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Published in: Documenta Ophthalmologica 2/2012

01-10-2012 | Original Research Article

Global flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes

Authors: J. C. Y. Lung, P. G. Swann, D. S. H. Wong, H. H. L. Chan

Published in: Documenta Ophthalmologica | Issue 2/2012

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Abstract

Purpose To investigate the correlations of the global flash multifocal electroretinogram (MOFO mfERG) with common clinical visual assessments—Humphrey perimetry and Stratus circumpapillary retinal nerve fiber layer (RNFL) thickness measurement in type II diabetic patients. Methods Forty-two diabetic patients participated in the study: Ten were free from diabetic retinopathy (DR), while the remainder suffered from mild to moderate nonproliferative diabetic retinopathy. Fourteen age-matched controls were recruited for comparison. MOFO mfERG measurements were made under high- and low-contrast conditions. Humphrey central 30-2 perimetry and Stratus OCT circumpapillary RNFL thickness measurements were also performed. Correlations between local values of implicit time and amplitude of the mfERG components [direct component (DC) and induced component (IC)], and perimetric sensitivity and RNFL thickness were evaluated by mapping the localized responses for the three subject groups. Results MOFO mfERG was superior to perimetry and RNFL assessments in showing differences between the diabetic groups (with and without DR) and the controls. All the MOFO mfERG amplitudes (except IC amplitude at high contrast) correlated better with perimetry findings (Pearson’s r ranged from 0.23 to 0.36, p < 0.01) than did the mfERG implicit time at both high and low contrasts across all subject groups. No consistent correlation was found between the mfERG and RNFL assessments for any group or contrast conditions. The responses of the local MOFO mfERG correlated with local perimetric sensitivity but not with RNFL thickness. Conclusion Early functional changes in the diabetic retina seem to occur before morphological changes in the RNFL.
Literature
1.
go back to reference Van Bijsterveld OP (2000) Diabetic retinopathy. Martin Dunitz Ltd., London, p 2 Van Bijsterveld OP (2000) Diabetic retinopathy. Martin Dunitz Ltd., London, p 2
2.
go back to reference Porta M, Bandello F (2002) Diabetic retinopathy—a clinical update. Diabetologia 45(12):1617–1634PubMedCrossRef Porta M, Bandello F (2002) Diabetic retinopathy—a clinical update. Diabetologia 45(12):1617–1634PubMedCrossRef
3.
go back to reference Barber AJ (2003) A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 27(2):283–290PubMedCrossRef Barber AJ (2003) A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 27(2):283–290PubMedCrossRef
4.
go back to reference Barber AJ, Gardner TW, Abcouwer SF (2011) The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci 52(2):1156–1163PubMedCrossRef Barber AJ, Gardner TW, Abcouwer SF (2011) The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci 52(2):1156–1163PubMedCrossRef
5.
go back to reference Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW (1998) Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 102(4):783–791PubMedCrossRef Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW (1998) Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 102(4):783–791PubMedCrossRef
6.
7.
go back to reference Lopes de Faria JM, Russ H, Costa VP (2002) Retinal nerve fibre layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol 86(7):725–728PubMedCrossRef Lopes de Faria JM, Russ H, Costa VP (2002) Retinal nerve fibre layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol 86(7):725–728PubMedCrossRef
8.
go back to reference Oshitari T, Hanawa K, Adachi-Usami E (2009) Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes. Eye (Lond) 23(4):884–889CrossRef Oshitari T, Hanawa K, Adachi-Usami E (2009) Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes. Eye (Lond) 23(4):884–889CrossRef
9.
go back to reference Ozdek S, Lonneville YH, Onol M, Yetkin I, Hasanreisoglu BB (2002) Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry. Eye (Lond) 16(6):761–765CrossRef Ozdek S, Lonneville YH, Onol M, Yetkin I, Hasanreisoglu BB (2002) Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry. Eye (Lond) 16(6):761–765CrossRef
10.
