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International Ophthalmology
Published in: International Ophthalmology 1/2008

01-02-2008 | Case Report

Localized conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is amenable to local chemotherapy

Authors: Carol S. Yu, Suk I. Chiu, Chi S. Ng, Henry H. Chan, Raymond K. Tse

Published in: International Ophthalmology | Issue 1/2008

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Abstract

Purpose Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is a rare, low-grade, non-Hodgkin’s B-cell lymphoma. We report our successful management of localized conjunctival MALT lymphoma with topical Mitomycin C (MMC). Methods This is a case report. A 35-year-old woman had a mobile painless 1.5 × 1-cm mass in the left conjunctiva for 2 years. Examination revealed two similar masses in the right conjunctiva. Incisional biopsy for immunohistochemical stain and PCR of the left conjunctival mass showed MALT lymphoma. She was given four courses of topical 0.04% MMC eyedrops. There was transient conjunctival injection and superficial punctate keratopathy which responded to topical steroid and lubricant. Results The lesions regressed completely after the fourth cycle of treatment and repeat biopsy confirmed complete remission. Conclusion This is the first report of localized conjunctival MALT lymphoma being successfully treated by topical MMC with minimal local controllable side effects.
Literature
1.
Isaacson PG (1990) Lymphoma of the mucosa-associated lymphoid tissue (MALT). Histopathology 16:617–619PubMedCrossRef
2.
Bessell EM, Henk JM, Whitelocke RA et al (1987) Ocular morbidity after radiotherapy of orbital and conjunctival lymphoma. Eye 1:90–96PubMed
3.
Blasi MA, Gherlinzoni F, Calvisi G et al (2001) Local chemotherapy with interferon-alpha for conjunctival mucosa-associated lymphoid tissue lymphoma: a preliminary report. Ophthalmology 108(3):559–662PubMedCrossRef
4.
Hardman-Lea S, Kerr-Muir M, Wotherspoon AC et al (1994) Mucosal-associated lymphoid tissue lymphoma of the conjunctiva. Arch Ophthalmol 112:1207–1212PubMed
5.
Nückel H, Meller D, Steuhl K-P, Dührsen U (2004) Anti-CD20 monoclonal antibody therapy in relapsed MALT lymphoma of the conjunctiva. Eur J Haematol 73:258–262PubMedCrossRef
6.
Frucht-Pery J, Rozenman Y (1994) Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol 117:164–168PubMed
7.
Shields CL, Shields JA, Carvalho C, Rundle P, Smith AF (2001) Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology 108:979–984PubMedCrossRef
8.
Ando H, Ido T, Kawai Y, Yamamoto T, Kitazawa Y (1992) Inhibition of corneal epithelial wound healing. A comparative study of mitomycin C and 5-fluorouracil. Ophthalmology 99:1809–1814PubMed
Metadata
Title
Localized conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is amenable to local chemotherapy
Authors
Carol S. Yu
Suk I. Chiu
Chi S. Ng
Henry H. Chan
Raymond K. Tse
Publication date
01-02-2008
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2008
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-007-9102-5

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