminogen activator inhibitor 1 in central serous chorioretinopathy. Am J Ophthalmol 127:477–478CrossRefPubMed

45.

Canan F, Dikici S, Kutlucan A et al (2012) Association of mean platelet volume with DSM-IV major depression in a large community-based population: the MELEN study. J Psychiatr Res 46:298–302CrossRefPubMed

46.

Sahin A, Bez Y, Kaya MC, Türkcü FM, Sahin M, Yüksel H (2014) Psychological distress and poor quality of life in patients with central serous chorioretinopathy. Semin Ophthalmol 29:73–76CrossRefPubMed

47.

Varol E, Icli A, Kocyigit S, Erdogan D, Ozaydin M, Dogan A (2013) Effect of smoking cessation on mean platelet volume. Clin Appl Thromb Hemost 19:315–319CrossRefPubMed

48.

Türkcü FM, Yüksel H, Sahin A et al (2014) Effects of smoking on visual acuity of central serous chorioretinopathy patients. Cutan Ocul Toxicol 33:115–119CrossRefPubMed

Title: Relationship between mean platelet volume and central serous chorioretinopathy
Authors: Ayhan Dursun
Mustafa Ilker Toker
Ayşe Vural Ozec
Erman Bozali
Kadir Kirboga
Feyza Gulac Dursun
Haydar Erdogan
Aysen Topalkara
Mustafa Kemal Arici
Publication date: 01-02-2017
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2017
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-016-0237-0

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Relationship between mean platelet volume and central serous chorioretinopathy

Abstract

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Abstract

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