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01-09-2016 | CANCER

Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States

Authors: Melina Arnold, Heinz Freisling, Rachael Stolzenberg-Solomon, Frank Kee, Mark George O’Doherty, José Manuel Ordóñez-Mena, Tom Wilsgaard, Anne Maria May, Hendrik Bas Bueno-de-Mesquita, Anne Tjønneland, Philippos Orfanos, Antonia Trichopoulou, Paolo Boffetta, Freddie Bray, Mazda Jenab, Isabelle Soerjomataram, on behalf of the CHANCES consortium

Published in: European Journal of Epidemiology | Issue 9/2016

Abstract

Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI ≥ 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer [overall hazard ratio (HR) per 10-year increment: 1.36; 95 % CI 1.12–1.60], but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4 % of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies.

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Title: Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States
Authors: Melina Arnold
Heinz Freisling
Rachael Stolzenberg-Solomon
Frank Kee
Mark George O’Doherty
José Manuel Ordóñez-Mena
Tom Wilsgaard
Anne Maria May
Hendrik Bas Bueno-de-Mesquita
Anne Tjønneland
Philippos Orfanos
Antonia Trichopoulou
Paolo Boffetta
Freddie Bray
Mazda Jenab
Isabelle Soerjomataram
on behalf of the CHANCES consortium
Publication date: 01-09-2016
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 9/2016
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-016-0169-z

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Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States

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