go back to reference Parravano M, Oddone F, Mineo D, Centofanti M, Borboni P, Lauro R, Tanga L, Manni G (2008) The role of Humphrey Matrix testing in the early diagnosis of retinopathy in type 1 diabetes. Br J Ophthalmol 92(12):1656–1660PubMedCrossRef Parravano M, Oddone F, Mineo D, Centofanti M, Borboni P, Lauro R, Tanga L, Manni G (2008) The role of Humphrey Matrix testing in the early diagnosis of retinopathy in type 1 diabetes. Br J Ophthalmol 92(12):1656–1660PubMedCrossRef
11.
go back to reference Takahashi H, Chihara E (2008) Impact of diabetic retinopathy on quantitative retinal nerve fiber layer measurement and glaucoma screening. Invest Ophthalmol Vis Sci 49(2):687–692PubMedCrossRef Takahashi H, Chihara E (2008) Impact of diabetic retinopathy on quantitative retinal nerve fiber layer measurement and glaucoma screening. Invest Ophthalmol Vis Sci 49(2):687–692PubMedCrossRef
12.
go back to reference Bengtsson B, Heijl A, Agardh E (2005) Visual fields correlate better than visual acuity to severity of diabetic retinopathy. Diabetologia 48(12):2494–2500PubMedCrossRef Bengtsson B, Heijl A, Agardh E (2005) Visual fields correlate better than visual acuity to severity of diabetic retinopathy. Diabetologia 48(12):2494–2500PubMedCrossRef
13.
go back to reference Bresnick GH, Condit RS, Palta M, Korth K, Groo A, Syrjala S (1985) Association of hue discrimination loss and diabetic retinopathy. Arch Ophthalmol 103(9):1317–1324PubMedCrossRef Bresnick GH, Condit RS, Palta M, Korth K, Groo A, Syrjala S (1985) Association of hue discrimination loss and diabetic retinopathy. Arch Ophthalmol 103(9):1317–1324PubMedCrossRef
14.
go back to reference Ismail GM, Whitaker D (1998) Early detection of changes in visual function in diabetes mellitus. Ophthalmic Physiol Opt 18(1):3–12PubMedCrossRef Ismail GM, Whitaker D (1998) Early detection of changes in visual function in diabetes mellitus. Ophthalmic Physiol Opt 18(1):3–12PubMedCrossRef
15.
go back to reference Kurtenbach A, Flogel W, Erb C (2002) Anomaloscope matches in patients with diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 240(2):79–84PubMedCrossRef Kurtenbach A, Flogel W, Erb C (2002) Anomaloscope matches in patients with diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 240(2):79–84PubMedCrossRef
16.
go back to reference Bengtsson B, Hellgren KJ, Agardh E (2008) Test-retest variability for standard automated perimetry and short-wavelength automated perimetry in diabetic patients. Acta Ophthalmol 86(2):170–176PubMedCrossRef Bengtsson B, Hellgren KJ, Agardh E (2008) Test-retest variability for standard automated perimetry and short-wavelength automated perimetry in diabetic patients. Acta Ophthalmol 86(2):170–176PubMedCrossRef
17.
go back to reference Sutter EE, Tran D (1992) The field topography of ERG components in man—I. The photopic luminance response. Vis Res 32(3):433–446PubMedCrossRef Sutter EE, Tran D (1992) The field topography of ERG components in man—I. The photopic luminance response. Vis Res 32(3):433–446PubMedCrossRef
18.
go back to reference Bearse MA Jr, Han Y, Schneck ME, Barez S, Jacobsen C, Adams AJ (2004) Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthalmol Vis Sci 45(9):3259–3265PubMedCrossRef Bearse MA Jr, Han Y, Schneck ME, Barez S, Jacobsen C, Adams AJ (2004) Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthalmol Vis Sci 45(9):3259–3265PubMedCrossRef
19.
go back to reference Bronson-Castain KW, Bearse MA Jr, Neuville J, Jonasdottir S, King-Hooper B, Barez S, Schneck ME, Adams AJ (2009) Adolescents with type 2 diabetes early indications of focal retinal neuropathy, retinal thinning, and venular dilation. Retina 29(5):618–626PubMedCrossRef Bronson-Castain KW, Bearse MA Jr, Neuville J, Jonasdottir S, King-Hooper B, Barez S, Schneck ME, Adams AJ (2009) Adolescents with type 2 diabetes early indications of focal retinal neuropathy, retinal thinning, and venular dilation. Retina 29(5):618–626PubMedCrossRef
20.
go back to reference Fortune B, Schneck ME, Adams AJ (1999) Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest Ophthalmol Vis Sci 40(11):2638–2651PubMed Fortune B, Schneck ME, Adams AJ (1999) Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest Ophthalmol Vis Sci 40(11):2638–2651PubMed
21.
go back to reference Holopigian K, Greenstein VC, Seiple W, Hood DC, Carr RE (1997) Evidence for photoreceptor changes in patients with diabetic retinopathy. Invest Ophthalmol Vis Sci 38(11):2355–2365PubMed Holopigian K, Greenstein VC, Seiple W, Hood DC, Carr RE (1997) Evidence for photoreceptor changes in patients with diabetic retinopathy. Invest Ophthalmol Vis Sci 38(11):2355–2365PubMed
22.
go back to reference Kizawa J, Machida S, Kobayashi T, Gotoh Y, Kurosaka D (2006) Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy. Jpn J Ophthalmol 50(4):367–373PubMedCrossRef Kizawa J, Machida S, Kobayashi T, Gotoh Y, Kurosaka D (2006) Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy. Jpn J Ophthalmol 50(4):367–373PubMedCrossRef
23.
go back to reference Luu CD, Szental JA, Lee SY, Lavanya R, Wong TY (2010) Correlation between retinal oscillatory potentials and retinal vascular caliber in type 2 diabetes. Invest Ophthalmol Vis Sci 51(1):482–486PubMedCrossRef Luu CD, Szental JA, Lee SY, Lavanya R, Wong TY (2010) Correlation between retinal oscillatory potentials and retinal vascular caliber in type 2 diabetes. Invest Ophthalmol Vis Sci 51(1):482–486PubMedCrossRef
24.
go back to reference Palmowski AM, Sutter EE, Bearse MA Jr, Fung W (1997) Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram. Invest Ophthalmol Vis Sci 38(12):2586–2596PubMed Palmowski AM, Sutter EE, Bearse MA Jr, Fung W (1997) Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram. Invest Ophthalmol Vis Sci 38(12):2586–2596PubMed
25.
go back to reference Shimada Y, Li Y, Bearse MA Jr, Sutter EE, Fung W (2001) Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 85(4):414–419PubMedCrossRef Shimada Y, Li Y, Bearse MA Jr, Sutter EE, Fung W (2001) Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 85(4):414–419PubMedCrossRef
26.
go back to reference Yamamoto S, Kamiyama M, Nitta K, Yamada T, Hayasaka S (1996) Selective reduction of the S cone electroretinogram in diabetes. Br J Ophthalmol 80(11):973–975PubMedCrossRef Yamamoto S, Kamiyama M, Nitta K, Yamada T, Hayasaka S (1996) Selective reduction of the S cone electroretinogram in diabetes. Br J Ophthalmol 80(11):973–975PubMedCrossRef
27.
go back to reference Chen H, Zhang M, Huang S, Wu D (2008) The photopic negative response of flash ERG in nonproliferative diabetic retinopathy. Doc Ophthalmol 117(2):129–135PubMedCrossRef Chen H, Zhang M, Huang S, Wu D (2008) The photopic negative response of flash ERG in nonproliferative diabetic retinopathy. Doc Ophthalmol 117(2):129–135PubMedCrossRef
28.
go back to reference Schneck ME, Bearse MA Jr, Han Y, Barez S, Jacobsen C, Adams AJ (2004) Comparison of mfERG waveform components and implicit time measurement techniques for detecting functional change in early diabetic eye disease. Doc Ophthalmol 108(3):223–230PubMedCrossRef Schneck ME, Bearse MA Jr, Han Y, Barez S, Jacobsen C, Adams AJ (2004) Comparison of mfERG waveform components and implicit time measurement techniques for detecting functional change in early diabetic eye disease. Doc Ophthalmol 108(3):223–230PubMedCrossRef
29.
go back to reference Tyrberg M, Ponjavic V, Lovestam-Adrian M (2005) Multifocal electroretinography (mfERG) in insulin dependent diabetics with and without clinically apparent retinopathy. Doc Ophthalmol 110(2–3):137–143PubMedCrossRef Tyrberg M, Ponjavic V, Lovestam-Adrian M (2005) Multifocal electroretinography (mfERG) in insulin dependent diabetics with and without clinically apparent retinopathy. Doc Ophthalmol 110(2–3):137–143PubMedCrossRef
30.
go back to reference Xu J, Hu G, Huang T, Huang H, Chen B (2006) Using multifocal ERG responses to discriminate diabetic retinopathy. Doc Ophthalmol 112(3):201–207PubMedCrossRef Xu J, Hu G, Huang T, Huang H, Chen B (2006) Using multifocal ERG responses to discriminate diabetic retinopathy. Doc Ophthalmol 112(3):201–207PubMedCrossRef
31.
go back to reference Yamamoto S, Takeuchi S, Kamiyama M (1997) The short wavelength-sensitive cone electroretinogram in diabetes: relationship to systemic factors. Doc Ophthalmol 94(3):193–200PubMedCrossRef Yamamoto S, Takeuchi S, Kamiyama M (1997) The short wavelength-sensitive cone electroretinogram in diabetes: relationship to systemic factors. Doc Ophthalmol 94(3):193–200PubMedCrossRef
32.
go back to reference Lung JCY, Tang GYB, Chu PHW, Ng YF, Chan HHL (2009) Abstracts of the XLVII international symposium of the ISCEV (International Society for Clinical Electrophysiology of Vision). Global flash mfERG in the early detection of the local functional changes of diabetic retinopathy lesions. Doc Ophthalmol 119(Suppl 1):17–92 Lung JCY, Tang GYB, Chu PHW, Ng YF, Chan HHL (2009) Abstracts of the XLVII international symposium of the ISCEV (International Society for Clinical Electrophysiology of Vision). Global flash mfERG in the early detection of the local functional changes of diabetic retinopathy lesions. Doc Ophthalmol 119(Suppl 1):17–92
33.
go back to reference Chu PH, Chan HH, Ng YF, Brown B, Siu AW, Beale BA, Gilger BC, Wong F (2008) Porcine global flash multifocal electroretinogram: possible mechanisms for the glaucomatous changes in contrast response function. Vision Res 48(16):1726–1734PubMedCrossRef Chu PH, Chan HH, Ng YF, Brown B, Siu AW, Beale BA, Gilger BC, Wong F (2008) Porcine global flash multifocal electroretinogram: possible mechanisms for the glaucomatous changes in contrast response function. Vision Res 48(16):1726–1734PubMedCrossRef
34.
go back to reference Lung JC, Chan HH (2010) Effects of luminance combinations on the characteristics of the global flash multifocal electroretinogram (mfERG). Graefes Arch Clin Exp Ophthalmol 248(8):1117–1125PubMedCrossRef Lung JC, Chan HH (2010) Effects of luminance combinations on the characteristics of the global flash multifocal electroretinogram (mfERG). Graefes Arch Clin Exp Ophthalmol 248(8):1117–1125PubMedCrossRef
35.
go back to reference Lung JC, Swann PG, Chan HH (2012) Early local functional changes in the human diabetic retina: a global flash multifocal electroretinogram study. Graefes Arch Clin Exp Ophthalmol. E-pub ahead. [PMID: 22527315] Lung JC, Swann PG, Chan HH (2012) Early local functional changes in the human diabetic retina: a global flash multifocal electroretinogram study. Graefes Arch Clin Exp Ophthalmol. E-pub ahead. [PMID: 22527315]
36.
