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Published in: Inflammopharmacology 3/2017

01-06-2017 | Review

Potential drug targets and treatment of schizophrenia

Authors: Anil Kumar, Monu Yadav, Milind Parle, Sameer Dhingra, Dinesh K. Dhull

Published in: Inflammopharmacology | Issue 3/2017

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Abstract

Schizophrenia is one of the most prevalent chronic psychiatric disorders that affect 1% of the world’s population. Despite its societal burden, pathophysiology of schizophrenia remains poorly understood. Currently available drugs predominantly control positive symptoms, and often have no or poor control on negative and related cognitive symptoms, which strongly affect functional outcome in schizophrenia. The present article is an attempt to provide a critical review of recent hypothesis to understand pathophysiology of schizophrenia and to highlight exploitable molecular drug targets other than dopaminergic systems to treat and manage schizophrenia effectively.
Literature
go back to reference Akyol O, Zoroglu SS, Armutcu F, Sahin S, Gurel A (2004) Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo 18:377–390PubMed Akyol O, Zoroglu SS, Armutcu F, Sahin S, Gurel A (2004) Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo 18:377–390PubMed
go back to reference Allan ER, Alpert M, Sison CE, Citrome L, Laury G, Berman I (1996) Adjunctive nadolol in the treatment of acutely aggressive schizophrenic patients. J Clin Psychiatry 57:455–459PubMedCrossRef Allan ER, Alpert M, Sison CE, Citrome L, Laury G, Berman I (1996) Adjunctive nadolol in the treatment of acutely aggressive schizophrenic patients. J Clin Psychiatry 57:455–459PubMedCrossRef
go back to reference Altamura AC, Mauri MC, Mantero M, Brunetti M (1987) Clonazepam/haloperidol combination therapy in schizophrenia: a double blind study. Acta Psychiatr Scand 76:702–706PubMedCrossRef Altamura AC, Mauri MC, Mantero M, Brunetti M (1987) Clonazepam/haloperidol combination therapy in schizophrenia: a double blind study. Acta Psychiatr Scand 76:702–706PubMedCrossRef
go back to reference Asevedo E, Gadelha A, Noto C, Mansur RB, Zugman A, Belangero SI, Berberian AA, Scarpato BS, Leclerc E, Teixeira AL, Gama CS, Bressan RA, Brietzke E (2013) Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia. J Psychiatr Res 47:1376–1382PubMedCrossRef Asevedo E, Gadelha A, Noto C, Mansur RB, Zugman A, Belangero SI, Berberian AA, Scarpato BS, Leclerc E, Teixeira AL, Gama CS, Bressan RA, Brietzke E (2013) Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia. J Psychiatr Res 47:1376–1382PubMedCrossRef
go back to reference Bardgett ME, Griffith MS, Foltz RF, Hopkins JA, Massie CM, O’Connell SM (2006) The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage. Neurobiol Learn Memory 85(1):86–94CrossRef Bardgett ME, Griffith MS, Foltz RF, Hopkins JA, Massie CM, O’Connell SM (2006) The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage. Neurobiol Learn Memory 85(1):86–94CrossRef
go back to reference Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083–1152PubMedCrossRef Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083–1152PubMedCrossRef
go back to reference Bartoli F, Dell’Osso B, Crocamo C, Fiorillo A, Ketter TA, Suppes T, Clerici M, Carrà G (2017) Benefits and harms of low and high second-generation antipsychotics doses for bipolar depression: a meta-analysis. J Psychiatr Res 88:38–46PubMedCrossRef Bartoli F, Dell’Osso B, Crocamo C, Fiorillo A, Ketter TA, Suppes T, Clerici M, Carrà G (2017) Benefits and harms of low and high second-generation antipsychotics doses for bipolar depression: a meta-analysis. J Psychiatr Res 88:38–46PubMedCrossRef
go back to reference Berman I, Sapers BL, Chang HH, Losonczy MF, Schmildler J, Green AI (1995) Treatment of obsessive-compulsive symptoms in schizophrenic patients with clomipramine. J Clin Psychopharmacol 15(3):206–210PubMedCrossRef Berman I, Sapers BL, Chang HH, Losonczy MF, Schmildler J, Green AI (1995) Treatment of obsessive-compulsive symptoms in schizophrenic patients with clomipramine. J Clin Psychopharmacol 15(3):206–210PubMedCrossRef
go back to reference Bernstein HG, Bogerts B, Keilhoff G (2005) The many faces of nitric oxide in schizophrenia. A review. Schizophr Res 78:69–86PubMedCrossRef Bernstein HG, Bogerts B, Keilhoff G (2005) The many faces of nitric oxide in schizophrenia. A review. Schizophr Res 78:69–86PubMedCrossRef
go back to reference Binder EB, Kinkead B, Owens MJ, Nemeroff CB (2001) The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. Biol Psychiatry 50:856–872PubMedCrossRef Binder EB, Kinkead B, Owens MJ, Nemeroff CB (2001) The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. Biol Psychiatry 50:856–872PubMedCrossRef
go back to reference Bodkin JA, Cohen BM, Salomon MS, Cannon SE, Zornberg GL, Cole JO (1996) Treatment of negative symptoms in schizophrenia and schizoaffective disorder by selegiline augmentation of antipsychotic medication. A pilot study examining the role of dopamine. J Nerv Ment Dis 184:295–301PubMedCrossRef Bodkin JA, Cohen BM, Salomon MS, Cannon SE, Zornberg GL, Cole JO (1996) Treatment of negative symptoms in schizophrenia and schizoaffective disorder by selegiline augmentation of antipsychotic medication. A pilot study examining the role of dopamine. J Nerv Ment Dis 184:295–301PubMedCrossRef
go back to reference Bredt DS (1999) Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res. 31(6):577–596PubMedCrossRef Bredt DS (1999) Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res. 31(6):577–596PubMedCrossRef
go back to reference Brisch R, Bernstein HG, Krell D, Dobrowolny H, Bielau H, Steiner J, Gos T, Funke S, Stauch R, Knüppel S, Bogerts B (2009) Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia. Brain Res 1269:166–175PubMedCrossRef Brisch R, Bernstein HG, Krell D, Dobrowolny H, Bielau H, Steiner J, Gos T, Funke S, Stauch R, Knüppel S, Bogerts B (2009) Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia. Brain Res 1269:166–175PubMedCrossRef
go back to reference Buchanan RW, Summerfelt A, Tek C, Gold J (2003) An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. Schizophr Res 59:29–33PubMedCrossRef Buchanan RW, Summerfelt A, Tek C, Gold J (2003) An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. Schizophr Res 59:29–33PubMedCrossRef
go back to reference Caceda R, Kinkead B, Nemeroff CB (2006) Neurotensin: role in psychiatric and neurological diseases. Peptides 27:2385–2404PubMedCrossRef Caceda R, Kinkead B, Nemeroff CB (2006) Neurotensin: role in psychiatric and neurological diseases. Peptides 27:2385–2404PubMedCrossRef
go back to reference Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacol 1:179–186CrossRef Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacol 1:179–186CrossRef
go back to reference Carlsson ML, Carlsson A, Nilsson M (2004) Schizophrenia: from dopamine to glutamate and back. Curr Med Chem 11:267–277PubMedCrossRef Carlsson ML, Carlsson A, Nilsson M (2004) Schizophrenia: from dopamine to glutamate and back. Curr Med Chem 11:267–277PubMedCrossRef
