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Published in: Inflammopharmacology 5/2011

01-10-2011 | Review

A review of the pharmacological effects of Arctium lappa (burdock)

Authors: Yuk-Shing Chan, Long-Ni Cheng, Jian-Hong Wu, Enoch Chan, Yiu-Wa Kwan, Simon Ming-Yuen Lee, George Pak-Heng Leung, Peter Hoi-Fu Yu, Shun-Wan Chan

Published in: Inflammopharmacology | Issue 5/2011

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Abstract

Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in traditional Chinese medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to “detoxify” blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and antidiabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects and potent inhibitory effects on the growth of tumors such as pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases such as cancers, diabetes and AIDS have been reported. However, it is also essential to be aware of the side effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock.
Literature
go back to reference Abreu P, Matthew S, Gonzalez T et al (2006) Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. Life Sci 78:1578–1585PubMedCrossRef Abreu P, Matthew S, Gonzalez T et al (2006) Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. Life Sci 78:1578–1585PubMedCrossRef
go back to reference Awale S, Lu J, Kalauni SK et al (2006) Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res 66:1751–1757PubMedCrossRef Awale S, Lu J, Kalauni SK et al (2006) Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res 66:1751–1757PubMedCrossRef
go back to reference Bhat SH, Azmi AS, Hadi SM (2007) Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharm 218:249–255CrossRef Bhat SH, Azmi AS, Hadi SM (2007) Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharm 218:249–255CrossRef
go back to reference Bouayed J, Rammal H, Dicko A et al (2007) Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 262:77–84PubMedCrossRef Bouayed J, Rammal H, Dicko A et al (2007) Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 262:77–84PubMedCrossRef
go back to reference Bralley E, Greenspan P, Hargrove JL et al (2008) Inhibition of hyaluronidase activity by select sorghum brans. J Med Food 11:307–312PubMedCrossRef Bralley E, Greenspan P, Hargrove JL et al (2008) Inhibition of hyaluronidase activity by select sorghum brans. J Med Food 11:307–312PubMedCrossRef
go back to reference Chan E, Wong CYK, Wan CW et al (2010) Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. Am J Chinese Med 38:815–827CrossRef Chan E, Wong CYK, Wan CW et al (2010) Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. Am J Chinese Med 38:815–827CrossRef
go back to reference Chen FA, Wu AB, Chen CY (2004) The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components. Food Chem 86:479–484CrossRef Chen FA, Wu AB, Chen CY (2004) The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components. Food Chem 86:479–484CrossRef
go back to reference Chiang LC, Chiang W, Chang MY et al (2002) Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Res 55:53–62PubMedCrossRef Chiang LC, Chiang W, Chang MY et al (2002) Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Res 55:53–62PubMedCrossRef
go back to reference Cho MK, Park JW, Jang YP et al (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappa B alpha phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol 2:105–116PubMedCrossRef Cho MK, Park JW, Jang YP et al (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappa B alpha phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol 2:105–116PubMedCrossRef
go back to reference Cho MK, Jang YP, Kim YC et al (2004) Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. Int Immunopharmacol 4:1419–1429PubMedCrossRef Cho MK, Jang YP, Kim YC et al (2004) Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. Int Immunopharmacol 4:1419–1429PubMedCrossRef
go back to reference Eich E, Pertz H, Kaloga M et al (1996) (−)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. J Med Chem 39:86–95PubMedCrossRef Eich E, Pertz H, Kaloga M et al (1996) (−)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. J Med Chem 39:86–95PubMedCrossRef
go back to reference Gao Y, Dong X, Kang TG et al (2002) Activity of in vitro anti-influenza virus of arctigenin. Chin Trad Herbal Drugs 33:724–726 Gao Y, Dong X, Kang TG et al (2002) Activity of in vitro anti-influenza virus of arctigenin. Chin Trad Herbal Drugs 33:724–726
