Skip to main content
Top
Published in: Familial Cancer 2/2018

Open Access 01-04-2018 | Short Communication

A new hereditary colorectal cancer network in the Middle East and eastern mediterranean countries to improve care for high-risk families

Authors: Zeinab Ghorbanoghli, Carol Jabari, Walid Sweidan, Wail Hammoudeh, George Cortas, Ala I. Sharara, Amal Abedrabbo, Ijad Hourani, Bahareh Mahjoubi, Keivan Majidzadeh, Nurdan Tözün, Hadia Ziada-Bouchaar, Waseem Hamoudi, Osama Diab, Hamid Reza Khorram Khorshid, Henry Lynch, Hans Vasen

Published in: Familial Cancer | Issue 2/2018

Login to get access

Abstract

Colorectal cancer (CRC) has a very high incidence in the western world. Data from registries in the Middle East showed that the incidence of CRC is relatively low in these countries. However, these data also showed that CRC incidence has increased substantially over the past three decades and that a high proportion of cases are diagnosed at an early age (<50 years). In view of these findings, more attention should be paid to prevention. Because of the often limited financial resources, focused screening of individuals with hereditary CRC, in particular those with Lynch syndrome, appears to be the most cost-effective strategy. During recent meetings of the Palestinian Society of Gastroenterology and the Mediterranean Task force for Cancer Control (MTCC) in Jericho, and the Patient’s Friends Society of Jerusalem in Hebron the issue of hereditary CRC in the Middle East was discussed and the idea was conceived to establish a network on hereditary colorectal cancer (HCCN-ME) with the goal of improving care for high-risk groups in the Middle East and (Eastern) Mediterranean Countries.
Literature
4.
go back to reference Ziada-Bouchaar H, Sifi K, Filali T, Hammada T, Satta D, Abadi N (2017) First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome. Fam Cancer 16(1):57–66. doi:10.1007/s10689-016-9917-1 CrossRefPubMed Ziada-Bouchaar H, Sifi K, Filali T, Hammada T, Satta D, Abadi N (2017) First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome. Fam Cancer 16(1):57–66. doi:10.​1007/​s10689-016-9917-1 CrossRefPubMed
5.
go back to reference Soliman AS, Bondy ML, Levin B, El-Badawy S, Khaled H, Hablas A, Ismail S, Adly M, Mahgoub KG, McPherson RS, Beasley RP (1998) Familial aggregation of colorectal cancer in Egypt. Int J Cancer 77(6):811–816CrossRefPubMed Soliman AS, Bondy ML, Levin B, El-Badawy S, Khaled H, Hablas A, Ismail S, Adly M, Mahgoub KG, McPherson RS, Beasley RP (1998) Familial aggregation of colorectal cancer in Egypt. Int J Cancer 77(6):811–816CrossRefPubMed
6.
go back to reference Alqahtani M, Grieu F, Carrello A, Amanuel B, Mashour M, Alattas R, Alsaleh K, Alsheikh A, Alqahtani S, Iacopetta B (2016) Screening for Lynch syndrome in young colorectal cancer patients from Saudi Arabia using microsatellite instability as the initial test. Asian Pac J Cancer Prev 17(4):1917–1923CrossRefPubMed Alqahtani M, Grieu F, Carrello A, Amanuel B, Mashour M, Alattas R, Alsaleh K, Alsheikh A, Alqahtani S, Iacopetta B (2016) Screening for Lynch syndrome in young colorectal cancer patients from Saudi Arabia using microsatellite instability as the initial test. Asian Pac J Cancer Prev 17(4):1917–1923CrossRefPubMed
7.
go back to reference Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS (2015) Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer. Cancer 121(11):1762–1771. doi:10.1002/cncr.29288 CrossRefPubMed Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS (2015) Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer. Cancer 121(11):1762–1771. doi:10.​1002/​cncr.​29288 CrossRefPubMed
