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01-02-2020 | Colchicine | Review

Anti-inflammatory drugs in the prevention of post-operative atrial fibrillation: a literature review

Authors: Homa Nomani, Amir Hooshang Mohammadpour, Seyed Mohammad Hassan Moallem, Amirhossein Sahebkar

Published in: Inflammopharmacology | Issue 1/2020

Abstract

Atrial fibrillation (AF) is a serious and common complication following heart surgery. Cardiac surgery triggers inflammation in the heart and makes it susceptible to the incidence of AF. Therefore, anti-inflammatory drugs may reduce the rate of AF incidence in the post-surgery conditions. Immunosuppressant agents, steroidal anti-inflammatory drugs (corticosteroids), non-aspirin non-steroid anti-inflammatory drugs (NSAIDs), colchicine and omega-3 unsaturated fatty acids (n-3 UFA) are drugs with well-known anti-inflammatory properties. The efficacy, safety and other aspects of using these drugs in the prevention of post-operative AF (POAF) have been reviewed here. Studies evaluating the efficacy of colchicine have shown that it could be effective in the prevention of POAF. However, there is a need for additional studies to find a colchicine regimen with optimal efficacy and higher tolerability. The use of corticosteroids may also be of value based on the most of meta-analyses. In the case of n-3 polyunsaturated fatty acids and NSAIDs, current data fail to support their efficacy in POAF prevention. Moreover, perioperative administration of NSAIDs may be associated with some severe safety considerations. Immunosuppressant agents have not been used for the prevention of POAF. Further studies are needed to find the most effective strategy for POAF prevention with the least safety considerations and the highest health benefits.

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Title: Anti-inflammatory drugs in the prevention of post-operative atrial fibrillation: a literature review
Authors: Homa Nomani
Amir Hooshang Mohammadpour
Seyed Mohammad Hassan Moallem
Amirhossein Sahebkar
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keywords: Colchicine
Heart Surgery
Heart Surgery
Atrial Fibrillation
CABG
CABG
Published in: Inflammopharmacology / Issue 1/2020
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-019-00653-x

At a glance: The STEP trials

Springer Medicine

Anti-inflammatory drugs in the prevention of post-operative atrial fibrillation: a literature review

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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