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01-12-2007 | PHASE II STUDIES

Phase II trial of alternating intravenous and oral vinorelbine in combination with cisplatin in advanced non-small cell lung cancer

Authors: Elisabetta Campagnoli, Isabella Garassino, Armando Santoro, Fabio De Vincenzo, Paolo Andrea Zucali, Giovanni Luca Ceresoli, Fabio Romano Lutman, Marco Alloisio, Hector Josè Soto Parra, Raffaele Cavina

Published in: Investigational New Drugs | Issue 6/2007

Summary

Cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). Several platinum-based doublets have been tested in phase II/III trials with equivalent results in terms of tumour response and survival. Our study was designed to evaluate activity, tolerability and convenience of alternating intravenous (i.v.) and oral vinorelbine in combination with cisplatin in advanced NSCLC. Forty chemo-naive patients with stage IV or relapsed unresectable disease and good performance status were enrolled to receive i.v. cisplatin 40 mg/m² on days 1 and 2 plus i.v. vinorelbine 25 mg/m² on day 1, every 3 weeks. Oral vinorelbine 60 mg/m² was given at home on day 5, without checking of blood cell count. A total of 175 treatment cycles were delivered. The overall response rate was 30% (one complete, 11 partial responses). Median time to progression and overall survival were 5 and 10 months, respectively. The main toxicity was haematological, with grade 3–4 neutropenia observed in 75% of patients, without febrile neutropenia. Non-haematological toxicity was mild. This schedule of cisplatin and vinorelbine treatment showed a good toxicity profile and an efficacy similar to other standard regimens. Oral vinorelbine could be administered safely at home on day 5.

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Title: Phase II trial of alternating intravenous and oral vinorelbine in combination with cisplatin in advanced non-small cell lung cancer
Authors: Elisabetta Campagnoli
Isabella Garassino
Armando Santoro
Fabio De Vincenzo
Paolo Andrea Zucali
Giovanni Luca Ceresoli
Fabio Romano Lutman
Marco Alloisio
Hector Josè Soto Parra
Raffaele Cavina
Publication date: 01-12-2007
Publisher: Springer US
Published in: Investigational New Drugs / Issue 6/2007
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-007-9067-2

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