Skip to main content
Top
Published in: Clinical & Experimental Metastasis 5-6/2018

01-08-2018 | Review

Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves

Authors: Russell S. Witte, Chandra Karunakaran, Andres N. Zuniga, Hannah Schmitz, Hina Arif

Published in: Clinical & Experimental Metastasis | Issue 5-6/2018

Login to get access

Abstract

This review describes emerging techniques within the last 5 years that employ ultrasound for detecting and staging malignancy, tracking metastasis, and guiding treatment. Ultrasound elastography quantifies soft tissue elastic properties that change as a tumor grows and proliferates. Hybrid imaging modalities that combine ultrasound with light or microwave energy provide novel contrast for mapping blood oxygen saturation, transport of particles through lymphatic vessels and nodes, and real-time feedback for guiding needle biopsies. Combining these methods with smart nanoparticles and contrast agents further promotes new paradigms for cancer imaging and therapy.
Literature
1.
go back to reference Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C (2012) Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 31(2):281–287CrossRef Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C (2012) Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 31(2):281–287CrossRef
2.
go back to reference Sayed A, Layne G, Abraham J, Mukdadi OM (2014) 3-D visualization and non-linear tissue classification of breast tumors using ultrasound elastography in vivo. Ultrasound Med Biol 40(7):1490–1502CrossRef Sayed A, Layne G, Abraham J, Mukdadi OM (2014) 3-D visualization and non-linear tissue classification of breast tumors using ultrasound elastography in vivo. Ultrasound Med Biol 40(7):1490–1502CrossRef
3.
go back to reference Yang Y, Xu X, Guo L, He Y, Wang D, Liu B, Zhao C, Chen B, Xu H (2017) Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions. Sci Rep 7:40964CrossRef Yang Y, Xu X, Guo L, He Y, Wang D, Liu B, Zhao C, Chen B, Xu H (2017) Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions. Sci Rep 7:40964CrossRef
4.
go back to reference Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 71(2):452–456CrossRef Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 71(2):452–456CrossRef
5.
go back to reference Ho F, Tham IW, Earnest A, Lee KM, Lu JJ (2012) Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12:98CrossRef Ho F, Tham IW, Earnest A, Lee KM, Lu JJ (2012) Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12:98CrossRef
6.
go back to reference Azizi G, Keller JM, Mayo ML, Piper K, Puett D, Earp KM, Malchoff CD (2016) Shear wave elastography and cervical lymph nodes: predicting malignancy. Ultrasound Med Biol 42(6):1273–1281CrossRef Azizi G, Keller JM, Mayo ML, Piper K, Puett D, Earp KM, Malchoff CD (2016) Shear wave elastography and cervical lymph nodes: predicting malignancy. Ultrasound Med Biol 42(6):1273–1281CrossRef
7.
go back to reference Chen BB, Li J, Guan Y, Xiao WW, Zhao C, Lu TX, Han F (2018) The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: a preliminary study. Eur J Radiol 103:19–24CrossRef Chen BB, Li J, Guan Y, Xiao WW, Zhao C, Lu TX, Han F (2018) The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: a preliminary study. Eur J Radiol 103:19–24CrossRef
8.
go back to reference Ting CE, Yeong CH, Ng KH, Abdulla BJJ, Ting HE (2015) Accuracy of tissue elasticity measurement using shear wave ultrasound elastography: a comparative phantom study. In: World congress on medical physics and biomedical engineering. Springer, Toronto, pp 252–255 Ting CE, Yeong CH, Ng KH, Abdulla BJJ, Ting HE (2015) Accuracy of tissue elasticity measurement using shear wave ultrasound elastography: a comparative phantom study. In: World congress on medical physics and biomedical engineering. Springer, Toronto, pp 252–255
9.
go back to reference Menezes GLG, Pijnappel RM, Meeuwis C, Bisschops R, Veltman J, Lavin PT, van de Vijver MJ, Mann RM (2018) Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging. Radiology 17:170500 Menezes GLG, Pijnappel RM, Meeuwis C, Bisschops R, Veltman J, Lavin PT, van de Vijver MJ, Mann RM (2018) Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging. Radiology 17:170500
10.
go back to reference Lin L, Hu P, Shi J, Appleton CM, Maslov K, Li L, Zhang R, Wang LV (2018) Single-breath-hold photoacoustic computed tomography of the breast. Nat Commun 9(1):2352CrossRef Lin L, Hu P, Shi J, Appleton CM, Maslov K, Li L, Zhang R, Wang LV (2018) Single-breath-hold photoacoustic computed tomography of the breast. Nat Commun 9(1):2352CrossRef
