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01-07-2021 | Coronavirus | REVIEW

Prevalence of SARS-CoV-2 RNA on inanimate surfaces: a systematic review and meta-analysis

Authors: Simone Belluco, Marzia Mancin, Filippo Marzoli, Alessio Bortolami, Eva Mazzetto, Alessandra Pezzuto, Michela Favretti, Calogero Terregino, Francesco Bonfante, Roberto Piro

Published in: European Journal of Epidemiology | Issue 7/2021

Abstract

Coronavirus disease (COVID-19) is a respiratory disease affecting many people and able to be transmitted through direct and perhaps indirect contact. Direct contact transmission, mediated by aerosols or droplets, is widely demonstrated, whereas indirect transmission is only supported by collateral evidence such as virus persistence on inanimate surfaces and data from other similar viruses. The present systematic review aims to estimate SARS-CoV-2 prevalence on inanimate surfaces, identifying risk levels according to surface characteristics. Data were obtained from studies in published papers collected from two databases (PubMed and Embase) with the last search on 1 September 2020. Included studies had to be papers in English, had to deal with coronavirus and had to consider inanimate surfaces in real settings. Studies were coded according to our assessment of the risk that the investigated surfaces could be contaminated by SARS-CoV-2. A meta-analysis and a metaregression were carried out to quantify virus RNA prevalence and to identify important factors driving differences among studies. Thirty-nine out of forty retrieved paper reported studies carried out in healthcare settings on the prevalence of virus RNA, five studies carry out also analyses through cell culture and six tested the viability of isolated viruses. Overall prevalences of SARS-CoV-2 RNA on high-, medium- and low-risk surfaces were 0.22 (CI₉₅ [0.152–0.296]), 0.04 (CI₉₅ [0.007–0.090]), and 0.00 (CI₉₅ [0.00–0.019]), respectively. The duration surfaces were exposed to virus sources (patients) was the main factor explaining differences in prevalence.

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Title: Prevalence of SARS-CoV-2 RNA on inanimate surfaces: a systematic review and meta-analysis
Authors: Simone Belluco
Marzia Mancin
Filippo Marzoli
Alessio Bortolami
Eva Mazzetto
Alessandra Pezzuto
Michela Favretti
Calogero Terregino
Francesco Bonfante
Roberto Piro
Publication date: 01-07-2021
Publisher: Springer Netherlands
Keywords: Coronavirus
SARS-CoV-2
COVID-19
Published in: European Journal of Epidemiology / Issue 7/2021
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-021-00784-y

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Prevalence of SARS-CoV-2 RNA on inanimate surfaces: a systematic review and meta-analysis

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