go back to reference Guo JF, Zhou JM, Zhang Y et al (2008) Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Cell Biol Int 32:48–54PubMedCrossRef Guo JF, Zhou JM, Zhang Y et al (2008) Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Cell Biol Int 32:48–54PubMedCrossRef
go back to reference Hirose M, Yamaguchi T, Lin C et al (2000) Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague–Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett 155:79–88PubMedCrossRef Hirose M, Yamaguchi T, Lin C et al (2000) Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague–Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett 155:79–88PubMedCrossRef
go back to reference Ichikawa K, Kinoshita T, Nishibe S et al (1986) The Ca-2+ antagonist activity of lignans. Chem Pharm Bull 34:3514–3517PubMed Ichikawa K, Kinoshita T, Nishibe S et al (1986) The Ca-2+ antagonist activity of lignans. Chem Pharm Bull 34:3514–3517PubMed
go back to reference Ishihara K, Yamagishi N, Saito Y et al (2006) Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells. Cell Stress Chaperon 11:154–161CrossRef Ishihara K, Yamagishi N, Saito Y et al (2006) Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells. Cell Stress Chaperon 11:154–161CrossRef
go back to reference Iwakami S, Wu JB, Ebizuka Y et al (1992) Platelet activating factor (Paf) antagonists contained in medicinal-plants—lignans and sesquiterpenes. Chem Pharm Bull 40:1196–1198PubMed Iwakami S, Wu JB, Ebizuka Y et al (1992) Platelet activating factor (Paf) antagonists contained in medicinal-plants—lignans and sesquiterpenes. Chem Pharm Bull 40:1196–1198PubMed
go back to reference Kim BH, Hong SS, Kwon SW et al (2008) Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of dna binding ability of nuclear factor-kappa B in macrophages. J Pharmacol Exp Ther 327:393–401PubMedCrossRef Kim BH, Hong SS, Kwon SW et al (2008) Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of dna binding ability of nuclear factor-kappa B in macrophages. J Pharmacol Exp Ther 327:393–401PubMedCrossRef
go back to reference Knipping K, van Esch E, Wijering SC et al (2008) In Vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood) 233:1469CrossRef Knipping K, van Esch E, Wijering SC et al (2008) In Vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood) 233:1469CrossRef
go back to reference Lee CP, Shih PH, Hsu CL et al (2007) Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol 45:888–895PubMedCrossRef Lee CP, Shih PH, Hsu CL et al (2007) Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol 45:888–895PubMedCrossRef
go back to reference Li YJ, Liu SM, Li SL et al (2004) The experimental study of the effect of anti-decrepitude of Arctium lappa L. 15:545–546 Li YJ, Liu SM, Li SL et al (2004) The experimental study of the effect of anti-decrepitude of Arctium lappa L. 15:545–546
go back to reference Li YJ, Shi W, Li YD et al (2008) Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environ Toxicol Phar 26:13–21CrossRef Li YJ, Shi W, Li YD et al (2008) Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environ Toxicol Phar 26:13–21CrossRef
go back to reference Lin CC, Lin JM, Yang JJ et al (1996) Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med 24:127–137PubMedCrossRef Lin CC, Lin JM, Yang JJ et al (1996) Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med 24:127–137PubMedCrossRef
go back to reference Lin SC, Chung TC, Lin CC et al (2000) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med 28:163–173PubMedCrossRef Lin SC, Chung TC, Lin CC et al (2000) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med 28:163–173PubMedCrossRef
go back to reference Lin SC, Lin CH, Lin CC et al (2002) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci 9:401–409PubMed Lin SC, Lin CH, Lin CC et al (2002) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci 9:401–409PubMed
go back to reference Lin XC, Liu CY, Chen KS et al (2004) Extraction and content comparison of chlorogenic acid in Arctium lappa L. leaves collected from different terrain and its restraining bacteria test. Nat Prod Res Dev 16:328–330 Lin XC, Liu CY, Chen KS et al (2004) Extraction and content comparison of chlorogenic acid in Arctium lappa L. leaves collected from different terrain and its restraining bacteria test. Nat Prod Res Dev 16:328–330
go back to reference Liu L, Tang L (1997) Studies on antimutagenicity of burdock. Acta Academiae Medicine Nanjing 4:343–345 Liu L, Tang L (1997) Studies on antimutagenicity of burdock. Acta Academiae Medicine Nanjing 4:343–345
