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Familial Cancer
Published in: Familial Cancer 4/2010

01-12-2010

FAP, gastric cancer, and genetic counseling featuring children and young adults: a family study and review

Authors: Henry T. Lynch, Carrie Snyder, Janine M. Davies, Stephen Lanspa, Jane Lynch, Zoran Gatalica, Victoria Graeve, Jason Foster

Published in: Familial Cancer | Issue 4/2010

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Abstract

Familial adenomatous polyposis is a highly complex and multifaceted colorectal cancer prone disorder which is often significantly confounded by extracolonic cancers inclusive of gastric cancer, a significant problem in the Orient. Gastric cancer in familial adenomatous polyposis is heavily influenced by fundic gland polyps which are often so voluminous as to defy effective endoscopic surveillance. This study involves more than two decades of investigation of an attenuated familial adenomatous polyposis family where gastric cancer posed an early diagnostic problem because it was obscured by multiple fundic gland polyps. Fundic gland polyps are common in familial adenomatous polyposis and attenuated familial adenomatous polyposis and, if voluminous, may interfere with effective endoscopic gastric cancer surveillance. This family is believed to be the first of its type reported with focus upon education and genetic counseling in the setting of a family information service. Cancer control in familial adenomatous polyposis may be partially resolved through use of familial colorectal cancer registries, with greater attention to family history and its interpretation, genetic counseling, and clinical translation for diagnosis and management.
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Metadata
Title
FAP, gastric cancer, and genetic counseling featuring children and young adults: a family study and review
Authors
Henry T. Lynch
Carrie Snyder
Janine M. Davies
Stephen Lanspa
Jane Lynch
Zoran Gatalica
Victoria Graeve
Jason Foster
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 4/2010
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-010-9352-7

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