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Documenta Ophthalmologica
Published in: Documenta Ophthalmologica 2/2014

01-04-2014 | Review Article

Mouse b-wave mutants

Authors: Machelle T. Pardue, Neal S. Peachey

Published in: Documenta Ophthalmologica | Issue 2/2014

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Abstract

The b-wave is a major component of the electroretinogram that reflects the activity of depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with defects in DBC signaling or in transmission from photoreceptors to DBCs. In mouse models, an abnormal b-wave has been used to demonstrate a critical role of a particular protein in the release of glutamate from photoreceptor terminals, in establishing the structure of the photoreceptor-to-DBC synapse, in DBC signal transduction, and also in DBC development, survival, or metabolic support. The purpose of this review is to summarize these models and how they have advanced our understanding of outer retinal function.
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Metadata
Title
Mouse b-wave mutants
Authors
Machelle T. Pardue
Neal S. Peachey
Publication date
01-04-2014
Publisher
Springer Berlin Heidelberg
Published in
Documenta Ophthalmologica / Issue 2/2014
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-013-9424-8

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