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International Ophthalmology
Published in: International Ophthalmology 4/2009

01-08-2009 | Case Report

Primary acquired melanosis with atypia treated with mitomycin C

Authors: Wendy V. Anandajeya, Zélia M. Corrêa, James J. Augsburger

Published in: International Ophthalmology | Issue 4/2009

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Abstract

The authors report the case of a 56-year-old Caucasian man who was found to have prominent melanotic conjuntival pigmentation inferotemporally in his right eye. Histopathologic evaluation disclosed malignant melanoma of the conjunctiva arising within primary acquired melanosis (PAM) associated with melanocytic atypia. The patient was treated by incisional conjunctival biopsy followed by two cycles of mitomycin C 0.04% eye drops and supplemental double-freeze thaw cryotherapy to residual foci of PAM. By 1 year following this treatment, there was no clinically apparent residual conjunctival melanosis, and visual acuity remained stable at 20/30.
Literature
1.
Jakobiec FA, Folberg R, Iwamoto T (1989) Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva. Ophthalmology 96(2):147–166PubMed
2.
Chalasani R, Giblin M, Conway RM (2006) Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment. Clin Exp Ophthalmol 34(7):708–714CrossRef
3.
Kurli M, Finger PT (2005) Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years’ experience. Graefes Arch Clin Exp Ophthalmol 243(11):1108–1114PubMedCrossRef
4.
Pe’er J, Frucht-Pery J (2005) The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C. Am J Opthalmol 139(2):229–234CrossRef
Metadata
Title
Primary acquired melanosis with atypia treated with mitomycin C
Authors
Wendy V. Anandajeya
Zélia M. Corrêa
James J. Augsburger
Publication date
01-08-2009
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 4/2009
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-008-9225-3

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