go back to reference Carpenter WT Jr, Heinrichs DW, Wagman AM (1988) Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 145:578–583PubMedCrossRef Carpenter WT Jr, Heinrichs DW, Wagman AM (1988) Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 145:578–583PubMedCrossRef
go back to reference Carpenter LL, McDougle CJ, Epperson CN, Price LH (1996) A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder. Drug Saf 15(2):116–134PubMedCrossRef Carpenter LL, McDougle CJ, Epperson CN, Price LH (1996) A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder. Drug Saf 15(2):116–134PubMedCrossRef
go back to reference Caspi N, Modai I, Barak P, Waisbourd A, Zbarsky H, Hirschmann S, Ritsner M (2001) Pindolol augmentation in aggressive schizophrenic patients: a double-blind crossover randomized study. Int Clin Psychopharmacol 16:111–115PubMedCrossRef Caspi N, Modai I, Barak P, Waisbourd A, Zbarsky H, Hirschmann S, Ritsner M (2001) Pindolol augmentation in aggressive schizophrenic patients: a double-blind crossover randomized study. Int Clin Psychopharmacol 16:111–115PubMedCrossRef
go back to reference Chopra K, Baveja A, Kuhad A (2015) MMPs: a novel drug target for schizophrenia. Expert Opin Ther Targets 19(1):77–85PubMedCrossRef Chopra K, Baveja A, Kuhad A (2015) MMPs: a novel drug target for schizophrenia. Expert Opin Ther Targets 19(1):77–85PubMedCrossRef
go back to reference Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R (2011) Oxidative stress in schizophrenia—focusing on the main markers. Psychiatr Danub 23:237–245PubMed Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R (2011) Oxidative stress in schizophrenia—focusing on the main markers. Psychiatr Danub 23:237–245PubMed
go back to reference Cioffi CL (2013) Modulation of NMDA receptor function as a treatment for schizophrenia. Bioorg Med Chem Lett 23:5034–5044PubMedCrossRef Cioffi CL (2013) Modulation of NMDA receptor function as a treatment for schizophrenia. Bioorg Med Chem Lett 23:5034–5044PubMedCrossRef
go back to reference Colquhoun LM, Patrick JW (1997) Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol 39:191–220PubMedCrossRef Colquhoun LM, Patrick JW (1997) Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol 39:191–220PubMedCrossRef
go back to reference Coskran TM, Morton DG, Menniti FS, Adamowicz WO, Kleiman RJ, Ryan AM, Strick CA, Schmidt CJ, Stephenson DT (2006) Immunohistochemical localization of phosphodiesterase 10A, PDE10A, in multiple mammalian species. J Histochem Cytochem 54:1205–1213PubMedCrossRef Coskran TM, Morton DG, Menniti FS, Adamowicz WO, Kleiman RJ, Ryan AM, Strick CA, Schmidt CJ, Stephenson DT (2006) Immunohistochemical localization of phosphodiesterase 10A, PDE10A, in multiple mammalian species. J Histochem Cytochem 54:1205–1213PubMedCrossRef
go back to reference Coyle J (1997) The nagging question of the function of N acetylaspartylglutamate. Neurobiol Dis 4:231–238PubMedCrossRef Coyle J (1997) The nagging question of the function of N acetylaspartylglutamate. Neurobiol Dis 4:231–238PubMedCrossRef
go back to reference Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B (2000) Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation. Biol Psychiatry 48:381–388PubMedCrossRef Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B (2000) Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation. Biol Psychiatry 48:381–388PubMedCrossRef
go back to reference Davis J, Moylan S, Harvey BH, Maes M, Berk M (2014) Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries. Aust NZ J Psychiatry 48:512–529CrossRef Davis J, Moylan S, Harvey BH, Maes M, Berk M (2014) Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries. Aust NZ J Psychiatry 48:512–529CrossRef
go back to reference Dawson LA, Smith PW (2010) Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia. Curr Pharm Des 16:344–357PubMedCrossRef Dawson LA, Smith PW (2010) Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia. Curr Pharm Des 16:344–357PubMedCrossRef
go back to reference De Marchi N, De Petrocellis L, Orlando P, Daniele F, Fezza F, Di Marzo V (2003) Endocannabinoid signalling in the blood of patients with schizophrenia. Lipids Health Dis 2:5PubMedPubMedCentralCrossRef De Marchi N, De Petrocellis L, Orlando P, Daniele F, Fezza F, Di Marzo V (2003) Endocannabinoid signalling in the blood of patients with schizophrenia. Lipids Health Dis 2:5PubMedPubMedCentralCrossRef
go back to reference Dean B, Sundram S, Bradbury R, Scarr E, Copolov D (2001) Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid 1 receptors associated with schizophrenia and cannabis use. Neuroscience 103:9–15PubMedCrossRef Dean B, Sundram S, Bradbury R, Scarr E, Copolov D (2001) Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid 1 receptors associated with schizophrenia and cannabis use. Neuroscience 103:9–15PubMedCrossRef
go back to reference Di Giovanni G, Di Matteo V, Di Mascio M, Esposito E (2000) Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse 35(1):53–61PubMedCrossRef Di Giovanni G, Di Matteo V, Di Mascio M, Esposito E (2000) Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse 35(1):53–61PubMedCrossRef
go back to reference Dietrich-Muszalska A (2015) Oxidative stress in schizophrenia. Studies on psychiatric disorders. Springer, New York, pp 43–72 Dietrich-Muszalska A (2015) Oxidative stress in schizophrenia. Studies on psychiatric disorders. Springer, New York, pp 43–72
go back to reference Dose M, Hellweg R, Yassouridis A, Theison M, Emrich HM (1998) Combined treatment of schizophrenic psychoses with haloperidol and valproate. Pharmacopsychiatry 31:122–125PubMedCrossRef Dose M, Hellweg R, Yassouridis A, Theison M, Emrich HM (1998) Combined treatment of schizophrenic psychoses with haloperidol and valproate. Pharmacopsychiatry 31:122–125PubMedCrossRef
go back to reference Ebstein RP, Biederman J, Rimon R, Zohar J, Belmaker RJ (1976) Cyclic GMP in the CSF of patients with schizophrenia before and after neuroleptic treatment. Psychopharmacology 51(1):71–74PubMedCrossRef Ebstein RP, Biederman J, Rimon R, Zohar J, Belmaker RJ (1976) Cyclic GMP in the CSF of patients with schizophrenia before and after neuroleptic treatment. Psychopharmacology 51(1):71–74PubMedCrossRef
go back to reference Emrich HM, Leweke FM, Schneider U (1997) Towards a cannabinoid hypothesis of schizophrenia: cognitive impairments due to dysregulation of the endogenous cannabinoid system. Pharmacol Biochem Behav 56:803–807PubMedCrossRef Emrich HM, Leweke FM, Schneider U (1997) Towards a cannabinoid hypothesis of schizophrenia: cognitive impairments due to dysregulation of the endogenous cannabinoid system. Pharmacol Biochem Behav 56:803–807PubMedCrossRef
go back to reference Evins AE, Fitzgerald SM, Wine L, Rosselli R, Goff DC (2000) Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry 157:826–828PubMedCrossRef Evins AE, Fitzgerald SM, Wine L, Rosselli R, Goff DC (2000) Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry 157:826–828PubMedCrossRef
go back to reference Feifel D, Reza TL, Wustrow DJ, Davis MD (1999) Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. J Pharmacol Exp Ther 288:710–713PubMed Feifel D, Reza TL, Wustrow DJ, Davis MD (1999) Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. J Pharmacol Exp Ther 288:710–713PubMed
go back to reference Fell MJ, McKinzie DL, Monn JA, Svensson KA (2012) Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia. Neuropharmacology 62:1473–1483PubMedCrossRef Fell MJ, McKinzie DL, Monn JA, Svensson KA (2012) Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia. Neuropharmacology 62:1473–1483PubMedCrossRef
go back to reference Fenton WS, Dickerson F, Boronow J, Hibbeln JR, Knable M (2001) A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 158:2071–2074PubMedCrossRef Fenton WS, Dickerson F, Boronow J, Hibbeln JR, Knable M (2001) A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 158:2071–2074PubMedCrossRef
go back to reference Ferraro L, Tomasini MC, Fuxe K, Agnati LF, Mazza R, Tanganelli S, Antonelli T (2007) Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides. Brain Res Rev 55:144–154PubMedCrossRef Ferraro L, Tomasini MC, Fuxe K, Agnati LF, Mazza R, Tanganelli S, Antonelli T (2007) Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides. Brain Res Rev 55:144–154PubMedCrossRef
go back to reference Finberg JP, Youdim MB (2002) Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours. Neuropharmacology 43:1110–1118PubMedCrossRef Finberg JP, Youdim MB (2002) Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours. Neuropharmacology 43:1110–1118PubMedCrossRef
go back to reference Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 67:1954–1967PubMedCrossRef Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 67:1954–1967PubMedCrossRef
go back to reference Friedman JI, Adler DN, Howanitz E, Harvey PD, Brenner G, Temporini H, White L, Parrella M, Davis KL (2002) A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia. Biol Psychiatry 51:349–357PubMedCrossRef Friedman JI, Adler DN, Howanitz E, Harvey PD, Brenner G, Temporini H, White L, Parrella M, Davis KL (2002) A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia. Biol Psychiatry 51:349–357PubMedCrossRef
go back to reference Ganzinelli S, Borda E, Sterin-Borda L (2010) Autoantibodies from schizophrenia patients induce cerebral cox-1/iNOS mRNA expression with NO/PGE2/MMP-3 production. Int J Neuropsychopharmacol 13:293–303PubMedCrossRef Ganzinelli S, Borda E, Sterin-Borda L (2010) Autoantibodies from schizophrenia patients induce cerebral cox-1/iNOS mRNA expression with NO/PGE2/MMP-3 production. Int J Neuropsychopharmacol 13:293–303PubMedCrossRef
go back to reference Gattaz WF, Carmer H, Beckmann H (1983) Low CSF concentrations of cyclic GMP in schizophrenia. Br J Psychiatry 142:288–291PubMedCrossRef Gattaz WF, Carmer H, Beckmann H (1983) Low CSF concentrations of cyclic GMP in schizophrenia. Br J Psychiatry 142:288–291PubMedCrossRef
go back to reference Goff DC, Coyle JT (2001) The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 158:1367–1377PubMedCrossRef Goff DC, Coyle JT (2001) The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 158:1367–1377PubMedCrossRef
go back to reference Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT (1999) A placebo-controlled trial of d-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry 56:21–27PubMedCrossRef Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT (1999) A placebo-controlled trial of d-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry 56:21–27PubMedCrossRef
go back to reference Gray JA, Roth BL (2007) The pipeline and future of drug development in schizophrenia. Mol Psychiatry 12(10):904–922PubMedCrossRef Gray JA, Roth BL (2007) The pipeline and future of drug development in schizophrenia. Mol Psychiatry 12(10):904–922PubMedCrossRef
go back to reference Griebel G, Beeske S (2011) Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases? Pharmacol Ther 133:116–123PubMedCrossRef Griebel G, Beeske S (2011) Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases? Pharmacol Ther 133:116–123PubMedCrossRef
go back to reference Gupta VK, Sharma SK (2006) Plants as natural antioxidants. Nat Prod Radiance. 5(4):326–334 Gupta VK, Sharma SK (2006) Plants as natural antioxidants. Nat Prod Radiance. 5(4):326–334
go back to reference Gupta S, Droney T, Kyser A, Keller P (1999) Selegiline augmentation of antipsychotics for the treatment of negative symptoms in schizophrenia. Compr Psychiatry 40:148–150PubMedCrossRef Gupta S, Droney T, Kyser A, Keller P (1999) Selegiline augmentation of antipsychotics for the treatment of negative symptoms in schizophrenia. Compr Psychiatry 40:148–150PubMedCrossRef
go back to reference Gutteridge JMC (1995) Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun 19:141CrossRef Gutteridge JMC (1995) Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun 19:141CrossRef
go back to reference Harvey PD, Keefe RSE (2001) Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment. Am J Psychiatry 158:176–184PubMedCrossRef Harvey PD, Keefe RSE (2001) Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment. Am J Psychiatry 158:176–184PubMedCrossRef
go back to reference Hayashi T, Su TP (2004) Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 18(5):269–284PubMedCrossRef Hayashi T, Su TP (2004) Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 18(5):269–284PubMedCrossRef
go back to reference He J, Yang Y, Xu H, Zhang X, Li XM (2005) Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology 30(8):1511–1520PubMedCrossRef He J, Yang Y, Xu H, Zhang X, Li XM (2005) Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology 30(8):1511–1520PubMedCrossRef
go back to reference Hemish J, Nakaya N, Mittal V, Enikolopov G (2003) Nitric oxide activates diverse signaling pathways to regulate gene expression. J Biol Chem 278:42321–42329PubMedCrossRef Hemish J, Nakaya N, Mittal V, Enikolopov G (2003) Nitric oxide activates diverse signaling pathways to regulate gene expression. J Biol Chem 278:42321–42329PubMedCrossRef
go back to reference Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Horowitz A, Kelly D (1996) Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 169:610–617PubMedCrossRef Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Horowitz A, Kelly D (1996) Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 169:610–617PubMedCrossRef
go back to reference Hesslinger B, Normann C, Langosch JM, Klose P, Berger M, Walden J (1999) Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients. J Clin Psychopharmacol 19:310–315PubMedCrossRef Hesslinger B, Normann C, Langosch JM, Klose P, Berger M, Walden J (1999) Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients. J Clin Psychopharmacol 19:310–315PubMedCrossRef
go back to reference Hobbs AJ, Ignarro LJ (1996) Nitric oxide-cyclic GMP signal transduction system. Methods Enzymol 269:134–148PubMedCrossRef Hobbs AJ, Ignarro LJ (1996) Nitric oxide-cyclic GMP signal transduction system. Methods Enzymol 269:134–148PubMedCrossRef
go back to reference Hoffer A (1960) Adrenaline metabolites and schizophrenia. Dis Nerv Syst 21:79PubMed Hoffer A (1960) Adrenaline metabolites and schizophrenia. Dis Nerv Syst 21:79PubMed
go back to reference Hoffer A, Prousky J (2008) Successful treatment of schizophrenia requires optimal daily doses of vitamin B3. Altern Med Rev 13(4):287–291PubMed Hoffer A, Prousky J (2008) Successful treatment of schizophrenia requires optimal daily doses of vitamin B3. Altern Med Rev 13(4):287–291PubMed
