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Published in: European Journal of Epidemiology 12/2018

Open Access 01-12-2018 | CORRESPONDENCE

The Diesel Exhaust in Miners Study provides no evidence for an increase in risk for lung cancer in miners exposed to diesel engine emissions

Author: Matthias Möhner

Published in: European Journal of Epidemiology | Issue 12/2018

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Abstract

The Diesel Exhaust in Miners Study is unquestionably the most suitable data material to date to examine a possible link between diesel engine emissions and lung cancer risk. But the results do not appear to be consistent in themselves. The crucial methodological problem in this study, however, has yet to be discovered, to which the lack of any description of age related information (year of birth, year of hire, year of first exposure, year of death) for the cohort as well as for the cases might have contributed. This information is important to understand the flaws in the analysis. It turns out that the year of birth is associated with the exposure, i.e. with the chance to be exposed over a certain period of time as well as with the chance to be an ever-smoker. A further important issue for the interpretation of the results is the validity of the data on smoking, which are mainly obtained from next of kin for decedents up to 50 years after death. Taking all these aspects into account, it can be concluded that only the SMR-analysis can be considered from all published results.
Literature
3.
go back to reference IARC. Diesel and gasoline engine exhausts and some nitroarenes. In: IARC, editor.: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 105; 2014. IARC. Diesel and gasoline engine exhausts and some nitroarenes. In: IARC, editor.: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 105; 2014.
4.
go back to reference HEI. Diesel emissions and lung cancer: an evaluation of recent epidemiological evidence for quantitative risk assessment. Boston: Health Effects Institute; 2015. HEI. Diesel emissions and lung cancer: an evaluation of recent epidemiological evidence for quantitative risk assessment. Boston: Health Effects Institute; 2015.
6.
go back to reference Chang ET, Lau EC, Van Landingham C, Crump KS, McClellan RO, Moolgavkar SH. Reanalysis of diesel engine exhaust and lung cancer mortality in the Diesel Exhaust in Miners Study (DEMS) cohort using alternative exposure estimates and radon adjustment. Am J Epidemiol. 2018. https://doi.org/10.1093/aje/kwy038. Chang ET, Lau EC, Van Landingham C, Crump KS, McClellan RO, Moolgavkar SH. Reanalysis of diesel engine exhaust and lung cancer mortality in the Diesel Exhaust in Miners Study (DEMS) cohort using alternative exposure estimates and radon adjustment. Am J Epidemiol. 2018. https://​doi.​org/​10.​1093/​aje/​kwy038.
20.
go back to reference Steenland K, Schnorr T. Availability and accuracy of cancer and smoking data obtained from next of kin for decedents in a retrospective cohort study. J Occup Med. 1988;30(4):348–53.PubMed Steenland K, Schnorr T. Availability and accuracy of cancer and smoking data obtained from next of kin for decedents in a retrospective cohort study. J Occup Med. 1988;30(4):348–53.PubMed
21.
go back to reference Brüske-Hohlfeld I, Möhner M, Pohlabeln H, Ahrens W, Bolm-Audorff U, Kreienbrock L, et al. Occupational lung cancer risk for men in Germany: results from a pooled case-control study. Am J Epidemiol. 2000;151(4):384–95.CrossRefPubMed Brüske-Hohlfeld I, Möhner M, Pohlabeln H, Ahrens W, Bolm-Audorff U, Kreienbrock L, et al. Occupational lung cancer risk for men in Germany: results from a pooled case-control study. Am J Epidemiol. 2000;151(4):384–95.CrossRefPubMed
Metadata
Title
The Diesel Exhaust in Miners Study provides no evidence for an increase in risk for lung cancer in miners exposed to diesel engine emissions
Author
Matthias Möhner
Publication date
01-12-2018
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 12/2018
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-018-0455-z

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