go back to reference Chu PH, Chan HH, Brown B (2006) Glaucoma detection is facilitated by luminance modulation of the global flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 47(3):929–937PubMedCrossRef Chu PH, Chan HH, Brown B (2006) Glaucoma detection is facilitated by luminance modulation of the global flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 47(3):929–937PubMedCrossRef
37.
go back to reference Shimada Y, Bearse MA Jr, Sutter EE (2005) Multifocal electroretinograms combined with periodic flashes: direct responses and induced components. Graefes Arch Clin Exp Ophthalmol 243(2):132–141PubMedCrossRef Shimada Y, Bearse MA Jr, Sutter EE (2005) Multifocal electroretinograms combined with periodic flashes: direct responses and induced components. Graefes Arch Clin Exp Ophthalmol 243(2):132–141PubMedCrossRef
38.
go back to reference Han Y, Adams AJ, Bearse MA Jr, Schneck ME (2004) Multifocal electroretinogram and short-wavelength automated perimetry measures in diabetic eyes with little or no retinopathy. Arch Ophthalmol 122(12):1809–1815PubMedCrossRef Han Y, Adams AJ, Bearse MA Jr, Schneck ME (2004) Multifocal electroretinogram and short-wavelength automated perimetry measures in diabetic eyes with little or no retinopathy. Arch Ophthalmol 122(12):1809–1815PubMedCrossRef
39.
go back to reference Bearse MA Jr, Han Y, Schneck M, Adams A (2003) Enhancement and mapping of inner retinal contributions to the human multifocal electroretinogram (mfERG). Invest Ophthalmol Vis Sci 44. ARVO E-abstract 2696 Bearse MA Jr, Han Y, Schneck M, Adams A (2003) Enhancement and mapping of inner retinal contributions to the human multifocal electroretinogram (mfERG). Invest Ophthalmol Vis Sci 44. ARVO E-abstract 2696
40.
go back to reference Sutter EE, Bearse MA Jr (1999) The optic nerve head component of the human ERG. Vision Res 39(3):419–436PubMedCrossRef Sutter EE, Bearse MA Jr (1999) The optic nerve head component of the human ERG. Vision Res 39(3):419–436PubMedCrossRef
41.
go back to reference Wu S, Sutter EE (1995) A topographic study of oscillatory potentials in man. Vis Neurosci 12(6):1013–1025PubMedCrossRef Wu S, Sutter EE (1995) A topographic study of oscillatory potentials in man. Vis Neurosci 12(6):1013–1025PubMedCrossRef
42.
go back to reference Dersu I, Wiggins MN (2006) Understanding visual fields, Part II; Humphrey visual fields. J Ophthalmic Med Technol 2(3):1–7 Dersu I, Wiggins MN (2006) Understanding visual fields, Part II; Humphrey visual fields. J Ophthalmic Med Technol 2(3):1–7
43.
go back to reference Heijl A, Patella VM (2002) Essential perimetry: the field analyzer primer, 3rd edn. Carl Zeiss Meditec AG, Germany Heijl A, Patella VM (2002) Essential perimetry: the field analyzer primer, 3rd edn. Carl Zeiss Meditec AG, Germany
44.
go back to reference Garway-Heath DF, Holder GE, Fitzke FW, Hitchings RA (2002) Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma. Invest Ophthalmol Vis Sci 43(7):2213–2220PubMed Garway-Heath DF, Holder GE, Fitzke FW, Hitchings RA (2002) Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma. Invest Ophthalmol Vis Sci 43(7):2213–2220PubMed
45.
go back to reference Garway-Heath DF, Poinoosawmy D, Fitzke FW, Hitchings RA (2000) Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 107(10):1809–1815PubMedCrossRef Garway-Heath DF, Poinoosawmy D, Fitzke FW, Hitchings RA (2000) Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 107(10):1809–1815PubMedCrossRef
46.
go back to reference Nitta K, Saito Y, Kobayashi A, Sugiyama K (2006) Influence of clinical factors on blue-on-yellow perimetry for diabetic patients without retinopathy: comparison with white-on-white perimetry. Retina 26(7):797–802PubMedCrossRef Nitta K, Saito Y, Kobayashi A, Sugiyama K (2006) Influence of clinical factors on blue-on-yellow perimetry for diabetic patients without retinopathy: comparison with white-on-white perimetry. Retina 26(7):797–802PubMedCrossRef
47.