go back to reference Hosak L, Libiger J (2002) Antiepileptic drugs in schizophrenia: a review. European psychiatry 17(7):371–378PubMedCrossRef Hosak L, Libiger J (2002) Antiepileptic drugs in schizophrenia: a review. European psychiatry 17(7):371–378PubMedCrossRef
go back to reference Hunter R (2014) Developing tomorrow’s antipsychotics: the need for a more personalised approach. Adv Psychiatr Treat 20(1):3–12CrossRef Hunter R (2014) Developing tomorrow’s antipsychotics: the need for a more personalised approach. Adv Psychiatr Treat 20(1):3–12CrossRef
go back to reference Idänpään-Heikkilä J, Alhava E, Olkinuora M, Palva IP (1977) Agranulocytosis during treatment with chlozapine. Eur J Clin Pharmacol 11(3):193–198PubMedCrossRef Idänpään-Heikkilä J, Alhava E, Olkinuora M, Palva IP (1977) Agranulocytosis during treatment with chlozapine. Eur J Clin Pharmacol 11(3):193–198PubMedCrossRef
go back to reference Insel TR (2010) Rethinking schizophrenia. Nature 468:187e93 Insel TR (2010) Rethinking schizophrenia. Nature 468:187e93
go back to reference Javitt DC, Zukin SR (1991) Recent advances in the phenciclidine model of schizophrenia. Am J Psychiatry 148:1301–1308PubMedCrossRef Javitt DC, Zukin SR (1991) Recent advances in the phenciclidine model of schizophrenia. Am J Psychiatry 148:1301–1308PubMedCrossRef
go back to reference Javitt DC, Silipo G, Cienfuegos A, Shelley AM, Bark N, Park M, Lindenmayer JP, Suckow R, Zukin SR (2001) Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol 4:385–391PubMedCrossRef Javitt DC, Silipo G, Cienfuegos A, Shelley AM, Bark N, Park M, Lindenmayer JP, Suckow R, Zukin SR (2001) Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol 4:385–391PubMedCrossRef
go back to reference Jones CK, Byun N, Bubser M (2012) Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. Neuropsychopharmacology 37(1):16–42PubMedCrossRef Jones CK, Byun N, Bubser M (2012) Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. Neuropsychopharmacology 37(1):16–42PubMedCrossRef
go back to reference Kapur S, Seeman P (2000) Antipsychotic agents differ in how fast they come off the dopamine D2 receptors: implications for atypical antipsychotic action. J Psychiatry Neurosci 25:161–166PubMedPubMedCentral Kapur S, Seeman P (2000) Antipsychotic agents differ in how fast they come off the dopamine D2 receptors: implications for atypical antipsychotic action. J Psychiatry Neurosci 25:161–166PubMedPubMedCentral
go back to reference Kasckow J, Nemeroff CB (1991) The neurobiology of neurotensin: focus on neurotensin–dopamine interactions. Regul Pept 36:153–164PubMedCrossRef Kasckow J, Nemeroff CB (1991) The neurobiology of neurotensin: focus on neurotensin–dopamine interactions. Regul Pept 36:153–164PubMedCrossRef
go back to reference Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261–276PubMedCrossRef Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261–276PubMedCrossRef
go back to reference Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, Hsiao JK, Lieberman JA, CATIE Investigators, Neurocognitive Working Group (2007) Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiatry 64(6):633–647PubMedCrossRef Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, Hsiao JK, Lieberman JA, CATIE Investigators, Neurocognitive Working Group (2007) Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiatry 64(6):633–647PubMedCrossRef
go back to reference King MV, Sleight AJ, Woolley ML, Topham IA, Marsden CA, Fone KC (2004) 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation—an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47(2):195–204PubMedCrossRef King MV, Sleight AJ, Woolley ML, Topham IA, Marsden CA, Fone KC (2004) 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation—an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47(2):195–204PubMedCrossRef
go back to reference Kirli S, Caliskan M (1998) A comparative study of sertraline versus imipramine in postpsychotic depressive disorder of schizophrenia. Schizophr Res 33:103–111PubMedCrossRef Kirli S, Caliskan M (1998) A comparative study of sertraline versus imipramine in postpsychotic depressive disorder of schizophrenia. Schizophr Res 33:103–111PubMedCrossRef
go back to reference Klein DF, Davis JM (1969) Diagnosis and drug treatment of psychiatric disorders. Krieger, Huntington Klein DF, Davis JM (1969) Diagnosis and drug treatment of psychiatric disorders. Krieger, Huntington
go back to reference Kontis D, Theochari E, Fryssira H, Kleisas S, Sofocleous C, Andreopoulou A, Kalogerakou S, Gazi A, Boniatsi L, Chaidemenos A, Tsaltas E (2013) COMT and polymorphisms interaction on cognition in schizophrenia: an exploratory study. Neurosci Lett 537:17–22PubMedCrossRef Kontis D, Theochari E, Fryssira H, Kleisas S, Sofocleous C, Andreopoulou A, Kalogerakou S, Gazi A, Boniatsi L, Chaidemenos A, Tsaltas E (2013) COMT and polymorphisms interaction on cognition in schizophrenia: an exploratory study. Neurosci Lett 537:17–22PubMedCrossRef
go back to reference Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519–526PubMedCrossRef Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519–526PubMedCrossRef
go back to reference Kroken RA, Loberg EM, Dronen T, Gruner R, Hugdahl K, Kompus K, Skrede S, Johnsen E (2014) A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation. Front Psychiatry 5:11PubMedPubMedCentralCrossRef Kroken RA, Loberg EM, Dronen T, Gruner R, Hugdahl K, Kompus K, Skrede S, Johnsen E (2014) A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation. Front Psychiatry 5:11PubMedPubMedCentralCrossRef
go back to reference Kuperberg G, Kerwin R, Murray R (2002) Developments in the pharmacological treatment of schizophrenia. Expert Opin Investig Drugs 11(10):1335–1341PubMedCrossRef Kuperberg G, Kerwin R, Murray R (2002) Developments in the pharmacological treatment of schizophrenia. Expert Opin Investig Drugs 11(10):1335–1341PubMedCrossRef
go back to reference Lambert P, Perrin J, Revol L et al (1959) Essai de classification des neuroleptiques d’après leurs activités psychopharmacologiques et cliniques. In: Bradley PB, Deniker P, Radouco-Thomas C (eds) Neuropsychopharmacology. Elsevier, Amsterdam, pp 619–624 Lambert P, Perrin J, Revol L et al (1959) Essai de classification des neuroleptiques d’après leurs activités psychopharmacologiques et cliniques. In: Bradley PB, Deniker P, Radouco-Thomas C (eds) Neuropsychopharmacology. Elsevier, Amsterdam, pp 619–624
go back to reference Large CH, Webster EL, Goff DC (2005) The potential role of lamotrigine in schizophrenia. Psychopharmacology 181(3):415–436PubMedCrossRef Large CH, Webster EL, Goff DC (2005) The potential role of lamotrigine in schizophrenia. Psychopharmacology 181(3):415–436PubMedCrossRef
go back to reference Laruelle M, Kegeles LS, Abi-Dargham A (2003) Glutamate, dopamine, and schizophrenia from pathophysiology to treatment. Ann NY Acad Sci 1003:138–158PubMedCrossRef Laruelle M, Kegeles LS, Abi-Dargham A (2003) Glutamate, dopamine, and schizophrenia from pathophysiology to treatment. Ann NY Acad Sci 1003:138–158PubMedCrossRef
