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Investigational New Drugs
Published in: Investigational New Drugs 3/2018

01-06-2018 | PRECLINICAL STUDIES

Cyclodextrin polymers as nanocarriers for sorafenib

Authors: Valentina Giglio, Maurizio Viale, Vittorio Bertone, Irena Maric, Rita Vaccarone, Graziella Vecchio

Published in: Investigational New Drugs | Issue 3/2018

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Summary

Polymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we investigated cyclodextrin cross-linked polymers with different lengths as carriers for the poorly water-soluble drug sorafenib. Both polymers significantly enhanced sorafenib solubility, with shorter polymers showing the most effective solubilizing effect. Inclusion complexes between sorafenib and the investigated polymers exhibited an antiproliferative effect in tumor cells similar to that of free sorafenib. Polymer/Sorafenib complexes also showed lower in vivo tissue toxicity than with free sorafenib in all organs. Our results suggest that the inclusion of sorafenib in polymers represents a successful strategy for a new formulation of this drug.
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Metadata
Title
Cyclodextrin polymers as nanocarriers for sorafenib
Authors
Valentina Giglio
Maurizio Viale
Vittorio Bertone
Irena Maric
Rita Vaccarone
Graziella Vecchio
Publication date
01-06-2018
Publisher
Springer US
Published in
Investigational New Drugs / Issue 3/2018
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI
https://doi.org/10.1007/s10637-017-0538-9

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