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Published in: Familial Cancer 3/2022

28-10-2021 | Parotid Gland Tumor | Correction

Correction to: Outcomes of retesting in patients with previously uninformative cancer genetics evaluations

Authors: Shenin A. Dettwyler, Erika S. Koeppe, Michelle F. Jacobs, Elena M. Stoffel

Published in: Familial Cancer | Issue 3/2022

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Excerpt

In Table 4 of the article “Outcomes of retesting in patients with previously uninformative cancer genetics evaluations” Authored by “Shenin A. Dettwyler, Erika S. Koeppe, Michelle F. Jacobs, Elena M. Stoffel, the data in the “Retest PV,” “Retest VUS, “and “Retest Negative “ columns do not align properly with the types of cancer in the first column. The correct Table 4 has been provided below.
Table 4
Cancer diagnoses and non-malignant manifestations in affected patients (n = 104)
 
Retest PV, n = 21 (20.2%)
Retest VUS, n = 10 (9.6%)
Retest negative, n = 73 (70.2%)
pa
Mean age at first diagnosis; years, (range)
Total: 42.5 (2–73)
38.9 (11–73)
35.8 (5–53)
44.5 (2–69)
0.26
 ≥ 2 primary diagnoses
Total: n = 42 (40.4%)
8 (19%)
6 (14.3%)
28 (66.7%)
0.10
Cancer type/non-malignant manifestationb,c
 
Female breast (n = 42, 40.4%)
8 (19%)
3 (7.1%)
31 (73.8%)
 
Melanoma (n = 27, 26%)
3 (11.1%)
2 (7.4%)
22 (81.5%)
Colorectal (n = 21, 20.2%)
2 (9.5%)
3 (14.3%)
16 (76.2%)
Otherd (n = 12, 11.5%)
4 (33.3%)
2 (16.7%)
5 (41.7%)
Sarcoma (n = 10, 9.6%)
3 (30%)
0
7 (70%)
PGL/PCC (n = 9, 8.7%)
2 (22.2%)
1 (11.1%)
6 (66.7%)
Thyroid (n = 8, 7.7%)
1 (12.5%)
1 (12.5%)
6 (75%)
Endometrial (n = 6, 5.8%)
2 (33.3%)
0
4 (66.7%)
 > 0.05
Ovarian (n = 5, 4.8%)
2 (40%)
2 (40%)
1 (20%)
 
Polyposise (n = 5, 4.8%)
3 (60%)
0
2 (40%)
Genitourinary (n = 3, 2.9%)
0
0
3 (100%)
Leukemia (n = 3, 2.9%)
0
0
3 (100%)
ACC (n = 3, 2.9%)
0
0
3 (100%)
Oral SCC (n = 2, 1.9%)
2 (100%)
0
0
Brain (n = 2, 1.9%)
1 (50%)
1 (50%)
0
HL (n = 2, 1.9%)
1 (50%)
1 (50%)
0
Hypercalcemia (n = 2, 1.9%)
1 (50%)
1 (50%)
0
Male breast (n = 2, 1.9%)
0
0
2 (100%)
Prostate (n = 2, 1.9%)
0
0
2 (100%)
Lung (n = 2, 1.9%)
0
0
2 (100%)
ACC, adrenocortical carcinoma; HL, Hodgkin’s lymphoma; PGL/PCC, paraganglioma or pheochromocytoma; SCC, squamous cell carcinoma
aCompared informative (positive) results to uninformative results (VUS and negative results collectively)
bIncludes non-malignant tumors associated with hereditary cancer predisposition syndromes and individuals with a clinical diagnosis of a hereditary cancer predisposition syndrome
cTotal n > 104 and > 100%, as n = 42 had multiple primary cancers/non-malignant manifestations. Additional diagnoses of non-melanoma skin cancers alone were excluded
d“Other” encompasses any cancer/non-malignant manifestation only observed once. Retest PV: gastrinoma, pancreatic neuroendocrine tumor, and primary hyperparathyroidism (n = 1 each, all in same patient); peritoneal mesothelioma (n = 1). Retest VUS: ovarian granulosa cell tumor, retinal hemangioblastoma (n = 1 each). Retest negative: bilateral acoustic neuromas, small bowel carcinoid, parotid gland tumor, sebaceous neoplasm; pancreatic (n = 1 each)
eClinical diagnosis of a hereditary polyposis syndrome. Retest PV: Familial Adenomatous Polyposis (n = 2) and Peutz-Jeghers syndrome (n = 1). Retest negative: Familial Adenomatous Polyposis and Juvenile Polyposis syndrome (n = 1 each)
Metadata
Title
Correction to: Outcomes of retesting in patients with previously uninformative cancer genetics evaluations
Authors
Shenin A. Dettwyler
Erika S. Koeppe
Michelle F. Jacobs
Elena M. Stoffel
Publication date
28-10-2021
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 3/2022
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-021-00279-5

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