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01-10-2011 | Original Paper

Intraocular pressure reduction in normal-tension glaucoma patients in South Korea

Authors: Kyoung Tak Ma, Chan Yun Kim, Gong Je Seong, Seung Hyuck Lee, Jong Woon Park, Seung Joo Ha, Byung Joo Cho, Jeanette A. Stewart, Michael S. Kristoffersen, Lindsay A. Nelson, William C. Stewart

Published in: International Ophthalmology | Issue 5/2011

Abstract

To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression was identified by Advanced Glaucoma Intervention Study visual field scoring. There were 90 (42%) progressed patients and 127 (58%) stable patients included in the study. Mean IOP measured higher in the progressed (14.3 ± 2.2 mmHg) than stable patients (14.0 ± 1.9 mmHg), but was not statistically different between the groups (P = 0.29). The mean IOP that best discriminated stable patients was ≤15 mmHg, but no statistical difference existed in the numbers of progressed versus stable patients at ≤15 mmHg compared to >15 mmHg (P = 0.07). Multivariate regression analysis showed that the baseline number of glaucoma medicines and visual field as well as mean, peak and fluctuation of IOP were significant risk factors for glaucomatous progression (P < 0.01). This study suggests that in Korean NTG patients, despite relatively similar IOPs between progressed and stable patients, and based on multivariate regression analysis, IOP may be a risk factor for glaucomatous progression.

Collaborative Normal-Tension Glaucoma Study Group (1998) The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol 126:498–505CrossRef

Stewart WC (1990) Clinical practice of glaucoma. SLACK, Inc., Thorofare, pp 73–127, 141–144

Shiose Y, Kitazawa Y, Tsukahara S, Akamatsu T, Mizokami K, Futa R, Katsushima H, Kosaki H (1991) Epidemiology of glaucoma in Japan—a nationwide glaucoma survey. Jpn J Ophthalmol 35:133–155PubMed

Choe YJ (1993) The prevalence of glaucoma in Korean adults. J Korean Ophthalmol Soc 34:65–69

Omoto K, Saitou N (1997) Genetic origins of the Japanese: a partial support for the dual structure hypothesis. Am J Phys Anthropol 102:437–446PubMedCrossRef

Werner EB (1996) Normal-tension glaucoma. In: Ritch R, Shields MB, Krupin T (eds) The glaucomas. Mosby, St. Louis, pp 769–797

Suzuki S, Suzuki Y, Iwase A, Araie M (2005) Corneal thickness in an ophthalmologically normal Japanese population. Ophthalmology 112:1327–1336PubMedCrossRef

Stewart WC, Jenkins JN, Stewart JA (2005) Corneal thickness after refractive surgery. Ophthalmology 112:1637PubMedCrossRef

Wu LL, Suzuki Y, Ideta R, Araie M (2000) Central corneal thickness of normal tension glaucoma patients in Japan. Jpn J Ophthalmol 44:643–647PubMedCrossRef

10.

Tang S, Toda Y, Kashiwagi K, Mabuchi F, Iijima H, Tsukahara S, Yamagata Z (2003) The association between Japanese primary open-angle glaucoma and normal tension glaucoma patients and the optineurin gene. Hum Genet 113:276–279PubMedCrossRef

11.

Woo SJ, Kim DM, Kim JY, Park SS, Ko HS, Yoo T (2004) Investigation of the association between OPA1 polymorphisms and normal-tension glaucoma in Korea. J Glaucoma 13:492–495PubMedCrossRef

12.

Umeda T, Matsuo T, Nagayama M, Tamura N, Tanabe Y, Ohtsuki H (2004) Clinical relevance of optineurin sequence alterations in Japanese glaucoma patients. Ophthalmic Genet 25:91–99PubMedCrossRef

13.

Fuse N, Takahashi K, Akiyama H, Nakazawa T, Seimiya M, Kuwahara S, Tamai M (2004) Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. J Glaucoma 13:299–303PubMedCrossRef

14.

Nakatsue T, Shirakashi M, Yaoeda K, Funaki S, Funaki H, Fukushima A, Ofuchi N, Abe H (2004) Optic disc topography as measured by confocal scanning laser ophthalmoscopy and visual field loss in Japanese patients with primary open-angle or normal-tension glaucoma. J Glaucoma 13:291–298PubMedCrossRef

15.

Yang JG, Park KH (1997) A comparison of optic nerve head topography in primary open-angle glaucoma and normal-tension glaucoma in Korean. Korean J Ophthalmol 11:79–83PubMed

16.

Seong GJ, Rho SH, Kim CS, Moon JI, Kook MS, Kim YY, Ma KT, Hong YJ, Nelson LA, Kruft B, Stewart JA, Stewart WC (2009) Potential benefits of intraocular pressure reduction in normal-tension glaucoma in South Korea. J Ocul Pharmacol Ther 25:91–96PubMedCrossRef

17.

Shields MB (1987) Textbook of glaucoma, 2nd edn. Williams and Wilkins, Baltimore, pp 5–15, 45–70, 105–131

18.

Advanced Glaucoma Intervention Study 2 (1994) Visual field test scoring and reliability. Ophthalmology 101:1445–1455

19.

Book SA (1978) Essentials of statistics. McGraw-Hill, New York, pp. 122, 205

20.

Moses LE, Emerson JD, Hosseini H (1984) Statistics in practice. Analyzing data from ordered categories. N Engl J Med 311:442PubMedCrossRef

Title: Intraocular pressure reduction in normal-tension glaucoma patients in South Korea
Authors: Kyoung Tak Ma
Chan Yun Kim
Gong Je Seong
Seung Hyuck Lee
Jong Woon Park
Seung Joo Ha
Byung Joo Cho
Jeanette A. Stewart
Michael S. Kristoffersen
Lindsay A. Nelson
William C. Stewart
Publication date: 01-10-2011
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 5/2011
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-011-9463-7

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Intraocular pressure reduction in normal-tension glaucoma patients in South Korea

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