8.
go back to reference Shpitz B, Millman M, Ziv Y, Klein E, Grankin M, Gochberg S, Sandbank J, Halevi A, Bernheim J, Khromov Y, Gutman M, Sayfan J (2006) Predominance of younger age, advanced stage, poorly-differentiated and mucinous histology in Israeli Arab patients with colorectal cancer. Anticancer Res 26(1B):533–537PubMed Shpitz B, Millman M, Ziv Y, Klein E, Grankin M, Gochberg S, Sandbank J, Halevi A, Bernheim J, Khromov Y, Gutman M, Sayfan J (2006) Predominance of younger age, advanced stage, poorly-differentiated and mucinous histology in Israeli Arab patients with colorectal cancer. Anticancer Res 26(1B):533–537PubMed
9.
go back to reference Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116(6):1453–1456CrossRefPubMed Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116(6):1453–1456CrossRefPubMed
11.
go back to reference Hechtman JF, Middha S, Stadler ZK, Zehir A, Berger MF, Vakiani E, Weiser MR, Ladanyi M, Saltz LB, Klimstra DS, Shia J (2017) Universal screening for microsatellite instability in colorectal cancer in the clinical genomics era: new recommendations, methods, and considerations. Fam Cancer. doi:10.1007/s10689-017-9993-x Hechtman JF, Middha S, Stadler ZK, Zehir A, Berger MF, Vakiani E, Weiser MR, Ladanyi M, Saltz LB, Klimstra DS, Shia J (2017) Universal screening for microsatellite instability in colorectal cancer in the clinical genomics era: new recommendations, methods, and considerations. Fam Cancer. doi:10.​1007/​s10689-017-9993-x
12.
go back to reference Vasen HF, Ghorbanoghli Z, Bourdeaut F, Cabaret O, Caron O, Duval A, Entz-Werle N, Goldberg Y, Ilencikova D, Kratz CP, Lavoine N, Loeffen J, Menko FH, Muleris M, Sebille G, Colas C, Burkhardt B, Brugieres L, Wimmer K (2014) Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium “Care for CMMR-D” (C4CMMR-D). J Med Genet 51(5):283–293. doi:10.1136/jmedgenet-2013-102238 CrossRefPubMed Vasen HF, Ghorbanoghli Z, Bourdeaut F, Cabaret O, Caron O, Duval A, Entz-Werle N, Goldberg Y, Ilencikova D, Kratz CP, Lavoine N, Loeffen J, Menko FH, Muleris M, Sebille G, Colas C, Burkhardt B, Brugieres L, Wimmer K (2014) Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium “Care for CMMR-D” (C4CMMR-D). J Med Genet 51(5):283–293. doi:10.​1136/​jmedgenet-2013-102238 CrossRefPubMed
13.
go back to reference Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L (2014) Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium ‘care for CMMRD’ (C4CMMRD). J Med Genet 51(6):355–365. doi:10.1136/jmedgenet-2014-102284 CrossRefPubMed Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L (2014) Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium ‘care for CMMRD’ (C4CMMRD). J Med Genet 51(6):355–365. doi:10.​1136/​jmedgenet-2014-102284 CrossRefPubMed
Metadata
Title
A new hereditary colorectal cancer network in the Middle East and eastern mediterranean countries to improve care for high-risk families
Authors
Zeinab Ghorbanoghli
Carol Jabari
Walid Sweidan
Wail Hammoudeh
George Cortas
Ala I. Sharara
Amal Abedrabbo
Ijad Hourani
Bahareh Mahjoubi
Keivan Majidzadeh
Nurdan Tözün
Hadia Ziada-Bouchaar
Waseem Hamoudi
Osama Diab
Hamid Reza Khorram Khorshid
Henry Lynch
Hans Vasen
Publication date
01-04-2018
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 2/2018
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-017-0018-6

Other articles of this Issue 2/2018

Familial Cancer 2/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine