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Investigational New Drugs
Published in: Investigational New Drugs 6/2017

Open Access 01-12-2017 | REVIEW

Mechanisms of cancer cell killing by sea cucumber-derived compounds

Authors: Teresa Liliana Wargasetia, Widodo

Published in: Investigational New Drugs | Issue 6/2017

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Summary

The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.
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Metadata
Title
Mechanisms of cancer cell killing by sea cucumber-derived compounds
Authors
Teresa Liliana Wargasetia
Widodo
Publication date
01-12-2017
Publisher
Springer US
Published in
Investigational New Drugs / Issue 6/2017
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI
https://doi.org/10.1007/s10637-017-0505-5

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