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Open Access 01-05-2011 | PERINATAL EPIDEMIOLOGY

Chlamydia trachomatis and placental inflammation in early preterm delivery

Authors: G. Ingrid J. G. Rours, Ronald R. de Krijger, Alewijn Ott, Hendrina F. M. Willemse, Ronald de Groot, Luc J. I. Zimmermann, Renee F. Kornelisse, Henri A. Verbrugh, Roel P. Verkooijen

Published in: European Journal of Epidemiology | Issue 5/2011

Abstract

Chlamydia trachomatis may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of Chlamydia trachomatis and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. C. trachomatis testing of placentas was done retrospectively using PCR. C. trachomatis was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with C. trachomatis versus 82/228 (36%) placentas without C. trachomatis infection (OR 2.1, 95% CI 1.2–3.5). C. trachomatis infection correlated with the progression (P = 0.009) and intensity (P = 0.007) of materno-fetal placental inflammation. C. trachomatis DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.

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Title: Chlamydia trachomatis and placental inflammation in early preterm delivery
Authors: G. Ingrid J. G. Rours
Ronald R. de Krijger
Alewijn Ott
Hendrina F. M. Willemse
Ronald de Groot
Luc J. I. Zimmermann
Renee F. Kornelisse
Henri A. Verbrugh
Roel P. Verkooijen
Publication date: 01-05-2011
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 5/2011
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-011-9569-2

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Chlamydia trachomatis and placental inflammation in early preterm delivery

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