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European Journal of Epidemiology
Published in: European Journal of Epidemiology 2/2016

01-02-2016 | REVIEW

What is the role of modifiable environmental and lifestyle risk factors in young onset dementia?

Authors: Monica Cations, Adrienne Withall, Lee-Fay Low, Brian Draper

Published in: European Journal of Epidemiology | Issue 2/2016

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Abstract

Young onset dementia (YOD) is associated with significant costs and burden, but its cause is poorly understood. The aim of this review was to determine whether environmental and lifestyle factors are associated with risk for non-autosomal dominant degenerative and vascular YOD. Academic databases were searched to March 2015 for studies assessing the impact of modifiable factors (e.g. education, cardiovascular illness, psychiatric illness, alcohol use) in participants under 65 years at symptom onset. Cardiovascular illness, traumatic brain injury, psychiatric illness, heavy alcohol use and estrogen-related factors were identified as potential risk factors for YOD. Evidence for education, childhood development, smoking and heavy metal exposure was inconsistent or of poor quality. A dose–response relationship was found between cumulative and/or increasing severity of exposure and risk for YOD. Environmental and lifestyle risk factors may be relevant to YOD, particularly with severe or cumulative exposure. More high quality research is required to confirm which factors confer risk and when.
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Metadata
Title
What is the role of modifiable environmental and lifestyle risk factors in young onset dementia?
Authors
Monica Cations
Adrienne Withall
Lee-Fay Low
Brian Draper
Publication date
01-02-2016
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 2/2016
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-015-0103-9

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