go back to reference Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218–3226PubMed Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218–3226PubMed
go back to reference Liljequist R, Haapalinna A, Ahlander M, Li YH, Mannisto PT (1997) Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res 82:195–202PubMedCrossRef Liljequist R, Haapalinna A, Ahlander M, Li YH, Mannisto PT (1997) Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res 82:195–202PubMedCrossRef
go back to reference Lin A, Kenis G, Bignotti S, Tura GJ, De Jong R, Bosmans E, Pioli R, Altamura C, Scharpe S, Maes M (1998) The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6. Schizophr Res 32:9–15PubMedCrossRef Lin A, Kenis G, Bignotti S, Tura GJ, De Jong R, Bosmans E, Pioli R, Altamura C, Scharpe S, Maes M (1998) The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6. Schizophr Res 32:9–15PubMedCrossRef
go back to reference Litman RE, Su TP, Potter WZ, Hong WW, Pickar D (1996) Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia. Comparison with the atypical neuroleptic, clozapine. Br J Psychiatry 168:571–579PubMedCrossRef Litman RE, Su TP, Potter WZ, Hong WW, Pickar D (1996) Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia. Comparison with the atypical neuroleptic, clozapine. Br J Psychiatry 168:571–579PubMedCrossRef
go back to reference Madras BK (2013) History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia. J Hist Neurosci 22:62–78PubMedCrossRef Madras BK (2013) History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia. J Hist Neurosci 22:62–78PubMedCrossRef
go back to reference Manatt M, Chandra SB (2011) The effects of mitochondrial dysfunction in schizophrenia. J Med Genet Genomics 3(5):84–94 Manatt M, Chandra SB (2011) The effects of mitochondrial dysfunction in schizophrenia. J Med Genet Genomics 3(5):84–94
go back to reference Marazziti D, Baroni S, Picchetti M, Landi P, Silvestri S, Vatteroni E, Catena Dell’Osso M (2011) Mitochondrial alterations and neuropsychiatric disorders. Curr Med Chem 18:4715–4721PubMedCrossRef Marazziti D, Baroni S, Picchetti M, Landi P, Silvestri S, Vatteroni E, Catena Dell’Osso M (2011) Mitochondrial alterations and neuropsychiatric disorders. Curr Med Chem 18:4715–4721PubMedCrossRef
go back to reference Martin LF, Kem WR, Freedman R (2004) Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology 174:54–64PubMedCrossRef Martin LF, Kem WR, Freedman R (2004) Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology 174:54–64PubMedCrossRef
go back to reference Maurer I, Zierz S, Möller H (2001) Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia. Schizophren Res 48:125–136CrossRef Maurer I, Zierz S, Möller H (2001) Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia. Schizophren Res 48:125–136CrossRef
go back to reference Mayer B, Hemmens B (1997) Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 22:477–481PubMedCrossRef Mayer B, Hemmens B (1997) Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 22:477–481PubMedCrossRef
go back to reference Meiri KF, Saffell JL, Walsh FS, Doherty P (1998) Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones. J Neurosci 18:10429–10437PubMed Meiri KF, Saffell JL, Walsh FS, Doherty P (1998) Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones. J Neurosci 18:10429–10437PubMed
go back to reference Meltzer HY (1989) Clinical studies on the mechanism of action of clozapine—the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 99:S18–S27PubMedCrossRef Meltzer HY (1989) Clinical studies on the mechanism of action of clozapine—the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 99:S18–S27PubMedCrossRef
go back to reference Meltzer D (1999) Perspective and the measurement of costs and benefits for cost effectiveness analysis in schizophrenia. J Clin Psychiatry 60(Suppl 3):32–35 (discussion 36–7) PubMed Meltzer D (1999) Perspective and the measurement of costs and benefits for cost effectiveness analysis in schizophrenia. J Clin Psychiatry 60(Suppl 3):32–35 (discussion 36–7) PubMed
go back to reference Millan MJ, Schreiber R, Dekeyne A, Rivet JM, Bervoets K, Mavridis M, Sebban C, Maurel-Remy S, Newman-Tancredi A, Spedding M, Muller O, Lavielle G, Brocco M (1998) S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine and haloperidol. J Pharmacol Exp Ther 286(3):1356–1373PubMed Millan MJ, Schreiber R, Dekeyne A, Rivet JM, Bervoets K, Mavridis M, Sebban C, Maurel-Remy S, Newman-Tancredi A, Spedding M, Muller O, Lavielle G, Brocco M (1998) S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine and haloperidol. J Pharmacol Exp Ther 286(3):1356–1373PubMed
go back to reference Monji A, Kato T, Kanba S (2009) Cytokines and schizophrenia: microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci 63(3):257–265PubMedCrossRef Monji A, Kato T, Kanba S (2009) Cytokines and schizophrenia: microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci 63(3):257–265PubMedCrossRef
go back to reference Morris HM, Hashimoto T, Lewis DA (2008) Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb Cortex 18:1575–1587PubMedPubMedCentralCrossRef Morris HM, Hashimoto T, Lewis DA (2008) Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb Cortex 18:1575–1587PubMedPubMedCentralCrossRef
go back to reference Muller N, Schwarz MJ (2008) COX-2 inhibition in schizophrenia and major depression. Current pharmaceutical design 14(14):1452–1465PubMedCrossRef Muller N, Schwarz MJ (2008) COX-2 inhibition in schizophrenia and major depression. Current pharmaceutical design 14(14):1452–1465PubMedCrossRef
go back to reference Negre-Aminou P, Pfenninger KH (1993) Arachidonic acid turnover and phospholipase A2 activity in neuronal growth cones. J Neurochem 60:1126–1136PubMedCrossRef Negre-Aminou P, Pfenninger KH (1993) Arachidonic acid turnover and phospholipase A2 activity in neuronal growth cones. J Neurochem 60:1126–1136PubMedCrossRef
go back to reference Ng F, Berk M, Dean O, Bush AI (2008) Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11:851–876PubMedCrossRef Ng F, Berk M, Dean O, Bush AI (2008) Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11:851–876PubMedCrossRef
go back to reference Nissinen L, Kahari VM (2014) Matrix metalloproteinases in inflammation. Biochim Biophys Acta 1840:2571–2580PubMedCrossRef Nissinen L, Kahari VM (2014) Matrix metalloproteinases in inflammation. Biochim Biophys Acta 1840:2571–2580PubMedCrossRef
go back to reference Oliveira JP, Zuardi AW, Hallak JE (2008) Role of nitric oxide in patients with schizophrenia—a systematic review of the literature. Curr Psychiatry Rev 4:219–227CrossRef Oliveira JP, Zuardi AW, Hallak JE (2008) Role of nitric oxide in patients with schizophrenia—a systematic review of the literature. Curr Psychiatry Rev 4:219–227CrossRef
go back to reference Osmond H, Smythies J (1952) Schizophrenia: a new approach. J Ment Sci 98(411):309–315PubMed Osmond H, Smythies J (1952) Schizophrenia: a new approach. J Ment Sci 98(411):309–315PubMed
go back to reference Parle M, Kadian R (2013a) Behavioral models of psychosis. Int Res J Pharm 7:26–30CrossRef Parle M, Kadian R (2013a) Behavioral models of psychosis. Int Res J Pharm 7:26–30CrossRef
go back to reference Parle M, Kadian R (2013b) Non behavioral models of psychosis. Int Res J Pharm 4(8):89–95CrossRef Parle M, Kadian R (2013b) Non behavioral models of psychosis. Int Res J Pharm 4(8):89–95CrossRef
go back to reference Parle M, Sharma K (2013) Biomarker and causative factor of schizophrenia. Int Res J Pharm 4:78–85CrossRef Parle M, Sharma K (2013) Biomarker and causative factor of schizophrenia. Int Res J Pharm 4:78–85CrossRef
go back to reference Peet M, Brind J, Ramchand CN, Shah S, Vankar GK (2001) Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res 49:243–251PubMedCrossRef Peet M, Brind J, Ramchand CN, Shah S, Vankar GK (2001) Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res 49:243–251PubMedCrossRef
go back to reference Perenyi A, Goswami U, Frecska E, Arato M, Bela A (1992) l-Deprenyl in treating negative symptoms of schizophrenia. Psychiatry Res 42:189–191PubMedCrossRef Perenyi A, Goswami U, Frecska E, Arato M, Bela A (1992) l-Deprenyl in treating negative symptoms of schizophrenia. Psychiatry Res 42:189–191PubMedCrossRef
go back to reference Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83(1):84–92PubMedCrossRef Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83(1):84–92PubMedCrossRef
go back to reference Piletz JE, Chikkala DN, Ernsberger P (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha 2-adrenergic receptors. J Pharmacol Exp Ther 272:581–587PubMed Piletz JE, Chikkala DN, Ernsberger P (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha 2-adrenergic receptors. J Pharmacol Exp Ther 272:581–587PubMed
go back to reference Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC (1991) Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature 353:164–167PubMedCrossRef Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC (1991) Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature 353:164–167PubMedCrossRef
go back to reference Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, Charlton SJ, Tobin AB (2010) The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci USA 107:9440–9445PubMedPubMedCentralCrossRef Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, Charlton SJ, Tobin AB (2010) The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci USA 107:9440–9445PubMedPubMedCentralCrossRef
go back to reference Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JTJ, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S (2004) Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 9(684–97):643CrossRef Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JTJ, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S (2004) Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 9(684–97):643CrossRef
go back to reference Puzzo D, Sapienza S, Arancio O, Palmeri A (2008) Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 4(2):371–387PubMedPubMedCentralCrossRef Puzzo D, Sapienza S, Arancio O, Palmeri A (2008) Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 4(2):371–387PubMedPubMedCentralCrossRef
go back to reference Raiteri M, Leardi R, Marchi M (1984) Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J Pharmacol Exp Ther 228:209–214PubMed Raiteri M, Leardi R, Marchi M (1984) Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J Pharmacol Exp Ther 228:209–214PubMed
go back to reference Raiteri M, Marchi M, Paudice P, Pittaluga A (1990) Muscarinic receptors mediating inhibition of g-aminobutyric acid release in rat corpus striatum and their pharmacological characterization. J Pharmacol Exp Ther 254:496–501PubMed Raiteri M, Marchi M, Paudice P, Pittaluga A (1990) Muscarinic receptors mediating inhibition of g-aminobutyric acid release in rat corpus striatum and their pharmacological characterization. J Pharmacol Exp Ther 254:496–501PubMed
go back to reference Rajasekaran A, Venkatasubramanian G, Berk M, Debnath M (2015) Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications. Neurosci Biobehav Rev 48:10–21PubMedCrossRef Rajasekaran A, Venkatasubramanian G, Berk M, Debnath M (2015) Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications. Neurosci Biobehav Rev 48:10–21PubMedCrossRef
go back to reference Rao NP, Remington G (2013) Investigational drugs for schizophrenia targeting the dopamine receptor: phase II trials. Expert Opin Investig Drugs 22(7):881–894PubMedCrossRef Rao NP, Remington G (2013) Investigational drugs for schizophrenia targeting the dopamine receptor: phase II trials. Expert Opin Investig Drugs 22(7):881–894PubMedCrossRef
go back to reference Reznik I, Sirota P (2000) An open study of fluvoxamine augmentation of neuroleptics in schizophrenia with obsessive and compulsive symptoms. Clin Neuropharmacol 23(3):157–160PubMedCrossRef Reznik I, Sirota P (2000) An open study of fluvoxamine augmentation of neuroleptics in schizophrenia with obsessive and compulsive symptoms. Clin Neuropharmacol 23(3):157–160PubMedCrossRef
go back to reference Richardson AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18:155–172PubMedCrossRef Richardson AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18:155–172PubMedCrossRef
go back to reference Riecher-Rossler A, Hafner H (2000) Gender aspects in schizophrenia: bridging the border between social and biological psychiatry. Acta Psychiatr Scand Suppl 102:58–62CrossRef Riecher-Rossler A, Hafner H (2000) Gender aspects in schizophrenia: bridging the border between social and biological psychiatry. Acta Psychiatr Scand Suppl 102:58–62CrossRef
go back to reference Risch SC, McGurk S, Horner MD, Nahas Z, Owens SD, Molloy M, Gilliard C, Christie S, Markowitz JS, DeVane CL, Mintzer J, George MS (2001) A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates. Neurocase 7:105–110PubMedCrossRef Risch SC, McGurk S, Horner MD, Nahas Z, Owens SD, Molloy M, Gilliard C, Christie S, Markowitz JS, DeVane CL, Mintzer J, George MS (2001) A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates. Neurocase 7:105–110PubMedCrossRef
go back to reference Rogers DC, Hagan JJ (2001) 5-HT6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology 158(2):114–119PubMedCrossRef Rogers DC, Hagan JJ (2001) 5-HT6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology 158(2):114–119PubMedCrossRef
go back to reference Rosenberg GA (2009) Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 8:205–216PubMedCrossRef Rosenberg GA (2009) Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 8:205–216PubMedCrossRef
go back to reference Roth BL, Hanizavareh SM, Blum AE (2004) Serotonin receptors represent highly favourable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology 174:17–24PubMedCrossRef Roth BL, Hanizavareh SM, Blum AE (2004) Serotonin receptors represent highly favourable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology 174:17–24PubMedCrossRef
go back to reference Rouse ST, Edmunds SM, Yi H, Gilmor ML, Levey AI (2000) Localization of M(2) muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci Lett 284:182–186PubMedCrossRef Rouse ST, Edmunds SM, Yi H, Gilmor ML, Levey AI (2000) Localization of M(2) muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci Lett 284:182–186PubMedCrossRef
go back to reference Rubeša G, Gudelj L, Kubinska N (2011) Etiology of schizophrenia and therapeutic options. Psychiatr Danub. 23(3):308–315PubMed Rubeša G, Gudelj L, Kubinska N (2011) Etiology of schizophrenia and therapeutic options. Psychiatr Danub. 23(3):308–315PubMed