11.
go back to reference Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV (2015) Dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection in patients with breast cancer. Sci Rep 5:15748CrossRef Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV (2015) Dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection in patients with breast cancer. Sci Rep 5:15748CrossRef
12.
go back to reference Forbrich A, Heinmiller A, Zemp RJ (2017) Photoacoustic imaging of lymphatic pumping. J Biomed Opt 22(10):106003CrossRef Forbrich A, Heinmiller A, Zemp RJ (2017) Photoacoustic imaging of lymphatic pumping. J Biomed Opt 22(10):106003CrossRef
13.
go back to reference Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J (2015) Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 7(317):317ra199CrossRef Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J (2015) Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 7(317):317ra199CrossRef
14.
go back to reference Luke GP, Myers JN, Emelianov SY, Sokolov KV (2014) Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors. Cancer Res 74(19):5397–5408CrossRef Luke GP, Myers JN, Emelianov SY, Sokolov KV (2014) Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors. Cancer Res 74(19):5397–5408CrossRef
15.
go back to reference Yang L, Cheng J, Chen Y, Yu S, Liu F, Sun Y, Chen Y, Ran H (2017) Phase-transition nanodroplets for real-time photoacoustic/ultrasound dual-modality imaging and photothermal therapy of sentinel lymph node in breast cancer. Sci Rep 7:45213CrossRef Yang L, Cheng J, Chen Y, Yu S, Liu F, Sun Y, Chen Y, Ran H (2017) Phase-transition nanodroplets for real-time photoacoustic/ultrasound dual-modality imaging and photothermal therapy of sentinel lymph node in breast cancer. Sci Rep 7:45213CrossRef
16.
go back to reference Kruger RA, Miller KD, Reynolds HE, Kiser WL, Reinecke DR, Kruger GA (2000) Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz—feasibility study. Radiology 216(1):279–283CrossRef Kruger RA, Miller KD, Reynolds HE, Kiser WL, Reinecke DR, Kruger GA (2000) Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz—feasibility study. Radiology 216(1):279–283CrossRef
17.
go back to reference Razansky D, Kellnberger S, Ntziachristos V (2010) Near-field radiofrequency thermoacoustic tomography with impulse excitation. Med Phys 37(9):4602–4607CrossRef Razansky D, Kellnberger S, Ntziachristos V (2010) Near-field radiofrequency thermoacoustic tomography with impulse excitation. Med Phys 37(9):4602–4607CrossRef
18.
go back to reference Lou C, Yang S, Ji Z, Chen Q, Xing D (2012) Ultrashort microwave-induced thermoacoustic imaging: a breakthrough in excitation efficiency and spatial resolution. Phys Rev Lett 109:218101 Lou C, Yang S, Ji Z, Chen Q, Xing D (2012) Ultrashort microwave-induced thermoacoustic imaging: a breakthrough in excitation efficiency and spatial resolution. Phys Rev Lett 109:218101
19.
go back to reference Ye F, Ji Z, Ding W, Lou C, Yang S, Xing D (2016) Ultrashort microwave-pumped real-time thermoacoustic breast tumor imaging system. IEEE Trans Med Imaging 35(3):839–844CrossRef Ye F, Ji Z, Ding W, Lou C, Yang S, Xing D (2016) Ultrashort microwave-pumped real-time thermoacoustic breast tumor imaging system. IEEE Trans Med Imaging 35(3):839–844CrossRef
20.
go back to reference Wen L, Yang S, Zhong J, Zhou Q, Xing D (2017) Thermoacoustic imaging and therapy guidance based on ultra short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles. Theranostics 7(7):1976–1989CrossRef Wen L, Yang S, Zhong J, Zhou Q, Xing D (2017) Thermoacoustic imaging and therapy guidance based on ultra short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles. Theranostics 7(7):1976–1989CrossRef
Metadata
Title
Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves
Authors
Russell S. Witte
Chandra Karunakaran
Andres N. Zuniga
Hannah Schmitz
Hina Arif
Publication date
01-08-2018
Publisher
Springer Netherlands
Published in
Clinical & Experimental Metastasis / Issue 5-6/2018
Print ISSN: 0262-0898
Electronic ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-018-9923-9

Other articles of this Issue 5-6/2018

Clinical & Experimental Metastasis 5-6/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine