Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 5/2010

01-10-2010 | Original Paper

Sensitivity of laser flare photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis

Authors: Ottavio Bernasconi, Marina Papadia, Carl P. Herbort

Published in: International Ophthalmology | Issue 5/2010

Login to get access

Abstract

To study the sensitivity of laser flare photometry (LFP) in monitoring anterior chamber inflammation by correlating LFP measurements with slit-lamp evaluation of aqueous cells in HLA-B27-related uveitis in a prospective trial. Slit-lamp cell evaluation was correlated with LFP-measured flare in a masked fashion in HLA-B27-related uveitis patients receiving standard topical therapy. At the time of 50 and 90% LFP flare reduction, the corresponding reduction of cells was recorded and statistically compared using the sign test. Forty-three episodes (in 43 patients) of acute anterior HLA-B27-related uveitis were included. LFP flare reduction and slit-lamp cell reduction were strongly correlated. LFP was significantly more sensitive for both 50% (P = 0.001) and 90% (P = 0.02) LFP flare reduction in assessing the decrease of anterior chamber inflammation. LFP was superior to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis. Flare, becoming a quantitative parameter when measured by LFP, rather than cells, should be considered the gold standard to measure anterior chamber inflammation in uveitis.
Literature
1.
Hogan MJ, Kimura SJ, Thygeson P (1959) Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol 47(no. 5, pt. 2):155–170
2.
Kimura SJ, Thygeson P, Hogan MJ (1959) Signs and symptoms of uveitis. II. Classification of the posterior manifestations of uveitis. Am J Ophthalmol 47 (no. 5, pt. 2):171–176
3.
SUN Working group (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509–516CrossRef
4.
Kanski J (1987) Introduction. In: Kanski J (ed) Uveitis: a colour manual of diagnosis and treatment. Butterworths, London, pp 1–11
5.
6.
Sawa M, Tsurimaki Y, Tsuru T, Shimizu H (1988) New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol 32:132–142PubMed
7.
El-Maghraby A, Marzouki A, Matheen TM et al (1992) Reproducibility and validity of laser flare/cell meter measurements as an objective method of assessing intraocular inflammation. Arch Ophthalmol 110:960–962PubMed
8.
Castella AP, Bercher L, Zografos L, Egger E, Herbort CP (1995) Study of blood–aqueous barrier in choroidal melanoma. Br J Ophthalmol 79:354–357CrossRefPubMed
9.
Mermoud A, Pittet N, Herbort CP (1992) Inflammation patterns after laser trabeculoplasty measured with the laser flare meter. Arch Ophthalmol 110:368–370PubMed
10.
Herbort CP, Mermoud A, Schnyder C, Pittet N (1993) Anti-inflammatory effect of diclofenac drops after argon laser trabeculoplasty. Arch Ophthalmol 111:481–483PubMed
11.
Herbort CP, Jauch A, Othenin-Girard P, Tritten JJ, Fsadni M (2000) Diclofenac drops to treat inflammation after cataract surgery. Acta Ophthalmol Scand 78:421–424CrossRefPubMed
12.
Guex-Crosier Y, Pittet N, Herbort CP (1995) Sensitivity of laser flare photometry to monitor inflammation in uveitis of the posterior segment. Ophthalmology 102:613–621PubMed
13.
Sawa M (1990) Clinical application of laser flare-cell meter. Jpn J Ophthalmol 34:346–363PubMed
14.
Shah SM, Spalton DJ, Taylor JC (1992) Correlations between laser flare measurements and anterior chamber protein concentrations. Invest Ophthalmol Vis Sci 33:2878–2884PubMed
15.
Shah SM, Spalton DJ, Smith SE (1991) Measurement of aqueous cells and flare in normal eyes. Br J Ophthalmol 75:348–352CrossRefPubMed
16.
De Ancos E, Pittet N, Herbort CP (1994) Mesure quantitative de l’inflammation dans l’uvéite antérieure aiguë (UAA) HLA B27 à l’aide du laser flare-cell meter Kowa FC-1000. Klin Monatsbl Augenheilkd 204:330–333CrossRefPubMed
17.
Herbort CP, Guex-Crosier Y, de Ancos E, Pittet N (1997) Use of laser flare photometry (LFP) to assess and monitor inflammation in uveitis. Ophthalmology 104:64–72PubMed
18.
Tugal-Tutkun I, Cingü K, Kir N, Yeniad B, Urgancioglu M, Gül A (2008) Use of laser flare-cell photometry to quantify intraocular inflammation in patients with Behçet’s uveitis. Graefes Arch Clin Exp Ophthalmol 246:1169–1177CrossRefPubMed
19.
Fang W, Zhou H, Yang P, Huang X, Wang L, Kijlstra A (2008) Longitudinal quantification of aqueous flare and cells in Vogt–Koyanagi–Harada disease. Br J Ophthalmol 92:182–185CrossRefPubMed
20.
Herbort CP (2009) Laser flare photometry. In: Gupta A, Gupta V, Herbort CP, Khairallah M (eds) Uveitis: text and imaging. New Delhi, Jaypee, pp 28–49
Metadata
Title
Sensitivity of laser flare photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis
Authors
Ottavio Bernasconi
Marina Papadia
Carl P. Herbort
Publication date
01-10-2010
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2010
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-010-9386-8

Other articles of this Issue 5/2010

International Ophthalmology 5/2010 Go to the issue

Case Report

Sympathetic ophthalmia manifesting with conjunctival chemosis

EditorialNotes

Editorial: Fuchs’ uveitis: from Imperial Vienna to global appraisal

Original Paper

Effects of infliximab in the treatment of refractory posterior uveitis of Behçet’s disease after withdrawal of infusions

Original Paper

Anti-tuberculous therapy combined with systemic corticosteroids improves retinal sensitivity in patients with active presumed tuberculous choroiditis

Original Paper

Association of systemic steroids and mycophenolate mofetil as rescue therapy for uveitic choroidal neovascularization unresponsive to the traditional immunesuppressants: interventional case series

Original Paper

Cotton wool spots as possible indicators of retinal vascular pathology in ocular lyme borreliosis