go back to reference Remky A, Weber A, Hendricks S, Lichtenberg K, Arend O (2003) Short-wavelength automated perimetry in patients with diabetes mellitus without macular edema. Graefes Arch Clin Exp Ophthalmol 241(6):468–471PubMedCrossRef Remky A, Weber A, Hendricks S, Lichtenberg K, Arend O (2003) Short-wavelength automated perimetry in patients with diabetes mellitus without macular edema. Graefes Arch Clin Exp Ophthalmol 241(6):468–471PubMedCrossRef
48.
go back to reference Bearse MA Jr, Sutter EE (1999) Contrast dependence of multifocal ERG components. Vis Sci Its Appl OSA Tech Dig Ser 1:24–27 Bearse MA Jr, Sutter EE (1999) Contrast dependence of multifocal ERG components. Vis Sci Its Appl OSA Tech Dig Ser 1:24–27
49.
go back to reference Hood DC, Greenstein V, Frishman L, Holopigian K, Viswanathan S, Seiple W, Ahmed J, Robson JG (1999) Identifying inner retinal contributions to the human multifocal ERG. Vision Res 39(13):2285–2291PubMedCrossRef Hood DC, Greenstein V, Frishman L, Holopigian K, Viswanathan S, Seiple W, Ahmed J, Robson JG (1999) Identifying inner retinal contributions to the human multifocal ERG. Vision Res 39(13):2285–2291PubMedCrossRef
50.
go back to reference Sutter EE, Shimada Y, Li Y, Bearse MA Jr (1999) Mapping inner retinal function through enhancement of adaptation components in the M-ERG. Vis Sci Its Appl OSA Tech Dig Ser 1:52–55 Sutter EE, Shimada Y, Li Y, Bearse MA Jr (1999) Mapping inner retinal function through enhancement of adaptation components in the M-ERG. Vis Sci Its Appl OSA Tech Dig Ser 1:52–55
51.
go back to reference Feigl B, Brown B, Lovie-Kitchin J, Swann P (2005) Adaptation responses in early age-related maculopathy. Invest Ophthalmol Vis Sci 46(12):4722–4727PubMedCrossRef Feigl B, Brown B, Lovie-Kitchin J, Swann P (2005) Adaptation responses in early age-related maculopathy. Invest Ophthalmol Vis Sci 46(12):4722–4727PubMedCrossRef
52.
go back to reference Luo X, Patel NB, Harwerth RS, Frishman LJ (2011) Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Invest Ophthalmol Vis Sci 52(6):3792–3804PubMedCrossRef Luo X, Patel NB, Harwerth RS, Frishman LJ (2011) Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Invest Ophthalmol Vis Sci 52(6):3792–3804PubMedCrossRef
53.
go back to reference Palmowski-Wolfe AM, Todorova MG, Orguel S, Flammer J, Brigell M (2007) The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma. Doc Ophthalmol 114(1):9–19PubMedCrossRef Palmowski-Wolfe AM, Todorova MG, Orguel S, Flammer J, Brigell M (2007) The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma. Doc Ophthalmol 114(1):9–19PubMedCrossRef
54.
go back to reference Bearse MA Jr, Adams AJ, Han Y, Schneck ME, Ng J, Bronson-Castain K, Barez S (2006) A multifocal electroretinogram model predicting the development of diabetic retinopathy. Prog Retin Eye Res 25(5):425–448PubMedCrossRef Bearse MA Jr, Adams AJ, Han Y, Schneck ME, Ng J, Bronson-Castain K, Barez S (2006) A multifocal electroretinogram model predicting the development of diabetic retinopathy. Prog Retin Eye Res 25(5):425–448PubMedCrossRef
55.
