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Open Access 01-04-2015 | GENETIC EPIDEMIOLOGY

Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study

Authors: Carolina Medina-Gomez, Janine Frédérique Felix, Karol Estrada, Marjoline Josephine Peters, Lizbeth Herrera, Claudia Jeanette Kruithof, Liesbeth Duijts, Albert Hofman, Cornelia Marja van Duijn, Andreas Gerardus Uitterlinden, Vincent Wilfred Vishal Jaddoe, Fernando Rivadeneira

Published in: European Journal of Epidemiology | Issue 4/2015

Abstract

Genome-wide association studies (GWAS) have been successful in identifying loci associated with a wide range of complex human traits and diseases. Up to now, the majority of GWAS have focused on European populations. However, the inclusion of other ethnic groups as well as admixed populations in GWAS studies is rapidly rising following the pressing need to extrapolate findings to non-European populations and to increase statistical power. In this paper, we describe the methodological steps surrounding genetic data generation, quality control, study design and analytical procedures needed to run GWAS in the multiethnic and highly admixed Generation R Study, a large prospective birth cohort in Rotterdam, the Netherlands. Furthermore, we highlight a number of practical considerations and alternatives pertinent to the quality control and analysis of admixed GWAS data.

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Title: Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
Authors: Carolina Medina-Gomez
Janine Frédérique Felix
Karol Estrada
Marjoline Josephine Peters
Lizbeth Herrera
Claudia Jeanette Kruithof
Liesbeth Duijts
Albert Hofman
Cornelia Marja van Duijn
Andreas Gerardus Uitterlinden
Vincent Wilfred Vishal Jaddoe
Fernando Rivadeneira
Publication date: 01-04-2015
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 4/2015
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-015-9998-4

At a glance: The STEP trials

Springer Medicine

Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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