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Documenta Ophthalmologica

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01-02-2015 | Clinical Case Report

Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs

Authors: Shinji Ueno, Ayami Nakanishi, Kayo Nishi, Shiro Suzuki, Hiroko Terasaki

Published in: Documenta Ophthalmologica | Issue 1/2015

Abstract

Purpose

To report a patient with cancer-associated retinopathy and retinal ON-bipolar cell dysfunction who had a resolution of the electroretinograms (ERGs) after a resection of an ovarian cancer and chemotherapy.

Case report

A 71-year-old Japanese female patient visited us complaining of night blindness and photopsia in both eyes for 6 months. Her visual acuity was 20/20 in both eyes, and fundus examination, fluorescence angiography, and optical coherence tomography showed no abnormalities in both eyes. The rod responses of the ERGs were absent and bright-flash ERGs were electronegative. The ON responses of the focal macular ERGs and full-field long-flash ERGs were absent. These ERG findings indicate an ON-bipolar cell dysfunction. A general physical examination revealed the presence of ovarian cancer. After resection of the ovarian cancer and adjuvant chemotherapy, the ERGs of the left eye completely recovered within 2 years and those of right eye recovered subsequently. The autoantibody against transient receptor potential melastatin 1 (TRPM1) was not detected in the serum.

Conclusion

Our case demonstrates that retinal ON-bipolar dysfunction can be caused by ovarian cancer. Our case indicates that some autoantibodies against other than TRPM1 might cause transient dysfunction of retinal ON-bipolar cells.

Berson EL, Lessell S (1988) Para-neoplastic night blindness with malignant-melanoma. Am J Ophthalmol 106:307–311. doi:10.1016/0002-9394(88)90366-2 PubMedCrossRef

Keltner JL, Thirkill CE, Yip PT (2001) Clinical and immunologic characteristics of melanoma-associated retinopathy syndrome: eleven new cases and a review of 51 previously published cases. J Neuro Ophthalmol 21:173–187. doi:10.1097/00041327-200109000-00004 CrossRef

Milam AH, Saari JC, Jacobson SG, Lubinski WP, Feun LG, Alexander KR (1993) Autoantibodies against retinal bipolar cells in cutaneous melanoma-associated retinopathy. Invest Ophthalmol Vis Sci 34:91–100PubMed

Alexander KR, Barnes CS, Fishman GA, Milam AH (2002) Nature of the cone ON-pathway dysfunction in melanoma-associated retinopathy. Invest Ophthalmol Vis Sci 43:1189–1197PubMed

Alexander KR, Fishman GA, Peachey NS, Marchese AL, Tso MOM (1992) ON response defect in paraneoplastic night blindness with cutaneous malignant-melanoma. Invest Ophthalmol Vis Sci 33:477–483PubMed

Anastasakis A, Dick AD, Damato EM, Spry PG, Majid MA (2011) Cancer-associated retinopathy presenting as retinal vasculitis with a negative ERG suggestive of on-bipolar cell pathway dysfunction. Doc Ophthalmol 123:59–63. doi:10.1007/s10633-011-9277-y PubMedCrossRef

Kim LS, Alexander KR, Fishman GA (2008) Spontaneous improvement of rod system function in a patient with melanoma-associated retinopathy. Retin Cases Brief Rep 2:166–171PubMedCentralPubMedCrossRef

Stead RE, Fox MA, Staples E, Lim CS (2013) Delayed presentation of melanoma-associated retinopathy and subsequent resolution with cytoreduction surgery. Doc Ophthalmol 127:165–171. doi:10.1007/s10633-013-9398-6 PubMedCrossRef

Yamamoto S, Hanaya J, Mera K, Miyata K (2013) Recovery of visual function in patient with melanoma-associated retinopathy treated with surgical resection and interferon-beta (vol 124, pg 143, 2012). Doc Ophthalmol 126:259. doi:10.1007/s10633-013-9376-z CrossRef

10.

Goetgebuer G, Kestelyn-Stevens A-M, De Laey J-J, Kestelyn P, Leroy BP (2008) Cancer-associated retinopathy (CAR) with electronegative ERG: a case report. Doc Ophthalmol 116:49–55. doi:10.1007/s10633-007-9074-9 PubMedCrossRef

11.

Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T (2011) Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS one 6:e19911. doi:10.1371/journal.pone.0019911 PubMedCentralPubMedCrossRef

12.

Miyake Y, Shiroyama N, Horiguchi M, Ota I (1989) Asymmetry of focal ERG in human macular region. Invest Ophthalmol Vis Sci 30:1743–1749PubMed

13.

Ueno S, Koyasu T, Kominami T, Sakai T, Kondo M, Yasuda S, Terasaki H (2013) Focal cone ERGs of rhodopsin Pro347Leu transgenic rabbits. Vision Res 91:118–123PubMedCrossRef

14.

Hibi N, Ueno S, Ito Y, Piao C-H, Kondo M, Terasaki H (2013) Relationship between retinal layer thickness and focal macular electroretinogram components after epiretinal membrane surgery. Invest Ophthalmol Vis Sci 54:7207–7214. doi:10.1167/iovs.13-12884 PubMedCrossRef

15.

Miyake Y, Yagasaki K, Horiguchi M, Kawase Y, Kanda T (1986) Congenital stationary night blindness with negative electroretinogram: a new classification. Arch Ophthalmol 104:1013–1020PubMedCrossRef

16.

Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma TR, Yasuda S, Kuno N, Takahashi M, Terasaki H (2013) Degeneration of retinal ON bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy. PLoS one 8:e81507. doi:10.1371/journal.pone.0081507

17.

Dhingra A, Fina ME, Neinstein A, Ramsey DJ, Xu Y, Fishman GA, Alexander KR, Qian H, Peachey NS, Gregg RG, Vardi N (2011) Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci 31:3962–3967. doi:10.1523/JNEUROSCI.6007-10.2011

18.

Duncan LM, Deeds J, Cronin FE, Donovan M, Sober AJ, Kauffman M, McCarty JJ (2001) Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol 19:568–576PubMed

19.

Zimov S, Yazulla S (2004) Localization of vanilloid receptor 1 (TRPV1/VR1)-like immunoreactivity in goldfish and zebrafish retinas: restriction to photoreceptor synaptic ribbons. J Neurocytol 33:441–452. doi:10.1023/B:NEUR.0000046574.72380.e8 PubMedCrossRef

20.

Morgans CW, Zhang J, Jeffrey BG, Nelson SM, Burke NS, Duvoisin RM, Brown RL (2009) TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc Natl Acad Sci USA 106:19174–19178. doi:10.1073/pnas.0908711106 PubMedCentralPubMedCrossRef

21.

Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T (2010) TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci USA 107:332–337. doi:10.1073/pnas.0912730107 PubMedCentralPubMedCrossRef

22.

Xiong W-H, Duvoisin RM, Adamus G, Jeffrey BG, Gellman C, Morgans CW (2013) Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal ON-bipolar Cells and attenuate the electroretinogram in mice. PLoS one 8:e69506. doi:10.1371/journal.pone.0069506 PubMedCentralPubMedCrossRef

Title: Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs
Authors: Shinji Ueno
Ayami Nakanishi
Kayo Nishi
Shiro Suzuki
Hiroko Terasaki
Publication date: 01-02-2015
Publisher: Springer Berlin Heidelberg
Published in: Documenta Ophthalmologica / Issue 1/2015
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-014-9470-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs

Abstract

Purpose

Case report

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Case report

Conclusion

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