go back to reference Han Y, Bearse MA Jr, Schneck ME, Barez S, Jacobsen CH, Adams AJ (2004) Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci 45(3):948–954PubMedCrossRef Han Y, Bearse MA Jr, Schneck ME, Barez S, Jacobsen CH, Adams AJ (2004) Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci 45(3):948–954PubMedCrossRef
56.
go back to reference Harrison WW, Bearse MA Jr, Ng JS, Jewell NP, Barez S, Burger D, Schneck ME, Adams AJ (2011) Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci 52(2):772–777PubMedCrossRef Harrison WW, Bearse MA Jr, Ng JS, Jewell NP, Barez S, Burger D, Schneck ME, Adams AJ (2011) Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci 52(2):772–777PubMedCrossRef
57.
go back to reference Ng JS, Bearse MA Jr, Schneck ME, Barez S, Adams AJ (2008) Local diabetic retinopathy prediction by multifocal ERG delays over 3 years. Invest Ophthalmol Vis Sci 49(4):1622–1628PubMedCrossRef Ng JS, Bearse MA Jr, Schneck ME, Barez S, Adams AJ (2008) Local diabetic retinopathy prediction by multifocal ERG delays over 3 years. Invest Ophthalmol Vis Sci 49(4):1622–1628PubMedCrossRef
58.
go back to reference Sugimoto M, Sasoh M, Ido M, Wakitani Y, Takahashi C, Uji Y (2005) Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy. Ophthalmologica 219(6):379–385PubMedCrossRef Sugimoto M, Sasoh M, Ido M, Wakitani Y, Takahashi C, Uji Y (2005) Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy. Ophthalmologica 219(6):379–385PubMedCrossRef
59.
go back to reference Zhang L, Ino-ue M, Dong K, Yamamoto M (2000) Retrograde axonal transport impairment of large- and medium-sized retinal ganglion cells in diabetic rat. Curr Eye Res 20(2):131–136PubMedCrossRef Zhang L, Ino-ue M, Dong K, Yamamoto M (2000) Retrograde axonal transport impairment of large- and medium-sized retinal ganglion cells in diabetic rat. Curr Eye Res 20(2):131–136PubMedCrossRef
60.
go back to reference Greenstein VC, Hood DC, Ritch R, Steinberger D, Carr RE (1989) S (blue) cone pathway vulnerability in retinitis pigmentosa, diabetes and glaucoma. Invest Ophthalmol Vis Sci 30(8):1732–1737PubMed Greenstein VC, Hood DC, Ritch R, Steinberger D, Carr RE (1989) S (blue) cone pathway vulnerability in retinitis pigmentosa, diabetes and glaucoma. Invest Ophthalmol Vis Sci 30(8):1732–1737PubMed
61.
go back to reference Jeppesen P, Knudsen ST, Poulsen PL, Mogensen CE, Schmitz O, Bek T (2007) Response of retinal arteriole diameter to increased blood pressure during acute hyperglycaemia. Acta Ophthalmol Scand 85(3):280–286PubMedCrossRef Jeppesen P, Knudsen ST, Poulsen PL, Mogensen CE, Schmitz O, Bek T (2007) Response of retinal arteriole diameter to increased blood pressure during acute hyperglycaemia. Acta Ophthalmol Scand 85(3):280–286PubMedCrossRef
62.
go back to reference Klemp K, Larsen M, Sander B, Vaag A, Brockhoff PB, Lund-Andersen H (2004) Effect of short-term hyperglycemia on multifocal electroretinogram in diabetic patients without retinopathy. Invest Ophthalmol Vis Sci 45(10):3812–3819PubMedCrossRef Klemp K, Larsen M, Sander B, Vaag A, Brockhoff PB, Lund-Andersen H (2004) Effect of short-term hyperglycemia on multifocal electroretinogram in diabetic patients without retinopathy. Invest Ophthalmol Vis Sci 45(10):3812–3819PubMedCrossRef
Metadata
Title
Global flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes
Authors
J. C. Y. Lung
P. G. Swann
D. S. H. Wong
H. H. L. Chan
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
Documenta Ophthalmologica / Issue 2/2012
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-012-9343-0

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