go back to reference Rukmini MS, D’Souza B, D’Souza V (2004) Superoxide dismutase and catalase activities and their correlation with malondialdehyde in schizophrenic patients. Indian J Clin Biochem 19(2):114–118PubMedPubMedCentralCrossRef Rukmini MS, D’Souza B, D’Souza V (2004) Superoxide dismutase and catalase activities and their correlation with malondialdehyde in schizophrenic patients. Indian J Clin Biochem 19(2):114–118PubMedPubMedCentralCrossRef
go back to reference Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lübbert H, Albuquerque EX, Maelicke A (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther 305(3):1024–1036PubMedCrossRef Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lübbert H, Albuquerque EX, Maelicke A (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther 305(3):1024–1036PubMedCrossRef
go back to reference Sarter M, Bruno JP (1997) Cognitive functions of cortical acetylcholine: toward a unifying hypothesis. Brain Res Brain Res Rev 23:28–46PubMedCrossRef Sarter M, Bruno JP (1997) Cognitive functions of cortical acetylcholine: toward a unifying hypothesis. Brain Res Brain Res Rev 23:28–46PubMedCrossRef
go back to reference Saudou F, Hen R (1994) 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 25(6):503–532PubMedCrossRef Saudou F, Hen R (1994) 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 25(6):503–532PubMedCrossRef
go back to reference Schmidt CJ, Chapin DS, Cianfrogna J, Corman ML, Hajos M, Harms JF, Hoffman WE, Lebel LA, McCarthy SA, Nelson FR, Proulx-LaFrance C, Majchrzak MJ, Ramirez AD, Schmidt K, Seymour PA, Siuciak JA, Tingley FD 3rd, Williams RD, Verhoest PR, Menniti FS (2008) Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia. J Pharmacol Exp Ther 325(2):681–690PubMedCrossRef Schmidt CJ, Chapin DS, Cianfrogna J, Corman ML, Hajos M, Harms JF, Hoffman WE, Lebel LA, McCarthy SA, Nelson FR, Proulx-LaFrance C, Majchrzak MJ, Ramirez AD, Schmidt K, Seymour PA, Siuciak JA, Tingley FD 3rd, Williams RD, Verhoest PR, Menniti FS (2008) Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia. J Pharmacol Exp Ther 325(2):681–690PubMedCrossRef
go back to reference Seeger TF, Bartlett B, Coskran TM, Culp JS, James LC, Krull DL, Lanfear J, Ryan AM, Schmidt CJ, Strick CA, Varghese AH, Williams RD, Wylie PG, Menniti FS (2003) Immunohistochemical localization of PDE10A in the rat brain. Brain Res 985:113–126PubMedCrossRef Seeger TF, Bartlett B, Coskran TM, Culp JS, James LC, Krull DL, Lanfear J, Ryan AM, Schmidt CJ, Strick CA, Varghese AH, Williams RD, Wylie PG, Menniti FS (2003) Immunohistochemical localization of PDE10A in the rat brain. Brain Res 985:113–126PubMedCrossRef
go back to reference Seeman P, Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neutrons. Science 188:1217–1219PubMedCrossRef Seeman P, Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neutrons. Science 188:1217–1219PubMedCrossRef
go back to reference Selvaraj S, Arnone D, Cappai A, Howes O (2014) Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies. Neurosci Biobehav Rev 45:233–245PubMedCrossRef Selvaraj S, Arnone D, Cappai A, Howes O (2014) Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies. Neurosci Biobehav Rev 45:233–245PubMedCrossRef
go back to reference Shekhawat LS, Jiloha RC (2009) Recent advances in the treatment of schizophrenia. Delhi Psych J 12(2):176–187 Shekhawat LS, Jiloha RC (2009) Recent advances in the treatment of schizophrenia. Delhi Psych J 12(2):176–187
go back to reference Siris SG, Bermanzohn PC, Mason SE, Shuwall MA (1994) Maintenance imipramine therapy for secondary depression in schizophrenia: a controlled trial. Arch Gen Psychiatry 51:109–115PubMedCrossRef Siris SG, Bermanzohn PC, Mason SE, Shuwall MA (1994) Maintenance imipramine therapy for secondary depression in schizophrenia: a controlled trial. Arch Gen Psychiatry 51:109–115PubMedCrossRef
go back to reference Siuciak JA, Chapin DS, Harms JF, Lebel LA, McCarthy SA, Chambers L, Shrikhande A, Wong S, Menniti FS, Schmidt CJ (2006) Inhibition of the striatum- enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis. Neuropharmacology 51:386–396PubMedCrossRef Siuciak JA, Chapin DS, Harms JF, Lebel LA, McCarthy SA, Chambers L, Shrikhande A, Wong S, Menniti FS, Schmidt CJ (2006) Inhibition of the striatum- enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis. Neuropharmacology 51:386–396PubMedCrossRef
go back to reference Skosnika PD, Yao JK (2003) From membrane phospholipid defects to altered neurotransmission: is arachidonic acid a nexus in the pathophysiology of schizophrenia? Prostaglandins Leukot Essent Fatty Acids 69:367–384CrossRef Skosnika PD, Yao JK (2003) From membrane phospholipid defects to altered neurotransmission: is arachidonic acid a nexus in the pathophysiology of schizophrenia? Prostaglandins Leukot Essent Fatty Acids 69:367–384CrossRef
go back to reference Snyder SH, Banerjee SP, Yamamura HI, Greenberg D (1974) Drugs, neurotransmitters, and schizophrenia. Science 184:1243–1253PubMedCrossRef Snyder SH, Banerjee SP, Yamamura HI, Greenberg D (1974) Drugs, neurotransmitters, and schizophrenia. Science 184:1243–1253PubMedCrossRef
go back to reference Sorenson EM, Shiroyama T, Kitai ST (1998) Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience 87:659–673PubMedCrossRef Sorenson EM, Shiroyama T, Kitai ST (1998) Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience 87:659–673PubMedCrossRef
go back to reference Spear N, Gadient RA, Wilkins DE, Do M, Smith JS, Zeller KL, Schroeder P, Zhang M, Arora J, Chhajlani V (2011) Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol 659:146–154PubMedCrossRef Spear N, Gadient RA, Wilkins DE, Do M, Smith JS, Zeller KL, Schroeder P, Zhang M, Arora J, Chhajlani V (2011) Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol 659:146–154PubMedCrossRef
go back to reference Spooren W, Riemer C, Meltzer H (2005) NK3 receptor antagonists: the next generation of antipsychotics? Nat Rev Drug Discov 4:967–975PubMedCrossRef Spooren W, Riemer C, Meltzer H (2005) NK3 receptor antagonists: the next generation of antipsychotics? Nat Rev Drug Discov 4:967–975PubMedCrossRef
go back to reference Steullet P, Cabungcal JH, Monin A, Dwir D, O’Donnell P, Cuenod M, Do KQ (2016) Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a “central hub” in schizophrenia pathophysiology? Schizophr Res 176(1):41–51PubMedCrossRef Steullet P, Cabungcal JH, Monin A, Dwir D, O’Donnell P, Cuenod M, Do KQ (2016) Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a “central hub” in schizophrenia pathophysiology? Schizophr Res 176(1):41–51PubMedCrossRef
go back to reference St-Gelais F, Menard C, Congar P, Trudeau LE, Massicotte G (2004) Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. Hippocampus 14:319–325PubMedCrossRef St-Gelais F, Menard C, Congar P, Trudeau LE, Massicotte G (2004) Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. Hippocampus 14:319–325PubMedCrossRef
go back to reference Tsai G, Coyle JT (2002) Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 42:165–179PubMedCrossRef Tsai G, Coyle JT (2002) Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 42:165–179PubMedCrossRef
go back to reference Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG (2003) Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8:673–679PubMedCrossRef Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG (2003) Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8:673–679PubMedCrossRef
go back to reference Tzavara ET, Bymaster FP, Davis RJ, Wade MR, Perry KW, Wess J, McKinzie DL, Felder C, Nomikos GG (2004) M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J 18:1410–1412PubMed Tzavara ET, Bymaster FP, Davis RJ, Wade MR, Perry KW, Wess J, McKinzie DL, Felder C, Nomikos GG (2004) M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J 18:1410–1412PubMed
go back to reference Ungvari GS, Chiu HF, Chow LY, Lau BS, Tang WK (1999) Lorazepam for chronic catatonia: a randomized, double blind, placebo-controlled cross-over study. Psychopharmacology 142:393–398PubMedCrossRef Ungvari GS, Chiu HF, Chow LY, Lau BS, Tang WK (1999) Lorazepam for chronic catatonia: a randomized, double blind, placebo-controlled cross-over study. Psychopharmacology 142:393–398PubMedCrossRef
go back to reference Uzbay IT, Kayir H, Göktalay G, Yildirim M (2008) Agmatine induces schizophrenia like-symptom in Wistar rats. Eur Neuropsychopharmacol 18(Suppl. 4):S399CrossRef Uzbay IT, Kayir H, Göktalay G, Yildirim M (2008) Agmatine induces schizophrenia like-symptom in Wistar rats. Eur Neuropsychopharmacol 18(Suppl. 4):S399CrossRef
go back to reference Vilaro MT, Palacios JM, Mengod G (1990) Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci Lett 114:154–159PubMedCrossRef Vilaro MT, Palacios JM, Mengod G (1990) Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci Lett 114:154–159PubMedCrossRef
go back to reference Vizi ES, Kobayashi O, Töröcsik A, Kinjo M, Nagashima H, Manabe N, Goldiner PL, Potter PE, Foldes FF (1989) Heterogeneity of presynaptic muscarinic receptors involved in modulation of transmitter release. Neuroscience 31:259–267PubMedCrossRef Vizi ES, Kobayashi O, Töröcsik A, Kinjo M, Nagashima H, Manabe N, Goldiner PL, Potter PE, Foldes FF (1989) Heterogeneity of presynaptic muscarinic receptors involved in modulation of transmitter release. Neuroscience 31:259–267PubMedCrossRef
go back to reference Vyas NS, Patel NH, Puri BK (2011) Neurobiology and phenotypic expression in early onset schizophrenia. Early Interv Psychiatry 5:3–14PubMedCrossRef Vyas NS, Patel NH, Puri BK (2011) Neurobiology and phenotypic expression in early onset schizophrenia. Early Interv Psychiatry 5:3–14PubMedCrossRef
go back to reference Wamsley JK, Zarbin MA, Kuhar MJ (1984) Distribution of muscarinic cholinergic high and low affinity agonist binding sites: a light microscopic autoradiographic study. Brain Res Bull 12:233–243PubMedCrossRef Wamsley JK, Zarbin MA, Kuhar MJ (1984) Distribution of muscarinic cholinergic high and low affinity agonist binding sites: a light microscopic autoradiographic study. Brain Res Bull 12:233–243PubMedCrossRef
go back to reference Wei J, Hemmings GP (1999) The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. Eur Psychiatry 14:67–70PubMedCrossRef Wei J, Hemmings GP (1999) The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. Eur Psychiatry 14:67–70PubMedCrossRef
go back to reference Weiner DM, Levey AI, Brann MR (1990) Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proc Natl Acad Sci USA 87:7050–7054PubMedPubMedCentralCrossRef Weiner DM, Levey AI, Brann MR (1990) Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proc Natl Acad Sci USA 87:7050–7054PubMedPubMedCentralCrossRef
go back to reference Wils RS, Gotfredsen DR, Hjorthøj C, Austin SF, Albert N, Secher RG, Thorup AA, Mors O, Nordentoft M (2016) Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. Schizophr Res (in press) Wils RS, Gotfredsen DR, Hjorthøj C, Austin SF, Albert N, Secher RG, Thorup AA, Mors O, Nordentoft M (2016) Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. Schizophr Res (in press)
go back to reference Wolkowitz OM, Pickar D (1991) Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry 148:714–726PubMedCrossRef Wolkowitz OM, Pickar D (1991) Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry 148:714–726PubMedCrossRef
go back to reference Xie Z, Adamowicz WO, Eldred WD, Jakowski AB, Kleiman RJ, Morton DG, Stephenson DT, Strick CA, Williams RD, Menniti FS (2006) Cellular and subcellular localization of PDE10A, a striatal-specific phosphodiesterase. Neuroscience 139:597–607PubMedPubMedCentralCrossRef Xie Z, Adamowicz WO, Eldred WD, Jakowski AB, Kleiman RJ, Morton DG, Stephenson DT, Strick CA, Williams RD, Menniti FS (2006) Cellular and subcellular localization of PDE10A, a striatal-specific phosphodiesterase. Neuroscience 139:597–607PubMedPubMedCentralCrossRef
go back to reference Yadav M, Parle M, Kadian M, Sharma K (2015) A review on psychosis and anti-psychotic plants. Asian J Pharm Clin Res 8(4):24–28 Yadav M, Parle M, Kadian M, Sharma K (2015) A review on psychosis and anti-psychotic plants. Asian J Pharm Clin Res 8(4):24–28
go back to reference Yoshida K, Higuchi H, Hishikawa Y (1998) Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient. Clin Neuropharmacol 21(1):68–69PubMed Yoshida K, Higuchi H, Hishikawa Y (1998) Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient. Clin Neuropharmacol 21(1):68–69PubMed
go back to reference Zang Z, Creese I (1997) Differential regulation of expression of rat hippocampal muscarinic receptor subtypes following fimbria–fornix lesion. Biochem Pharmacol 53:1379–1382PubMedCrossRef Zang Z, Creese I (1997) Differential regulation of expression of rat hippocampal muscarinic receptor subtypes following fimbria–fornix lesion. Biochem Pharmacol 53:1379–1382PubMedCrossRef
go back to reference Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J (2002) Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knockout mice. J Neurosci 22:1709–1717PubMed Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J (2002) Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knockout mice. J Neurosci 22:1709–1717PubMed
go back to reference Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY (2003) Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms. J Psychiatr Res 117:85–88CrossRef Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY (2003) Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms. J Psychiatr Res 117:85–88CrossRef
go back to reference Ziimmer R, Teelken AW, Cramer H, Ackenheil M, Zandler KJ, Fischer H (1980) Short- and long-term effects on GABA and dopamine neurons during treatment with sulpiride. Adv Biochem Psychopharmacol 24:537–539 Ziimmer R, Teelken AW, Cramer H, Ackenheil M, Zandler KJ, Fischer H (1980) Short- and long-term effects on GABA and dopamine neurons during treatment with sulpiride. Adv Biochem Psychopharmacol 24:537–539
Metadata
Title
Potential drug targets and treatment of schizophrenia
Authors
Anil Kumar
Monu Yadav
Milind Parle
Sameer Dhingra
Dinesh K. Dhull
Publication date
01-06-2017
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 3/2017
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-017-0340-5

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