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01-06-2019 | Original Article

Enoxaparin pretreatment effect on local and systemic inflammation biomarkers in the animal burn model

Authors: Hember Vicci, Antonio Eblen-Zajjur, Mercedes López, Gustavo Crespo, Maria Navarro

Published in: Inflammopharmacology | Issue 3/2019

Abstract

Low-molecular weight heparins (LMWH) are anticoagulants that have shown anti-inflammatory activity in several experimental models. Hot water burn inflammatory model accurately simulates human clinical situations allowing its use for nociception test and evaluation of anti-inflammatory drugs. The present study aims to evaluate the enoxaparin pretreatment on local and systemic inflammation biomarkers in the animal burn model. Inflammation was induced by submersing the rat left hind paw in water at 60^o C for 60 s. C-reactive protein (CRP) and thrombin–antithrombin complex (TAT) were estimated by immunosorbent assay, fibrinogen (Fg) by the gravimetric method and paw oedema by orthogonal digital photography. Highest values of paw oedema, CRP and TAT were observed at 4 h post-burn while Fg peak occurs at 12 h post-burn; enoxaparin pretreatment decreased oedema (− 32.1%), and concentration of TAT (− 66.7%), PCR (− 37.9%) and Fg (− 8%). This study shows that enoxaparin has local and systemic anti-inflammatory effects and should be considered as a potential adjuvant drug for the treatment of burns.

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Title: Enoxaparin pretreatment effect on local and systemic inflammation biomarkers in the animal burn model
Authors: Hember Vicci
Antonio Eblen-Zajjur
Mercedes López
Gustavo Crespo
Maria Navarro
Publication date: 01-06-2019
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 3/2019
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-018-0444-6

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Enoxaparin pretreatment effect on local and systemic inflammation biomarkers in the animal burn model

Abstract

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Abstract

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