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01-10-2011 | Original research article

Association of electroretinogram and morphological findings in branch retinal vein occlusion with macular edema

Authors: Hidetaka Noma, Hideharu Funatsu, Seiyo Harino, Takeshi Sugawara, Tatsuya Mimura, Katsunori Shimada

Published in: Documenta Ophthalmologica | Issue 2/2011

Abstract

The objective of this study is to evaluate the relations among electroretinogram parameters (cone a-wave, cone b-wave, and 30-Hz flicker), retinal thickness, and retinal volume in patients with branch retinal vein occlusion (BRVO) and macular edema. We prospectively examined 33 patients (33 eyes) with BRVO and macular edema. The amplitude and implicit time of the a-wave cone, b-wave cone, and 30-Hz flicker were calculated automatically from the ERG. Retinal thickness and volume were measured by optical coherence tomography (OCT) in nine macular subfields. Then, correlations between the ERG parameters and morphological parameters were analyzed. The 30-Hz flicker amplitude was significantly smaller in the eyes with BRVO and macular edema than in the unaffected contralateral eyes. Thirty-hertz flicker and cone b-wave implicit times were significantly longer in the eyes with macular edema than in the unaffected eyes. The implicit time of the cone b-wave was correlated with both retinal thickness and retinal volume in the temporal subfields. Thirty-hertz flicker amplitude was correlated with both retinal thickness and volume in the temporal and superior outer (site of occlusion) subfields, while 30-Hz flicker implicit time was correlated with retinal thickness and volume in the outer temporal subfield. Multiple regression analysis demonstrated that the retinal thickness and volume of the temporal subfields were significant “determinants” of the implicit time for the cone b-wave and 30-Hz flicker, as well as the 30-Hz flicker amplitude. These findings suggest that OCT parameters of the temporal region may reflect postreceptoral cone pathway function in BRVO patients with macular edema.

Michels RG, Gass JD (1974) The natural course of retinal branch vein obstruction. Trans Am Acad Ophthalmol Otolaryngol 78:166–177

Gutman FA, Zegarra H (1974) The natural course of temporal retinal branch vein occlusion. Trans Am Acad Ophthalmol Otolaryngol 78:178–192

Martinez-Jardon CS, Meza-de Regil A, Dalma-Weiszhausz J, Leizaola-Fernandez C, Morales-Canton V, Guerrero-Naranjo JL, Quiroz-Mercado H (2005) Radial optic neurotomy for ischaemic central vein occlusion. Br J Ophthalmol 89:558–561PubMedCrossRef

Kumagai K, Furukawa M, Ogino N, Uemura A, Larson E (2007) Long-term outcomes of vitrectomy with or without arteriovenous sheathotomy in branch retinal vein occlusion. Retina 27:49–54PubMedCrossRef

Hayreh SS, Klugman MR, Podhajsky P, Kolder HE (1989) Electroretinography in central retinal vein occlusion. Correlation of electroretinographic changes with pupillary abnormalities. Graefes Arch Clin Exp Ophthalmol 227:549–561PubMedCrossRef

Williamson TH, Keating D, Bradnam M (1997) Electroretinography of central retinal vein occlusion under scotopic and photopic conditions: what to measure? Acta Ophthalmol Scand 75:48–53PubMedCrossRef

Mustafi D, Engel AH, Palczewski K (2009) Structure of cone photoreceptors. Prog Retin Eye Res 28:289–302PubMedCrossRef

Zhang Y, Fortune B, Atchaneeyasakul LO, McFarland T, Mose K, Wallace P, Main J, Wilson D, Appukuttan B, Stout JT (2008) Natural history and histology in a rat model of laser-induced photothrombotic retinal vein occlusion. Curr Eye Res 33:365–376PubMedCrossRef

Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, Jian K, Sakamoto I, Nakano K, Yamashita H, Minamoto A, Mishima HK (2005) Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol 140:256–261PubMedCrossRef

10.

Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H, Mishima HK (2006) Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 244:309–315PubMedCrossRef

11.

Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, Hirayama T, Tamura H, Yamashita H, Minamoto A, Mishima HK (2008) Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion. Eye 22:42–48PubMedCrossRef

12.

Kirchhoff AC, Drum ML, Zhang JX, Schlichting J, Levie J, Harrison JF, Lippold SA, Schaefer CT, Chin MH (2008) Hypertension and hyperlipidemia management in patients treated at community health centers. J Clin Outcomes Manag 15:125–131PubMed

13.

Yamaike N, Kita M, Tsujikawa A, Miyamoto K, Yoshimura N (2007) Perimetric sensitivity with the micro perimeter 1 and retinal thickness in patients with branch retinal vein occlusion. Am J Ophthalmol 143:342–344PubMedCrossRef

14.

Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M, Bach M (2009) ISCEV Standard for full-field clinical electroretinography (2008 update). Doc Ophthalmol 118:69–77PubMedCrossRef

15.

Sieving PA (1993) Photopic ON- and OFF-pathway abnormalities in retinal dystrophies. Trans Am Ophthalmol Soc 91:701–773PubMed

16.

Sieving PA, Murayama K, Naarendorp F (1994) Push-pull model of the primate photopic electroretinogram: a role for hyperpolarizing neurons in shaping the b-wave. Vis Neurosci 11:519–532PubMedCrossRef

17.

Bush RA, Sieving PA (1996) Inner retinal contributions to the primate photopic fast flicker electroretinogram. J Opt Soc Am A Opt Image Sci Vis 13:557–565PubMedCrossRef

18.

Larsson J, Bauer B, Andreasson S (2000) The 30-Hz flicker cone ERG for monitoring the early course of central retinal vein occlusion. Acta Ophthalmol Scand 78:187–190PubMedCrossRef

19.

Larsson J, Andreasson S (2001) Photopic 30 Hz flicker ERG as a predictor for rubeosis in central retinal vein occlusion. Br J Ophthalmol 85:683–685PubMedCrossRef

20.

Chen H, Wu D, Huang S, Yan H (2006) The photopic negative response of the flash electroretinogram in retinal vein occlusion. Doc Ophthalmol 113:53–59PubMedCrossRef

21.

Vrabec F (1966) The temporal raphe of the human retina. Am J Ophthalmol 62:926–938PubMed

22.

Pai SA, Shetty R, Vijayan PB, Venkatasubramaniam G, Yadav NK, Shetty BK, Babu RB, Narayana KM (2007) Clinical, anatomic, and electrophysiologic evaluation following intravitreal bevacizumab for macular edema in retinal vein occlusion. Am J Ophthalmol 143:601–606PubMedCrossRef

23.

Silva MF, Mateus C, Reis A, Nunes S, Fonseca P, Castelo-Branco M (2010) Asymmetry of visual sensory mechanisms: electrophysiological, structural, and psychophysical evidences. J Vis 10:26PubMedCrossRef

Title: Association of electroretinogram and morphological findings in branch retinal vein occlusion with macular edema
Authors: Hidetaka Noma
Hideharu Funatsu
Seiyo Harino
Takeshi Sugawara
Tatsuya Mimura
Katsunori Shimada
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: Documenta Ophthalmologica / Issue 2/2011
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-011-9284-z

At a glance: The STEP trials

Springer Medicine

Association of electroretinogram and morphological findings in branch retinal vein occlusion with macular edema

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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