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Open Access 01-04-2018 | CARDIOVASCULAR DISEASE

Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

Authors: Ryan J. Billar, Maarten J. G. Leening, Daphne Merkus, Guy G. O. Brusselle, Albert Hofman, Bruno H. Ch. Stricker, H. Ardeschir Ghofrani, Oscar H. Franco, Henning Gall, Janine F. Felix

Published in: European Journal of Epidemiology | Issue 4/2018

Abstract

Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available. We studied the cross-sectional associations of left heart structure and systolic and diastolic function with echocardiographically measured pulmonary artery systolic pressure. Mean pulmonary artery systolic pressure was 25.4 mmHg. After multivariable-adjustment measures of both structure and function were independently associated with pulmonary artery systolic pressure: E/A ratio [0.63 mmHg (95% CI 0.35–0.91) per 1-SD increase], left atrial diameter [0.79 mmHg (0.50–1.09) per 1-SD increase], E/E′ ratio [1.27 mmHg (0.92–1.61) per 1-SD increase], left ventricular volume [0.62 mmHg (0.25–0.98) per 1-SD increase], fractional shortening [0.45 mmHg (0.17–0.74) per 1-SD increase], aortic root diameter [− 0.43 mmHg (− 0.72 to − 0.14) per 1-SD increase], mitral valve deceleration time [− 0.31 mmHg (− 0.57 to − 0.05) per 1-SD increase], and E′ [1.04 mmHg (0.66–1.42) per 1-SD increase]. Results did not materially differ when restricting the analyses to participants free of symptoms of shortness of breath. Structural and functional echocardiographic parameters of subclinical cardiac dysfunction and increased filling pressures are associated with pulmonary arterial pressures in the unselected general ageing population.

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Title: Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study
Authors: Ryan J. Billar
Maarten J. G. Leening
Daphne Merkus
Guy G. O. Brusselle
Albert Hofman
Bruno H. Ch. Stricker
H. Ardeschir Ghofrani
Oscar H. Franco
Henning Gall
Janine F. Felix
Publication date: 01-04-2018
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 4/2018
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-017-0341-0

At a glance: The ONWARDS insulin icodec trials

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Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

Abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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