go back to reference Matsumoto T, Hosono-Nishiyama K, Yamada H (2006) Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med 72:276–278PubMedCrossRef Matsumoto T, Hosono-Nishiyama K, Yamada H (2006) Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med 72:276–278PubMedCrossRef
go back to reference Mitsuo M, Nobuo Y, Katsuya T (2005) Inhibitory compounds of alpha glucosidase activity from Arctium lappa L. J Oleo Sci 54:589–594CrossRef Mitsuo M, Nobuo Y, Katsuya T (2005) Inhibitory compounds of alpha glucosidase activity from Arctium lappa L. J Oleo Sci 54:589–594CrossRef
go back to reference Miyamoto K, Nomura M, Sasakura M et al (1993) Antitumor-activity of oenothein-B, a unique macrocyclic ellagitannin. Jpn J Cancer Res 84:99–103PubMed Miyamoto K, Nomura M, Sasakura M et al (1993) Antitumor-activity of oenothein-B, a unique macrocyclic ellagitannin. Jpn J Cancer Res 84:99–103PubMed
go back to reference Mizushina Y, Nakanishi R, Kuriyama I et al (2006) Beta-sitosterol-3-O-beta-d-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor. J Steroid Biochem 99:100–107CrossRef Mizushina Y, Nakanishi R, Kuriyama I et al (2006) Beta-sitosterol-3-O-beta-d-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor. J Steroid Biochem 99:100–107CrossRef
go back to reference Morita T, Ebihara K, Kiriyama S (1993) Dietary fiber and fat-derivatives prevent mineral-oil toxicity in rats by the same mechanism. J Nutr 123:1575–1585PubMed Morita T, Ebihara K, Kiriyama S (1993) Dietary fiber and fat-derivatives prevent mineral-oil toxicity in rats by the same mechanism. J Nutr 123:1575–1585PubMed
go back to reference Niggemann B, Gruber C (2003) Side-effects of complementary and alternative medicine. Allergy 58:707–716PubMedCrossRef Niggemann B, Gruber C (2003) Side-effects of complementary and alternative medicine. Allergy 58:707–716PubMedCrossRef
go back to reference Pari L, Prasath A (2008) Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chem Biol Interact 173:77–83PubMedCrossRef Pari L, Prasath A (2008) Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chem Biol Interact 173:77–83PubMedCrossRef
go back to reference Park SY, Hong SS, Han XH et al (2007) Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production. Chem Pharm Bull 55:150–152PubMedCrossRef Park SY, Hong SS, Han XH et al (2007) Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production. Chem Pharm Bull 55:150–152PubMedCrossRef
go back to reference Paulsen E (2002) Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 47:189–198PubMedCrossRef Paulsen E (2002) Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 47:189–198PubMedCrossRef
go back to reference Pereira JV, Bergamo DC, Pereira JO et al (2005) Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections. Braz Dent J 16:192–196PubMed Pereira JV, Bergamo DC, Pereira JO et al (2005) Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections. Braz Dent J 16:192–196PubMed
go back to reference Pontiki E, Hadjipavlou-Litina D, Chaviara AT et al (2006) Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline. Bioorg Med Chem Lett 16:2234–2237PubMedCrossRef Pontiki E, Hadjipavlou-Litina D, Chaviara AT et al (2006) Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline. Bioorg Med Chem Lett 16:2234–2237PubMedCrossRef
go back to reference Rault-Nania MH, Demougeot C, Gueux E et al (2008) Inulin supplementation prevents high fructose diet-induced hypertension in rats. Clin Nutr 27:276–282PubMedCrossRef Rault-Nania MH, Demougeot C, Gueux E et al (2008) Inulin supplementation prevents high fructose diet-induced hypertension in rats. Clin Nutr 27:276–282PubMedCrossRef
go back to reference Schroder HC, Merz H, Steffen R et al (1990) Differential in vitro anti-HIV activity of natural lignans. Z Naturforsch C 45:1215–1221PubMed Schroder HC, Merz H, Steffen R et al (1990) Differential in vitro anti-HIV activity of natural lignans. Z Naturforsch C 45:1215–1221PubMed
go back to reference Silver AA, Krantz JC Jr (1931) The effect of the ingestion of burdock root on normal and diabetic individuals: a preliminary report. Ann Intern Med 5:274 Silver AA, Krantz JC Jr (1931) The effect of the ingestion of burdock root on normal and diabetic individuals: a preliminary report. Ann Intern Med 5:274
go back to reference Takasaki M, Konoshima T, Komatsu K et al (2000) Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Lett 158:53–59PubMedCrossRef Takasaki M, Konoshima T, Komatsu K et al (2000) Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Lett 158:53–59PubMedCrossRef
go back to reference Takasugi M, Kawashima S, Katsui N et al (1987) Studies on stress metabolites. 5. 2 Polyacetylenic phytoalexins from Arctium lappa. Phytochemistry 26:2957–2958CrossRef Takasugi M, Kawashima S, Katsui N et al (1987) Studies on stress metabolites. 5. 2 Polyacetylenic phytoalexins from Arctium lappa. Phytochemistry 26:2957–2958CrossRef
go back to reference Tamayo C, Richardson MA, Diamond S et al (2000) The chemistry and biological activity of herbs used in Flor-Essence (TM) herbal tonic and Essiac (TM). Phytother Res 14:1–14PubMedCrossRef Tamayo C, Richardson MA, Diamond S et al (2000) The chemistry and biological activity of herbs used in Flor-Essence (TM) herbal tonic and Essiac (TM). Phytother Res 14:1–14PubMedCrossRef
go back to reference Tsuneki H, Ma EL, Kobayashi S et al (2005) Antiangiogenic activity of beta-eudesmol in vitro and in vivo. Eur J Pharmacol 512:105–115PubMedCrossRef Tsuneki H, Ma EL, Kobayashi S et al (2005) Antiangiogenic activity of beta-eudesmol in vitro and in vivo. Eur J Pharmacol 512:105–115PubMedCrossRef
go back to reference Wang BS, Yen GC, Chang LW et al (2007) Protective effects of burdock (Arctium lappa Linne) on oxidation of low-density lipoprotein and oxidative stress in RAW 264.7 macrophages. Food Chem 101:729–738CrossRef Wang BS, Yen GC, Chang LW et al (2007) Protective effects of burdock (Arctium lappa Linne) on oxidation of low-density lipoprotein and oxidative stress in RAW 264.7 macrophages. Food Chem 101:729–738CrossRef
go back to reference Weber V, Rubat C, Duroux E et al (2005) New 3-and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents. Bioorg Med Chem 13:4552–4564PubMedCrossRef Weber V, Rubat C, Duroux E et al (2005) New 3-and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents. Bioorg Med Chem 13:4552–4564PubMedCrossRef
go back to reference Xia ZQ, Costa MA, Pelissier HC et al (2001) Secoisolariciresinol dehydrogenase purification, cloning, and functional expression–implications for human health protection. J Biol Chem 276:12614–12623PubMedCrossRef Xia ZQ, Costa MA, Pelissier HC et al (2001) Secoisolariciresinol dehydrogenase purification, cloning, and functional expression–implications for human health protection. J Biol Chem 276:12614–12623PubMedCrossRef
go back to reference Xu ZH, Wang XY, Zhou MM et al (2008) The antidiabetic activity of total lignan from fructus arctii against alloxan-induced diabetes in mice and rats. Phytother Res 22:97–101PubMedCrossRef Xu ZH, Wang XY, Zhou MM et al (2008) The antidiabetic activity of total lignan from fructus arctii against alloxan-induced diabetes in mice and rats. Phytother Res 22:97–101PubMedCrossRef
go back to reference Yayli N, Yasar A, Gulec C et al (2005) Composition and antimicrobial activity of essential oils from Centaurea sessilis and Centaurea armena. Phytochemistry 66:1741–1745PubMedCrossRef Yayli N, Yasar A, Gulec C et al (2005) Composition and antimicrobial activity of essential oils from Centaurea sessilis and Centaurea armena. Phytochemistry 66:1741–1745PubMedCrossRef
go back to reference Yu BS, Yan XP, Xiong JY et al (2003) Simultaneous determination of chlorogenic acid, forsythin and arctiin in Chinese traditional medicines preparation by reversed phase-HPLC. Chem Pharm Bull 51:421–424PubMedCrossRef Yu BS, Yan XP, Xiong JY et al (2003) Simultaneous determination of chlorogenic acid, forsythin and arctiin in Chinese traditional medicines preparation by reversed phase-HPLC. Chem Pharm Bull 51:421–424PubMedCrossRef
go back to reference Zhao F, Wang L, Liu K (2009) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J. Ethnopharmacol 122:457–462CrossRef Zhao F, Wang L, Liu K (2009) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J. Ethnopharmacol 122:457–462CrossRef
Metadata
Title
A review of the pharmacological effects of Arctium lappa (burdock)
Authors
Yuk-Shing Chan
Long-Ni Cheng
Jian-Hong Wu
Enoch Chan
Yiu-Wa Kwan
Simon Ming-Yuen Lee
George Pak-Heng Leung
Peter Hoi-Fu Yu
Shun-Wan Chan
Publication date
01-10-2011
Publisher
SP Birkhäuser Verlag Basel
Published in
Inflammopharmacology / Issue 5/2011
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-010-0062-4

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